Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Han, Yuemei; Xu, Xu; Tang, Junmei; Shen, C. S.; Lin, Quankui; Chen, Hao

doi:10.2147/ijn.s107491

Cited by 32 publications

(30 citation statements)

References 42 publications

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“…The corneal tissue from rabbits treated with dendrimer had a clear organizational structure ( Fig. 7 A and B) (29). Similar results were found in the retinal tissues ( Fig.…”

Section: In Vivo Biocompatibility Evaluationsupporting

confidence: 82%

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Chen

Tang

Wen

et al. 2020

Preprint

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Backgrounds: The human eye is a sophisticated and sensitive sensory organ. Due to its dynamic and static barriers, efficient drug therapy for eye diseases is problematic. Polymeric delivery systems have been rapidly developed to overcome this problem, where polymeric dendrimers have received much attention for their unique structures. However, there is insufficient research on whether dendrimer nanomaterials could be used in ophthalmology. Poly (amidoamine) (PAMAM) is a kind of commercialized and extensively used dendrimer. Herein the ocular cytotoxicity and biosafety of PAMAM dendrimers were deeply evaluated by conducting in vitro and in vivo experiments on ocular systems. The effects of generation (G4.0, G5.0, and G6.0) and concentration on cell metabolism, apoptosis, and oxidative damage were carried out. Ocular irritation and intravitreal injection effects were also measured. Results: The results showed that the cytotoxicity of PAMAM increased with increasing generation number. PAMAM at a concentration that below 50 μg/mL was less harmful to the ocular tissues, whereas it caused apparent damage when above 50 μg/mL in the investigated situation. Moreover, singlet oxygen generation was detected in the cells after 50 μg/mL (and above) PAMAM treatment. The in vivo results show that there is no macroscopic structural change observed from fundus and histopathological section images, whereas it shows more functional impairment according to optical coherence tomography (OCT) and electroretinogram (ERG) when treated by 100 μg/mL PAMAM. Conclusion: Overall, a higher concentration of PAMAM, such as above 50 μg/mL, may cause ocular functional damage. The concentrations that are (or lower than) 50 μg/mL showed good biocompatibility and biosafety in human ocular cells and tissues.

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“…The corneal tissue from rabbits treated with dendrimer had a clear organizational structure ( Fig. 7 A and B) (29). Similar results were found in the retinal tissues ( Fig.…”

Section: In Vivo Biocompatibility Evaluationsupporting

confidence: 82%

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Chen

Tang

Wen

et al. 2020

Preprint

Self Cite

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“…In Han et al [121] study they incorporated quaternary ammonium methacrylates in dental adhesives to prevent caries by avoiding the accumulation of bacteria and biofilm formation on teeth, testing the presence of three Staphyloccocal species (Staphylococcus mutans, Staphylococcus gordonii, and Staphylococcus sanguinis) and the results showed a decreased biofilm formation for the adhesives containing the quaternary ammonium methacrylates.…”

Section: Loading Antimicrobial Compounds Into Materialsmentioning

confidence: 99%

Self-disinfecting surfaces and infection control

Querido

Aguiar

Neves

et al. 2019

Colloids and Surfaces B: Biointerfaces

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“…For this purpose, diverse surface modification strategies have been adopted using the surgical IOL system. [ 8–13 ] Various antiadhesive surface coatings have been tested using water‐soluble and hydrophilic polymers, such as ethylene glycol, 2‐(hydroxyethyl)methacrylate (HEMA), phospholipid‐containing monomer (2‐methacryloyloxyethyl phosphorylchlorine, MPC), and hyaluronic acid. [ 3,11,14,15 ] The antibacterial surfaces such as an antibiotic‐releasing coating, [ 10,13,16 ] coatings based on peptides, and quaternary ammonium compounds have been implemented.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Nanopillar Array for an Implantable Intraocular Lens

Choi

Song

Lim

et al. 2020

Adv Healthcare Materials

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Postsurgical intraocular lens (IOL) infection caused by pathogenic bacteria can result in blindness and often requires a secondary operation to replace the contaminated lens. The incorporation of an antibacterial property onto the IOL surface can prevent bacterial infection and postoperative endophthalmitis. This study describes a polymeric nanopillar array (NPA) integrated onto an IOL, which captures and eradicates the bacteria by rupturing the bacterial membrane. This is accomplished by changing the behavior of the elastic nanopillars using bending, restoration, and antibacterial surface modification. The combination of the polymer coating and NPA dimensions can decrease the adhesivity of corneal endothelial cells and posterior capsule opacification without causing cytotoxicity. An ionic antibacterial polymer layer is introduced onto an NPA using an initiated chemical vapor deposition process. This improves bacterial membrane rupture efficiency by increasing the interactions between the bacteria and nanopillars and damages the bacterial membrane using quaternary ammonium compounds. The newly developed ionic polymer‐coated NPA exceeds 99% antibacterial efficiency against Staphylococcus aureus, which is achieved through topological and physicochemical surface modification. Thus, this paper provides a novel, efficient strategy to prevent postoperative complications related to bacteria contamination of IOL after cataract surgery.

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Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Cited by 32 publications

References 42 publications

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Are PAMAM dendrimers safe for ocular applications? -- Toxicological evaluation in ocular cells and intraocular tissues

Self-disinfecting surfaces and infection control

Antibacterial Nanopillar Array for an Implantable Intraocular Lens

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