Direct Resolution of Enantiomers in Column Liquid Chromatography

Audebert, R.

doi:10.1080/01483917908060125

Cited by 64 publications

(3 citation statements)

References 81 publications

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“…Its separation is based on a physico-chemical phenomenon whereby a compound in a mobile phase known as the eluent, liquid or gaseous phase, is adsorbed onto the surface of a solid phase, usually a porous adsorbent. Chromatography displays some advantages over crystallization and membrane separations once it may be applied for a mixture of more than two chiral compounds and it can run with samples of small amount for analytical purposes [84]. Its separation is based on the chemical affinity of each compound to a stationary phase.…”

Section: Chromatographymentioning

confidence: 99%

Enantiomers and Their Resolution

2022

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Enantiomers share the same chemical formula but have different chemical structures, i.e., type of isomers. Enantiomers are present in several drugs, perfumes, food, and are a fundamental part of biomolecules. This subject is highly important for pharmaceutical companies. Enantiomeric drugs present different actuation in the human body; depending on the compound, one might combat the symptom, whereas its pair might cause damage. The separation of pairs of enantiomers requires a chiral environment that provokes a structural imbalance that conventional methods cannot provide. Enantioresolution is one of the most promissory studies that benefit several areas, such as pharmaceutical, biotechnology, food industry, and fine chemistry. Its resolution is of great importance, therefore, its main mechanisms of resolution will be explained herein.

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Section: Chromatographymentioning

confidence: 99%

Enantiomers and Their Resolution

2022

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“…The present disadvant 88 styrene are its lower pressure tolerance, I c its tendency to swell in organic solvents, l and also the fact that lower column effi-0 ciencies are observed in comparison to silica-based packings. Considerable progress is being made in developing systems for separating enantiomers by HPLC (20). Of particular note is the work of Pirkle et al (21,22) on the rational design of chiral stationary phases.…”

Section: Gas Chromatographymentioning

confidence: 99%

Trends in Analytical Scale Separations

Jorgenson

1984

Science

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Although gas chromatography has been called a mature technology, advances are still being made in the development of faster columns as well as detectors which yield more information on solutes. In liquid chromatography short columns packed with 3-micrometer particles are already popular for fast analyses, while long narrow-bore columns are being developed for high-resolution separations. An increasing range of detection modes is enhancing the problem-solving capabilities of liquid chromatography. Electrophoresis continues to be of central importance to molecular biology. Computer-aided analysis and display of electropherogram patterns is helping researchers to better comprehend the wealth of data from two-dimensional electrophoresis. A new mode of two-dimensional electrophoresis is permitting separation of whole chromosomes containing as many as 3 million base pairs.

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“…Nonionic chiral stationary phases that bind dissolved molecules by charge transfer (316,364) were used to separate dZ-sulfoxides (387) and helicenes (338). Resolution of optical isomers and chiral recognition of ionic and nonionic species is discussed by Audebert in a comprehensive review (16).…”

mentioning

confidence: 99%

Ion exchange and liquid column chromatography

Walton¹

1980

Anal. Chem.

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Direct Resolution of Enantiomers in Column Liquid Chromatography

Cited by 64 publications

References 81 publications

Enantiomers and Their Resolution

Enantiomers and Their Resolution

Trends in Analytical Scale Separations

Ion exchange and liquid column chromatography

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