Direct surface PEGylation of nanodiamond via RAFT polymerization

Shi, Yuying; Liu, Meiying; Wang, Ke; Huang, Hongye; Wan, Qing; Tao, Lei; Fu, Lihua; Zhang, Xiaoyong; Wei, Yen

doi:10.1016/j.apsusc.2015.09.200

Cited by 39 publications

(20 citation statements)

References 49 publications

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“…Surface-initiated living radical polymerization reactions provide a good alternative for the biomedical materials surface modification, as obtaining the well-defined polymer brushes. Reversible addition-fragmentation chain transfer (RAFT) polymerization is one of the living radical polymerization techniques and it has enjoyed widespread acceptance as a modification technique due to its capability to control polymerization of diverse monomers under mild reaction conditions without the requirement of metal catalysts [12][13][14]. Antifouling surface can be obtained via surfaceinitiated RAFT polymerization of antifouling molecules on the material surface [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Tang

Han

Chen

et al. 2016

International Journal of Polymer Science

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Poly(dimethylsiloxane) silicones have found many applications in biomedical devices, whereas their surface hydrophobicity always brings about unexpected bioadhesion, causing complications of the implanted biomedical devices. In this work, surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization was utilized to generate PEG brushes on silicone surface, obtaining highly hydrophilic surface coatings. Such PEG brush coated silicone presents excellent antifouling to protein, cells, and bacteria, which may have great potential in implantable biomaterial surface modifications.

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Section: Introductionmentioning

confidence: 99%

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Tang

Han

Chen

et al. 2016

International Journal of Polymer Science

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“…Polyethylene glycol (PEG) along with its methacrylate derivatives and hyperbranched polyglycerol (PG) are typical examples of polymers investigated to form hydrophilic shells on the surface of DNDs which have been successfully used to increase their stability in aqueous solution [26, 27]. …”

Section: Synthesis and Functionalization Of Ndsmentioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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“…Apart from carbodiimide chemistry, which has been applied for covalent conjugation with PLL, PEG, fructose polymers, and others, three different types of surface‐initiated polymerization methods have been established for surface modification of NDs and FNDs: (a) atom transfer radical polymerization, (b) reversible addition‐fragmentation chain transfer polymerization, and (c) ring‐opening polymerization . Specifically, Komatsu and coworkers developed a method of grafting hyperbranched polyglycerol (PG) on the ND surface via ring‐opening reactions of glycidol .…”

Section: Biohybrid Fndsmentioning

confidence: 99%

Biohybrid fluorescent nanodiamonds as dual‐contrast markers for light and electron microscopies

Sotoma

Hsieh

Chang

2018

J Chinese Chemical Soc

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Cathodoluminescence (CL) and correlative light‐electron microscopy (CLEM) are two useful analytical tools in diverse research areas. Recently, fluorescent nanodiamonds (FNDs) have emerged as promising imaging agents for both CL and CLEM owing to their exceptional photophysical and chemical properties. However, to realize their practical applications in the life sciences, surface modification and functionalization of the nanomaterials with bioactive molecules are critical and essential. Here we provide a comprehensive review on the methods of synthesizing biohybrid FNDs as well as recent advances of CL and CLEM imaging of cells with these carbon nanoparticles as dual‐contrast markers.

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Direct surface PEGylation of nanodiamond via RAFT polymerization

Cited by 39 publications

References 49 publications

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Biohybrid fluorescent nanodiamonds as dual‐contrast markers for light and electron microscopies

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