Effect on Tumor Necrosis Factor-α Production and Antioxidant Ability of Black Alder, as Factors Related to Its Anti-Inflammatory Properties

Acero, Nuria; Muñoz‐Mingarro, Dolores

doi:10.1089/jmf.2011.0281

Cited by 11 publications

(10 citation statements)

References 24 publications

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“…Thus, Vit C and phenolic compounds in the product are possibly some of many active antioxidant compounds that could reduce lipid peroxidation, as seen in previous evidence. 82 The results of reducing TNF-∝ in the supplement group could be explained by Vit C activity on the depression and expression of transcription factor NF-Kappa B, 83 the same as for total phenolic compound. 84 Unfortunately, the activity on antioxidants and anti-inflammation among the COPD participants could not confirm Vit C or total phenolic compound as being in the product, as in a previous report on sweet-type star fruit extract.…”

Section: Discussionmentioning

confidence: 90%

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Pothasak¹,

Leelarungrayub²,

Natakankitkul³

et al. 2020

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Background: Star fruit (Averrhoa carambola L.) is a seasonal fruit, which has proven antioxidant and inflammation activities in vitro. However, sweet-type is more available than sour-type. Therefore, developing a new product from sweet-type star fruit, and evaluating its effectiveness on antioxidants and inflammation have been very challenging. Objectives: The aims were to develop a prototype product from sweet-type star fruit and evaluate its effectiveness with or without walking exercise on participants with stable chronic obstructive pulmonary disease (COPD). Methods: The prototype product of sweet-type star fruit was prepared industrially by mixing with honey before nutrients such as L-ascorbic acid (Vit C) and total phenolic compound, and contaminants like chemicals, microbials and oxalic acid were evaluated. Effectiveness of this product on antioxidents, inflammation and physical function was evaluated in participants with stable COPD with and without walking exercise, and compared to walking exercise and control participants. Two spoons of the product (20 g) in sterile warm water (150 mL) were guided and consumed twice daily for 4 weeks, whereas the walking exercise was prescribed with moderate intensity at home for 30 min 3 days per week. Plasma Vit C, total antioxidant capacity (TAC), malondialdehyde (MDA), tumor necrotic factoralpha (TNF-∝) and 6-minutes walking distance (6MWD) were evaluated before and after the 4-week study period. Results: The prototype product composed of star fruit juice with honey (1:1, v:v). Main nutrients were composed of ash (0.4 g), carbohydrate (74.59 g), lipid (2.88 g), protein (0.57 g) and 326.56 kcal of total energy, whereas Vit C and total phenolic compound were equivalent to 0.25 ± 0.11 mg and 144.89 ± 2.51 µg gallic acid equivalent in a 100 gram of product. The results of chemicals and microbials showed safety under food conditions. The results of study compared the ages of stable COPD participants between those of the controls (n=10, 69.20±1.40 years), and those with star fruit juice and honey supplement (n=20, 71.25 ± 6.01 years), walking exercise (n=15, 60.60±3.38 years), and supplement with walking exercise (n=15, 64.40±1.63 years) and no statistical difference was shown in any parameters in the control group. Whereas, the plasma Vit C and TAC levels increased, and MDA and TNF-∝ levels reduced significantly, in the supplement consumption group, which was in contrast to the Vit C, MDA and TNF-∝ levels in the walking exercise group. However, the TAC level increased significantly when the walking exercise was completed. When the prototype product was applied to the walking exercise, the levels of Vit C and TAC increased, and MDA and TNF-∝ levels reduced significantly. Whereas, the supplement levels increased significantly in all of the groups, especially in the 6MWD. Conclusion: This study proposed that sweet-type star fruit can be prepared industrially by mixing with honey, and be developed as a new commercial product with antioxidant and inflammation activities for p...

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Section: Discussionmentioning

confidence: 90%

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Pothasak¹,

Leelarungrayub²,

Natakankitkul³

et al. 2020

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“…This assay consists of analyzing the capacity of the verbascoside to reduce the stable radical DPPH• by donating a hydrogen, thereby forming DPPH-H. This reduction results in a color change in the DPPH, which goes from purple (oxidized form) (absorption band 517 nm) to yellow (reduced form) [27]. In a 96-well plate, 100 µL of DPPH 1 mM in MetOH and 100 µL of verbascoside or ascorbic acid were mixed at various concentrations in MetOH.…”

Section: Dpph• Scavenging Assaymentioning

confidence: 99%

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

Burgos,

Muñoz-Mingarro,

Navarro

et al. 2020

Antioxidants

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The phenomenon of today’s ageing population has increased interest in the search for new active substances that delay the onset and development of neurodegenerative diseases. In this respect, the search for natural compounds, mainly phenolic compounds, with neuroprotective activity has become the focus of growing interest. Verbascoside is a phenylethanoid that has already presented several pharmacological activities. The purpose of this study is to isolate and identify verbascoside from Acanthus mollis leaves. Consequently, its neuroprotective ability through enzymatic inhibition and free radical scavenging ability has been analyzed both in vitro and in cell culture assays. The antioxidant capacity of verbascoside was evaluated in vitro through total antioxidant capacity, DPPH•, OH•, and O2•—scavenging activity assays. The effect of verbascoside on intracellular reactive oxygen species (ROS) levels of HepG2 and SH-SY5Y cell lines was studied in normal culture and under induced oxidative stress. The inhibitory ability of the phenylethanoid against several enzymes implied in neurodegenerative diseases (tyrosinase, MAO-A, and AChE) was analyzed in vitro. Verbascoside neuroprotective activity is at least in part related to its free radical scavenging ability. The effect of verbascoside on ROS production suggests its potential in the prevention of harmful cell redox changes and in boosting neuroprotection.

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“…These results are in good agreement with another study by Stević et al ( 30 ), according to which the total phenolic content of other species of the Alnus genus, methanolic extract of A. incana and A. viridis , were 316.2±6.9 and 238.6±6.6 mg GAE/g, respectively. Futhermore, Acero and Muñoz-Mingarro ( 31 ) reported that the total flavonoid content of methanolic extract of A. glutinosa , another species of the Alnus genus, was 34.55±0.19 mg QE/g. Therefore, these results indicated that AFE, compared with the extracts of other Alnus species, contained high levels of flavonoids and phenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

Radical scavenging-linked anti-adipogenic activity of Alnus firma extracts

Choi

Lee

et al. 2017

Int J Mol Med

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The purpose of the present study was to investigate the antioxidant activity and anti-adipogenic effect of extracts from Alnus firma (A. firma), which is an edible plant that grows in mountainous areas. The total phenolic, flavonoid and anthocyanin content as well as the antioxidant activity of a 70% ethanolic extract of A. firma (AFE) was assessed. Furthermore, the effects of AFE on lipid accumulation and reactive oxygen species (ROS) production during adipogenesis of 3T3-L1 cells were investigated. The results revealed that the total phenolic, flavonoid and pro-anthocyanidin content of AFE as 436.26±3.30 mg gallic acid equivalents/g, 73.82±0.54 mg quercetin equivalents/g and 149.25±6.06 mg catechin equivalents/g, respectively. In addition, AFE exerted significant antioxidant effects in terms of 1,1-diphenyl-2-picryl hydrazyl radical scavenging activity, 2,2′-azino-bis(3-ethylbenzothia-zoline-6-sulfonic acid) radical scavenging activity, reducing power, oxygen radical absorbance capacity and nitric oxide radical scavenging activity. As for its anti-adipogenic activity, AFE significantly inhibited ROS production and lipid accumulation during adipogenesis of 3T3-L1 cells compared with those in control cells. In addition, AFE regulated adipogenic transcription factors including peroxisome proliferator-activated receptor-γ, CCAAT/enhance-binding protein α and adipocyte protein 2. These results indicated that A. firma is a potential candidate for a functional food supplement.

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Effect on Tumor Necrosis Factor-α Production and Antioxidant Ability of Black Alder, as Factors Related to Its Anti-Inflammatory Properties

Cited by 11 publications

References 24 publications

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

Radical scavenging-linked anti-adipogenic activity of Alnus firma extracts

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