Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

Tobata, Denji; Takao, Kenji; Mochizuki, Manabu; Nishimura, Ryohei; Sasaki, Nobuo

doi:10.1292/jvms.66.1097

Cited by 23 publications

(18 citation statements)

References 30 publications

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“…This is relevant because higher doses of dopamine must be used to generate higher blood pressures and dose-dependent effects of dopamine on regional perfusion exist. Specifically, dopamine increases gastric blood flow in dogs at moderate doses but decreases blood flow to the stomach at higher doses [12].…”

Section: Norepinephrinementioning

confidence: 96%

Vasoactive drugs and the gut: is there anything new?

Woolsey

Coopersmith

2006

Current Opinion in Critical Care

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Purpose of reviewSystemic changes in blood pressure and cardiac output induced by pressors and inotropes do not always correlate to improvements in regional perfusion. Since the gut is often referred to as the 'motor' of the systemic inflammatory response syndrome, the impact of vasoactive agents on splanchnic perfusion has theoretical importance. This review will highlight recent studies examining secondary effects of vasoactive agents on intestinal perfusion, metabolism, and barrier function. Recent findingsNorepinephrine has minimal impact on mesenteric blood flow although the combination of norepinephrine and dobutamine increases splanchnic blood flow in sepsis. Dopamine also increases mesenteric blood flow although this may be associated with negative hepatic energy balance at high does. Vasopressin and epinephrine both have negative effects on splanchnic blood flow. Newer inodilators levosimendan and olprinone preferentially improve mesenteric perfusion in animal models. Summary Secondary effects of norepinephrine and dopamine on splanchnic perfusion are minor compared with their systemic effects. While vasopressin usage is increasing in the intensive care unit, caution should be used because of its adverse effects on gut perfusion. Experimental agents for the treatment of heart failure have beneficial gut-specific effects although the clinical significance of this is currently limited by their availability.

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Section: Norepinephrinementioning

confidence: 96%

Vasoactive drugs and the gut: is there anything new?

Woolsey

Coopersmith

2006

Current Opinion in Critical Care

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“…[10] In their study on healthy dogs with different inotropic agents, Tobato et al found that the renal blood flow was altered with the use of amrinone and milrinone, though these alterations were not statistically significant. [11] However, all members of the type III PDE inhibitors have similar clinical effects, as the former three drugs, being biypridine derivatives, are chemically diverse from enoximone, an imidazole derivative. This chemical diversity can be speculated as the reason for different effects on the renal tissue.…”

Section: Discussionmentioning

confidence: 99%

Apart from the Other Members of PDE Inhibitors' Family, Enoximone Does Not Enhance Renal Ischemic Reperfusion Injury: The Effects of Enoximone on Renal Ischemia Reperfusion

et al. 2009

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Many pharmacological agents were investigated for the prevention of renal ischemic reperfusion (IR) injury as well as the phosphodiesterase (PDE) inhibitors. The aim of the study was to examine the possible renoprotective effect of enoximone as a member of this family on IR injury. Thirty-six Wistar-Albino rats were allocated to six groups. Sham (S) and control groups (E1, E2) only received 0.09% NaCl, 5 mg/kg and 10 mg/kg enoximone via caudal caval vein, respectively. In ischemia (I) and treatment groups (IE1, IE2), the rats were subjected to bilateral renal artery occlusion and were given 0.09% NaCl, 5 mg/kg and 10 mg/kg enoximone in the same route, respectively. Bilateral kidneys were removed at the sixth hour of laparotomy for histopathological and biochemical analysis, such as superoxide dismutase, myeloperoxidase, malonyldialdehyde, and nitric oxide end products. Blood samples were taken in order to evaluate renal function tests. The data were analyzed by using one-way analysis of variance, and p < .05 was considered to be statistically significant. The worst results were achieved in ischemia group (p < .05). Treatments groups showed nearly similar findings with this group (p < .05). There was no significant difference between control and sham groups. In this study, we found that apart from the other members of the PDE inhibitors' family, enoximone did not contribute to the attenuation of IR injury of kidney.

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“…O mesmo efeito foi observado em cães, nos quais a dose de 1,2µg/kg/min aumentou em 38% o fluxo sanguíneo renal, sem alterar a pressão sanguínea arterial (McNay et al, 1965). Baixas doses de dopamina estimulam receptores D1 no leito vascular renal, induzindo a vasodilatação e aumento do fluxo sanguíneo renal (Tobata et al, 2004), mas doses altas, capazes de estimular receptores α-adrenérgicos, levam a vasoconstrição renal e de outros efeitos vasculares (Furukawa et al, 2002). Enquanto a estimulação de receptores D1 causa vasodilatação de forma direta, mediada pela via AMPc/PKA, a ação dos receptores tipo D2 é um pouco mais complexa.…”

Section: Introductionunclassified

Avaliação Da Função Glomerular De Cães Sadios E Nefropatas Sob Estimulação Dopaminérgica

Brum

Carvalho

Pereira³

2010

AVS

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RESUMO:A dopamina é um composto endógeno amplamente utilizado em terapia intensiva. Possui um amplo espectro de ações, tanto sobre o sistema cardiovascular como urinário. Aumento da taxa de filtração glomerular, do fluxo sangüíneo renal e excreção fracionada de sódio e fósforo são efeitos renais esperados em indivíduos normais, porém são pouco explorados na medicina veterinária. Este estudo foi conduzido com o propósito de avaliar a função glomerular de cães nefropatas crônicos submetidos à infusão contínua de dopamina. Diferentes doses de dopamina foram administradas em cães nefropatas. Avaliações laboratoriais de clearance de creatinina e a razão proteína/creatinina urinária foram realizadas durante e após os tratamentos. O clearance de creatinina apresentou aumento dose-dependente nos cães sadios. Em cães nefropatas, a dose de 1µg/kg/min aumentou discretamente a TFG, sem modificar a U-P/C e pressão arterial sistêmica, enquanto a dose de 3µg/kg/min promoveu aumento da excreção urinária de proteínas. Palavras-chave: cão; dopamina; insuficiência renal crônica; proteinúria; taxa de filtração glomerular EVALUATION OF GLOMERULAR FUNCTION IN HEALTHY AND NEPHROPATHIC DOGS UNDER DOPAMINERGIC STIMULATIONABSTRACT: Dopamine is an endogenous compound widely used in intensive care. It has a broad spectrum of action, on the cardiovascular system and urinary tract. Increased glomerular filtration rate, renal blood flow and fractional excretion of sodium and phosphorus are expected renal effects in normal individuals, but are poorly explored in veterinary medicine. This study was conducted to evaluate the glomerular function of dogs with renal disease submitted to continuous infusion of dopamine. Different doses of dopamine were administered in healthy and nephropathic dogs. Laboratory evaluations of creatinine clearance and urinary protein/creatinine ratio were performed during and after treatments. Creatinine clearance showed dose-dependent increase in healthy dogs. In dogs with renal disease, the dose of 1µg/kg/min GFR increased slightly, without changing the urine P/C and blood pressure, while the dose of 3µg/kg/min increased urinary protein excretion.

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Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

Cited by 23 publications

References 30 publications

Vasoactive drugs and the gut: is there anything new?

Vasoactive drugs and the gut: is there anything new?

Apart from the Other Members of PDE Inhibitors' Family, Enoximone Does Not Enhance Renal Ischemic Reperfusion Injury: The Effects of Enoximone on Renal Ischemia Reperfusion

Avaliação Da Função Glomerular De Cães Sadios E Nefropatas Sob Estimulação Dopaminérgica

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