Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Kumar, K. Ravi; Nightingale, Adrian M.; Krishnadasan, Siva H.; Kamaly, Nazila; Wylenzinska-Arridge, Marzena; Zeissler, Katharina; Branford, W. R.; Ware, Ecaterina; deMello, Andrew J.; deMello, John C.

doi:10.1039/c2jm30257h

Cited by 115 publications

(94 citation statements)

References 37 publications

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“…Hence, in addition to removing weakly bound dextran more efficiently, SEC leads to a stronger coordination between remaining dextran molecules and the IONC surfaces. 49 It should also be emphasized that the peak at 1043 cm −1 becomes predominant compared to the one at 1020 cm −1 , which is not the case for D-IONCs or dextran alone. In the literature, the weak bands near 1040 and 1020 cm −1 have been correlated to the crystalline (more ordered) and amorphous (less ordered) phases of dextran, respectively.…”

Section: ■ Results and Discussionmentioning

confidence: 98%

Rapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry

et al. 2015

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Progresses in cold atmospheric plasma technologies have made possible the synthesis of nanoparticles in aqueous solutions using plasma electrochemistry principles. In this contribution, a reactor based on microhollow cathodes and operating at atmospheric pressure was developed to synthesize iron-based nanoclusters (nanoparticles). Argon plasma discharges are generated at the tip of the microhollow cathodes, which are placed near the surface of an aqueous solution containing iron salts (FeCl2 and FeCl3) and surfactants (biocompatible dextran). Upon reaction at the plasma-liquid interface, reduction processes occur and lead to the nucleation of ultrasmall iron-based nanoclusters (IONCs). The purified IONCs were investigated by XPS and FTIR, which confirmed that the nucleated clusters contain a highly hydrated form of iron oxide, close to the stoichiometric constituents of α-FeOOH (goethite) or Fe5O3(OH)9 (ferrihydrite). Relaxivity values of r1 = 0.40 mM(-1) s(-1) and r2/r1 = 1.35 were measured (at 1.41 T); these are intermediate values between the relaxometric properties of superparamagnetic iron oxide nanoparticles used in medicine (USPIO) and those of ferritin, an endogenous contrast agent. Plasma-synthesized IONCs were injected into the mouse model and provided positive vascular signal enhancement in T1-w. MRI for a period of 10-20 min. Indications of rapid and strong elimination through the urinary and gastrointestinal tracts were also found. This study is the first to report on the development of a compact reactor suitable for the synthesis of MRI iron-based contrast media solutions, on site and upon demand.

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Section: ■ Results and Discussionmentioning

confidence: 98%

Rapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry

et al. 2015

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“…The superparamagnetic character of the nanoparticles is confirmed by the absence of hysteresis in the magnetization curve. Similar strategy based on droplet microfluidics has been reported by Kumar et al [41] by using a driven capillary-based droplet reactor for the aqueous preparation of dextran-coated superparamagnetic iron oxide nanoparticles. The reactor yielded small, stable, highly crystalline particles with a narrow size distribution ( d /d = 22%), a large saturation magnetization of 58 emu g −1 , and a high T2 relaxivity of 66 mM −1 s −1 .…”

Section: Synthesis Of -Fe 2 O 3 Nanoparticles In Microfluidic Reactorsmentioning

confidence: 93%

Synthetic Formation of Iron Oxides

2016

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“…Later in 2012, Kumar et al [233] reported a simpler passive methodology for direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor where droplets are formed close to the end of a length of silicone tubing at the contact point between two auxiliary capillaries. Compared to Frenz et al method, [232] there was no need for the surface modification of the channel and high voltage power sources.…”

Section: Droplet-based Microreactorsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Cited by 115 publications

References 37 publications

Rapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry

Rapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry

Synthetic Formation of Iron Oxides

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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