Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-α production

Braña, Miguel F.; Acero, Nuria; Añorbe, Loreto; Mingarro, Dolores Muñoz; Llinares, Fernando Miró; Domı́nguez, Gema

doi:10.1016/j.ejmech.2009.03.018

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…[ 19 – 21 ] TNF-α is another main cytokine secreted by Th22 cells, which has been proved to be overproduced in several malignancies. [ 22 – 24 ] Moreover, its tumor-promoting effect has been clearly proved in mouse cancer models. [ 24 , 25 ] However, the role of Th22 cells is not clear in human cancer.…”

Section: Introductionmentioning

confidence: 99%

Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

et al. 2017

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“…Compounds 7a–7v were evaluated for their anti‐IFV activity in vitro and monitored by the MTS assay in the MDCK cells (27,28). The reference drugs of oseltamivir carboxylate, ribavirin, amantadine, and rimantadine were used for positive control.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Preliminary Biologic Evaluation of 5‐Substituted‐2‐(4‐substituted phenyl)‐1,3‐Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors

Zhan

Naesens

et al. 2012

Chem Biol Drug Des

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The diversity-oriented chemistry synthesis together with the random screening approach has permitted the discovery and optimization of novel antiviral lead compounds. In this paper, a series of novel 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles was synthesized and evaluated for their in vitro anti-influenza A virus and anti-influenza B virus activity. The activity was monitored by the MTS assay in the Madin-Darby canine kidney cells. Compound 7h showed excellent inhibitory activity and selective index against A ⁄ H3N2 (EC 50 = 37.03 lM, SI > 5), which were all higher than that of the reference drug oseltamivir (EC 50 > 59.00 lM, SI > 1). However, no compound displays inhibitory activity against influenza B virus.

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“…HL-60 cells do not produce detectable amounts of TNF-a under normal cell culture conditions but do begin to produce it in response to OA or TPA. 30 Therefore, these chemical inductors of TNF-a synthesis were used. Thalidomide was used as a positive control, and cells treated with PBS (negative control) produced no detectable amount of TNF-a.…”

Section: Acero and Muñ Oz-mingarromentioning

confidence: 99%

Effect on Tumor Necrosis Factor-α Production and Antioxidant Ability of Black Alder, as Factors Related to Its Anti-Inflammatory Properties

Acero

Muñoz‐Mingarro²

2012

Journal of Medicinal Food

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Alders exhibit several uses in different areas and also offer some nutritional and medicinal values. The bark and leaves from black alder [Alnus glutinosa (L.) Gaertn] are used in folk medicine for the treatment of inflammatory processes and other health disorders. This study assessed if an extract of A. glutinosa stem bark exhibits some biological properties linked to improving the inflammatory state, which could partly justify its ethnopharmacological use. Therefore, various aspects of antioxidant activity as well as the effect on tumor necrosis factor-α (TNF-α) production were evaluated. The phytochemical study revealed the presence of terpenes, saponins, tannins, flavonoids, and anthraquinones (by high-performance thin-layer chromatography). The betulinic acid content in the extract, determined by reversed-phase high-performance liquid chromatography (validated method), was 0.72±0.027%. In addition, high amounts for total phenols as well as flavonoids were determined. The extract exhibited a 2,2'-diphenylpicrylhydrazyl radical scavenging capacity similar to that of ascorbic acid and had a significant effect on superoxide anion scavenging, superior to that of ascorbic acid. It was also able to protect HeLa cells from induced oxidative stress. In the TNF-α assay, levels of this citokine were depressed by the extract in HL-60 cells. To test the effect of the extract on cell proliferation, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed. According to the results, the antioxidant properties displayed by the extract of A. glutinosa stem bark, together with the effect on TNF-α levels, suggest that these activities, linked to a successful reduction in inflammatory processes, may support, in part, its ethnopharmacological use.

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Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-α production

Cited by 14 publications

References 30 publications

Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

Synthesis and Preliminary Biologic Evaluation of 5‐Substituted‐2‐(4‐substituted phenyl)‐1,3‐Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors

Effect on Tumor Necrosis Factor-α Production and Antioxidant Ability of Black Alder, as Factors Related to Its Anti-Inflammatory Properties

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