Direct Renal Vasodilatation Produced by Dopamine in the Dog

McNay, J. L.; McDonald, Robert H.; Goldberg, Leon I.; Davis, Corrine R.

doi:10.1161/01.res.16.6.510

Cited by 226 publications

(69 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However the effects of DA on renal blood flow may be reduced by α receptor activation at higher dose [23]. On the other hand, changes in renal blood flow with DB, AM and ML were small [13,28].…”

Section: Discussionmentioning

confidence: 89%

Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

Tobata

Takao

Mochizuki

et al. 2004

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs. Dopamine increased blood flow in ventricular myocardium. Furthermore dopamine induced the increase in blood flow in intestine and kidney at low to middle dose, but not at high dose. Dobutamine induced the highest increase in blood flow in ventricular myocardium and skeletal muscle among the drugs evaluated at middle and high doses. Amrinone and milrinone increased blood flow in ventricular myocardium almost same with catecholamines, and milrinone decreased vascular resistance moderately in most other organs. Milrinone might be more useful than catecholamines for improvement of congestive heart failure or peripheral circulatory failure accompanied with exceeded vasoconstriction.

show abstract

Section: Discussionmentioning

confidence: 89%

Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

Tobata

Takao

Mochizuki

et al. 2004

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…The popularity of dopamine has, as its basis, several studies1-5 showing that dopamine is less chronotropic and has less dramatic peripheral vascular effects than the other catecholamines. In addition, dopamine appears to have a unique property of stimulating renovascular receptors (dopaminergic receptors) directly.3 [6][7][8][9][10] Tuttle and Mills" have systematically formulated and synthesized a new catecholamine, dobutamine, designed to selectively increase cardiac contractility without altering heart rate and blood pressure.…”

mentioning

confidence: 99%

Comparative systemic and regional hemodynamic effects of dopamine and dobutamine in patients with cardiomyopathic heart failure.

Leier¹,

Heban²,

Huss³

et al. 1978

Circulation

414

View full text Add to dashboard Cite

SUMMARY Thirteen patients with severe cardiac failure underwent a single crossover study of dopamine and dobutamine in order to compare the systemic and regional hemodynamic effects of the two drugs. The dose-response data demonstrated that dobutamine (2.5-10 ,ug/kg/min) progressively and predictably increases cardiac output by increasing stroke volume, while simultaneously decreasing systemic and pulmonary vascular resistance and pulmonary capillary wedge pressure. There was no change in heart rate or premature ventricular contractions (PVCs)/min at this dose range. Dopamine (2-8 ,ug/kg/min) increased the stroke volume and cardiac output at 4 ,g/kg/min. Dopamine at >4 ,Ag/kg/min provided little additional increase in cardiac output and increased the pulmonary wedge pressure and the number of PVCs/min. At >6 Ag/kg/min, dopamine increased heart rate. During the 24-hour maintenance-dose infusion of each drug (dopamine 3.7-4, dobutamine 7.3-7.7 ,ug/kg/min), only dobutamine maintained a significant increase of stroke volume, cardiac output, urine flow, urine sodium concentration, creatinine clearance and peripheral blood flow. Renal and hepatic blood flow were not significantly altered by the maintenance dose of either drug. Systemic and regional hemodynamic data suggest that dobutamine has many advantages over dopamine when infused in patients with cardiac failure. DOPAMINE HAS REPLACED most other catecholamine preparations (e.g., isoproterenol, norepinephrine) in clinical situations where inotropic and circulatory support is required. The popularity of dopamine has, as its basis, several studies1-5 showing that dopamine is less chronotropic and has less dramatic peripheral vascular effects than the other catecholamines. In addition, dopamine appears to have a unique property of stimulating renovascular receptors (dopaminergic receptors) directly.3 6-10 Tuttle and Mills" have systematically formulated and synthesized a new catecholamine, dobutamine, designed to selectively increase cardiac contractility without altering heart rate and blood pressure.Animal and human data'2-18 indicate that dobutamine increases stroke volume, cardiac output and overall cardiocirculatory performance in a dose range that does not elicit significant chronotropic and peripheral vascular responses. Dobutamine has also improved some parameters of renal function in patients with severe cardiac failure."8 Acute hemodynamic studies (catheterization laboratory data) comparing dopamine and dobutamine19 20 suggest that the ventricular function of patients with heart failure improves with both agents; however, dobutamine appears to be less chronotropic and, in contrast to dopamine, tends to lower left ventricular filling pressure. This study was designed to compare the dose-hemodynamic response curves, the maintenance dose-systemic and regional responses (during a 24-hour infusion) and the withdrawal responses of dopamine and dobutamine in 13 patients with low output cardiac failure. Methods and Materials PatientsThirteen patients with modera...

show abstract

“…However, pharmacologically, low dose dopamine does have renal vasodilator effect. [12] Dopamine increases excretion of sodium in urine. Therefore, theoretically, low dose dopamine promotes renal blood flow increasing the glomerular filtration rate and urine output.…”

Section: Discussionmentioning

confidence: 99%