Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Tang, Junmei; Han, Yuemei; Chen, Hao; Lin, Quankui

doi:10.1155/2016/8458752

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…2 a). Our observations are in agreement with the previous studies regarding the typical stages of bio-fouling development that bioorganisms can multiply locally and then assemble to form microcolonies [ 14 , 15 ]. The obvious reduction in the number of algal cells adhered to PFDT modified silicon substrate (Fig.…”

Section: Resultssupporting

confidence: 93%

Surface thiolation of silicon for antifouling application

Zhang

Gao

Hollimon

et al. 2018

Chemistry Central Journal

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Thiol groups grafted silicon surface was prepared as previously described. 1H,1H,2H,2H-perfluorodecanethiol (PFDT) molecules were then immobilized on such a surface through disulfide bonds formation. To investigate the contribution of PFDT coating to antifouling, the adhesion behaviors of Botryococcus braunii (B. braunii) and Escherichia coli (E. coli) were studied through biofouling assays in the laboratory. The representative microscope images suggest reduced B. braunii and E. coli accumulation densities on PFDT integrated silicon substrate. However, the antifouling performance of PFDT integrated silicon substrate decreased over time. By incubating the aged substrate in 10 mM TCEP·HCl solution for 1 h, the fouled PFDT coating could be removed as the disulfide bonds were cleaved, resulting in reduced absorption of algal cells and exposure of non-fouled silicon substrate surface. Our results indicate that the thiol-terminated substrate can be potentially useful for restoring the fouled surface, as well as maximizing the effective usage of the substrate.Electronic supplementary materialThe online version of this article (10.1186/s13065-018-0385-6) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 93%

Surface thiolation of silicon for antifouling application

Zhang

Gao

Hollimon

et al. 2018

Chemistry Central Journal

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“…[3][4][5][6]39 Cell-resistant surface can be generated via hydrophilic macromolecule immobilization or hydrogel-like surface coating. [40][41][42][43][44][45] In this study, we fabricated the zwitterionic PMPC brush onto the hydrophobic IOL surface via SI-RAFT polymerization. Such zwitterionic PMPC brush modification can effectively reduce the initial adhesion of residual LECs or bacteria, and is prospective in reducing the PCO incidence in vivo.…”

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confidence: 99%

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Han¹,

Xu²,

Tang³

et al. 2016

IJN

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“…However, recent clinical research has demonstrated that there is no significant difference in PCO incidences between the patients who were treated by the HEP-modified IOLs or the pristine IOLs implantation 12. In our previous animal investigations, the surface hydrophilic or superhydrophilic modifications had some positive effects on the PCO prevention in short time observations 13–17,28. However, if the postoperative observation time duration prolonged, the PCO also started to develop in the hydrophilic-modified IOLs 14–16.…”

Section: Resultsmentioning

confidence: 88%

<p>Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification</p>

Han

Tang

Xia

et al. 2019

IJN

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BackgroundPosterior capsular opacification (PCO) is the main complication after intraocular lens (IOL) implantation in cataract surgery, which is the result of lens epithelial cell (LEC) adhesion, proliferation and migration on the IOL and at the lens capsule interface. Hydrophilic surface modification, such as surface heparinization, decreases the cell adhesion, which has been commercialized and used clinically. However, clinical long-term observation results show no significant difference between the pristine and heparinized IOLs.MethodsTo prevent PCO over the long time span, we modified the IOLs with an antiproliferative drug-loaded hydrophilic coating. The antiproliferative drug doxorubicin (DOX)-incorporated chitosan (CHI) nanoparticle was fabricated by sodium tripolyphosphate (TPP) gelation. Such antiproliferative drug-loaded CHI-TPP-DOX nanoparticles (CTDNP) were used as one of the building blocks to prepare polyelectrolyte multilayer with heparin (HEP) via layer-by-layer assembly, obtaining (HEP/CTDNP)n multilayers. The assembly process was characterized by quartz crystal microbalance with dissipation (QCM-D). The drug release behavior of the coating was investigated by ultra-HPLC (UPLC). In vitro cell experiments were carried out to monitor the effects of multifunctional coatings on cellular adhesion, proliferation and migration. And the intraocular implantation was performed on rabbits to evaluate the in vivo PCO inhibitory effect of such surface-functionalized IOLs.ResultsThe positively charged CTDNP was successfully prepared by ionic gelation. The QCM-D results indicate the successful preparation of the (HEP/CTDNP)n multilayer film. Drug release profiles showed that surface-multifunctionalized IOL had drug-sustained release properties. In vitro cell culture results showed significant inhibition of adhesion, proliferation and migration of LECs after surface modification. The in vivo results showed that the IOLs with multifunctionalized surface can effectively reduce the posterior hyperplasia and Soemmering’s ring (SR) formation.ConclusionThese findings suggested that such multifunctionalized drug-eluting IOLs can effectively reduce the posterior hyperplasia and SR formation when intraocular implantation has a major impact on reducing PCO incidence. Thus they have a great potential in improving patient vision recovery and maintenance.

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Bottom-Up Fabrication of PEG Brush on Poly(dimethylsiloxane) for Antifouling Surface Construction

Cited by 13 publications

References 20 publications

Surface thiolation of silicon for antifouling application

Surface thiolation of silicon for antifouling application

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

<p>Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification</p>

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