Direct opto-acoustic<i>in vitro</i>measurement of the spatial distribution of laser radiation in biological media

Pelivanov, Ivan; Белов, С.А.; Solomatin, Vladimir S; Khokhlova, Tanya D.; Карабутов, А.А.

doi:10.1070/qe2006v036n12abeh013261

Cited by 25 publications

(15 citation statements)

References 12 publications

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“…To study the applicability of the OA method for monitoring the HIFU therapy, it is necessary érst of all to measure the absorption m a and effective attenuation m eff (3m a m H s ) 1a2 coefécients of a biological tissue [15] [where m H s m s (1 À g) in the reduced scattering coefécient and g is the scattering anisotropy factor] before and after coagulation caused by ultrasonic heating. As a biological tissue we used a porcine liver.…”

Section: Methodsmentioning

confidence: 99%

Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

et al. 2006

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Section: Methodsmentioning

confidence: 99%

Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

et al. 2006

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“…This would produce a PA signal with an amplitude of a few MPa. 39 Taking into consideration ultrasound attenuation and diffraction loss during propagation, 14,40 and a limited frequency band of detection, the amplitude would be reduced by at least four orders of magnitude. 25,28,41 However, a focused thin-film PVDF-based transducer can detect a pressure signal on the level of ten Pa 14,25 for frequencies up to 10 MHz.…”

Section: Discussionmentioning

confidence: 99%

“…12 In particular, the distribution of laser fluence inside the object under study cannot be considered the same at different wavelengths. [13][14][15][16] This makes solution of the inverse problem quite ambiguous.…”

Section: Introductionmentioning

confidence: 99%

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

et al. 2012

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Abstract. Contrast-enhanced photoacoustic (PA) imaging has been proposed to identify circulating metastatic cancer cells magnetically trapped in the vasculature. However, its sensitivity is limited by the presence of a strong blood-background signal. This technique can be further improved by the significant suppression of blood background. In the phantom study presented here, significant background suppression is demonstrated with magnetomotive photoacoustic imaging. Magnetic particles with a mean diameter of 10 μm were integrated (concentration of 0.05 mg∕ml) into an ink-water solution with an optical absorption coefficient of 5 cm −1 to mimic cells targeted with magnetic nanoparticles and magnetically trapped in the human vasculature. Two mechanically moveable permanent magnets were used to accumulate microparticles in the investigated solution and manipulate them within a thin, 1.6-mm-diameter Teflon tube mimicking a blood vessel. Our results clearly indicate that the undesirable background can be effectively suppressed using the difference of PA images corresponding to different locations of accumulated particles.

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“…Fig. 2 shows the transient response of the transducer in time and its frequency spectrum (measured in K 2 CrO 4 solution (concentration 13 mg/cm 3 , and absorption coefficient ∼1000 cm…”

Section: Time-resolved Photoacoustic Measurementmentioning

confidence: 99%

“…In this study, we applied a form of photoacoustic technique based on time-resolved stress detection. Used originally in biomedical optics to study tissues [2,3], this technique can be used to deduce the effective attenuation coefficient of a pulp suspension. At the same time, by determining the total diffuse reflectance from a sample, we can obtain the ratio of its absorption and reduced scattering coefficients.…”

Section: Introductionmentioning

confidence: 99%

Determination of optical parameters of pulp suspensions by time-resolved detection of photoacoustic signals and total diffuse reflectance measurements

2010

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Abstract:Time-resolved photoacoustics were used to measure the optical parameters of pulp suspensions for the first time. Reconstructing stress distribution along the direction of the incident laser light allows the effective attenuation coefficient of these suspensions to be determined. Simultaneously, the total diffuse reflectance of the suspensions was measured by the same laser source. Based on the effective attenuation coefficient and total diffuse reflectance, the absorption and reduced scattering coefficients of pulp suspensions can be calculated. In this study, three kinds of pulp suspensions with different kappa number (2, 13, and 16), a measure of lignin content in pulp fibers, were diluted with water to make samples with a consistency range from 1% to 5%, and studied at 355 nm wavelength. The results showed that the optical coefficients were approximately proportional to pulp consistency; on the other hand, the absorption coefficient was linearly correlated with kappa number, but the reduced scattering coefficient was not. Therefore, by determining its optical parameters, it is possible to extract the consistency and kappa number of an unknown pulp suspension.

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Direct opto-acousticin vitromeasurement of the spatial distribution of laser radiation in biological media

Cited by 25 publications

References 12 publications

Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

Determination of optical parameters of pulp suspensions by time-resolved detection of photoacoustic signals and total diffuse reflectance measurements

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