Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

Wang, Ting; Zhang, Zhiwei; Xing, H. Rosie; Wang, Li; Zhang, Guoxiang; Yu, Na; Wang, Junzhi; Guo, Wei; Jiang, Jie

doi:10.1097/md.0000000000008359

Cited by 19 publications

(17 citation statements)

References 50 publications

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“…Correlations between prognosis and the frequency of CD8 + naïve and memory T cells and Treg have also been reported. Our data extend these findings by showing that naïve, memory, and regulatory T cell subsets that were previously associated with disease progression in people with cancer also correlate with independent predictors of cancer progression, specifically measures of muscle function.…”

Section: Discussionsupporting

confidence: 84%

“…Previously published results have shown changes in the frequency of several T cell subsets in people with cancer, including CD8 + and CD4 + T cells, Treg cells, and pro‐inflammatory Th17 and Th22 cells . Other studies have reported a reduction in B cells in people with cancer.…”

Section: Discussionmentioning

confidence: 95%

“…Over the past four decades, many studies have focused on identifying changes in the circulating T cell immune profile in people with cancer, compared with healthy controls. These studies have reported an elevated frequency of several cell subsets including CD8 + and CD4 + T cells, Treg cells, and pro‐inflammatory Th17 cells in people with cancer. Other studies have reported a reduction in B cells in people with cancer.…”

Section: Introductionmentioning

confidence: 99%

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Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Narsale

Moya

et al. 2019

J cachexia sarcopenia muscle

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Background Tumour growth can promote the loss of muscle mass and function. This is particularly disturbing because overall survival is significantly reduced in people with weaker and smaller skeletal muscle. The risk of cancer is also greater in people who are immune deficient. Muscle wasting in mice with cancer can be inhibited by infusion of CD4 + precursor T cells that restore balanced ratios of naïve, memory, and regulatory T cells. These data are consistent with the hypothesis that stronger anti‐cancer T cell immunity leads to improved muscle mass and function. As a first step to testing this hypothesis, we determined whether levels of circulating T cell subsets correlate with levels of muscle strength in people with cancer. Methods The frequency of circulating CD4 + and CD8 + naïve, memory, and regulatory T cell subsets was quantified in 11 men with gastrointestinal cancer (aged 59.3 ± 10.1 years) and nine men without cancer (aged 60 ± 13 years), using flow cytometry. T cell marker expression was determined using real‐time PCR and western blot analyses in whole blood and peripheral blood mononuclear cells. Handgrip strength, one‐repetition maximum chest press, and knee extension tests were used to determine muscle strength. Performance was determined using a stair climb test. Body composition was determined using dual‐energy X‐ray absorptiometry scan. The Karnofsky and ECOG scales were used to assess functional impairment. Correlations between frequencies of cell subsets with strength, performance, and body composition were determined using regression analyses. Results Our data show significant correlations between (i) higher frequencies of CD8 + naïve ( P = 0.02) and effector memory ( P = 0.003) T cells and lower frequencies of CD8 + central memory T cells ( P = 0.002) with stronger handgrip strength, (ii) lower frequency of regulatory cells with greater lean mass index ( P = 0.04), (iii) lower frequency of CD8 + T cells that express CD95 with greater stair climb power ( P = 0.003), (iv) higher frequency of T cells that co‐express CD197 and CD45RA and greater one‐repetition maximum knee extension strength ( P = 0.008), and (iv) higher expression of CD4 in whole blood with greater functional impairment ( P = 0.004) in people with cancer. Conclusions We have identified significant correlations between levels of T cell populations and muscle strength, performance, and body composition in people with cancer. These data justify a follow‐up study with a larger cohort to test the validity of the findings.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Narsale

Moya

et al. 2019

J cachexia sarcopenia muscle

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“…CAFs crosstalk with cancer cells through secretion of various cytokines and affect tumor proliferation, invasion, and metastasis. In mouse models, the pro-inflammatory signature generated by CAFs correlated with the pathogenesis of human breast, uterine, and ovarian cancers [10,16]. Additionally, secretion of collagen by CAFs was also enhanced compared to NFs [17].…”

Section: Introductionmentioning

confidence: 95%

“…Among the subsets of Th cells, Th22 is acknowledged as a distinct subset compared to the other Th cells [9]. Th22 cells are characterized by an abundant production of interleukin-22 (IL-22) and tumor necrosis factor-α (TNF-α), and a limited secretion of IL-4, IL-17A, and interferon-γ (IFN-γ) [10,11]. IL-22, the main cytokine released by Th22 cells, belongs to the IL-10 cytokine family [12].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-22 derived from cervical cancer-associated fibroblasts accelerates senescence of normal fibroblasts and promotes expression of tumorigenesis-related factors in HeLa cells

2020

EJGO

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The present study aimed to evaluate the effect of interleukin-22 (IL-22), secreted by cervical cancer-associated fibroblasts (CAFs), on the senescence of normal fibroblasts (NFs) and the malignant characteristics of cancer cells. CAFs and NFs were isolated from clinical tissue samples and the degrees of senescence were compared. NFs were cultured with a CAF-conditioned medium and analyzed for the expression of senescence markers. HeLa cells were cultured with an exogenous IL-22 supplement and analyzed for the expression of tumor markers. Compared to NFs, CAFs showed a delayed growth and an elevated activity of senescence-associated β-galactosidase (SA β-gal). Expression of α-SMA, p16, and IL-22 was upregulated in the CAFs. Further, the CAF-conditioned medium promoted the senescence of NFs through the suppression of cell proliferation and the elevated expression of α-SMA and p16; whereas the addition of an IL-22 antibody reversed the senescence process. Exogenous IL-22 upregulated N-cadherin and downregulated E-cadherin in HeLa cells. The IL-22 supplement also increased the expression of VEGF, MMP2, and MMP9 in HeLa cells. In conclusion, IL-22 produced by CAFs accelerated the senescence of NFs and promoted the expression of tumorigenesis-related factors in HeLa cells.

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Conventional T Cell Subsets and Their Roles Within the Tumor Microenvironment

Azimnasab-Sorkhabi,

Soltani-Asl,

Ansa-Addo

et al. 2024

Interdisciplinary Cancer Research

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Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 19 publications

References 50 publications

Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Interleukin-22 derived from cervical cancer-associated fibroblasts accelerates senescence of normal fibroblasts and promotes expression of tumorigenesis-related factors in HeLa cells

Conventional T Cell Subsets and Their Roles Within the Tumor Microenvironment

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