Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

Khokhlova, Tanya D.; Pelivanov, Ivan; Sapozhnikov, Oleg A.; Solomatin, Vladimir S; Карабутов, А.А.

doi:10.1070/qe2006v036n12abeh013262

Cited by 35 publications

(43 citation statements)

References 19 publications

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“…A study from Nilsson et al (1998) demonstrated 100% to 300% increase in optical absorption and 120% to 280% increase in reduced scattering coefficient (for 600-1500 nm) in necrotic and normal rat liver in vivo. Similar trends were reported for ex vivo porcine liver (Khokhlova et al 2006) and chicken breast (Ben-David et al 2008) at wavelengths of 1064 and 1041 nm, respectively. Three major mechanisms have been proposed for the observed increases in optical absorption and scattering.…”

Section: Acousto-optic Imaging (Aoi)supporting

confidence: 85%

Real-Time Monitoring of High-Intensity Focused Ultrasound Lesion Formation Using Acousto-Optic Sensing

Lai

McLaughlan

Draudt

et al. 2011

Ultrasound in Medicine & Biology

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High-intensity focused ultrasound (HIFU) is a promising modality that is used to noninvasively ablate soft tissue tumors. Nevertheless, real-time treatment monitoring with diagnostic ultrasound still poses a significant challenge since tissue necrosis, in the absence of cavitation or boiling, provides little acoustic contrast with normal tissue. In comparison, the optical properties of tissue are significantly altered accompanying lesion formation. A photorefractive crystal-based acousto-optic (AO) sensing system that uses a single HIFU transducer to simultaneously generate tissue necrosis and pump the AO interaction is used to monitor the real-time optical changes associated with thermal lesions induced in chicken breast ex vivo. It is found that the normalized change in AO response increases proportionally with the volume of necrosis. This study demonstrates AO sensing can identify the onset and growth of lesion formation in real time and, when used as feedback to guide exposures, results in more predictable lesion formation.

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Section: Acousto-optic Imaging (Aoi)supporting

confidence: 85%

Real-Time Monitoring of High-Intensity Focused Ultrasound Lesion Formation Using Acousto-Optic Sensing

Lai

McLaughlan

Draudt

et al. 2011

Ultrasound in Medicine & Biology

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“…This is consistent with the changes in optical properties of soft tissues reported in the literature. 1,21,37 In the experimental results given in Fig. 8, the normalized change in AO signal magnitude DS n was observed to be highly correlated with lesion volume under a wide variety of exposure conditions, with DS n increasing monotonically with lesion volume.…”

Section: Hifu Monitoringmentioning

confidence: 82%

“…Moreover, the optical properties of tissue have been shown to vary markedly in between normal and necrotic tissues, with necrotic tissue showing increased absorption and scattering and the specific increase dependent on tissue type. 1,21,37 The HIFU monitoring results demonstrate that real-time monitoring of lesion formation and growth is possible using AOI combined with lock-in detection.…”

Section: Hifu Monitoringmentioning

confidence: 95%

Measuring Tissue Properties and Monitoring Therapeutic Responses Using Acousto-Optic Imaging

2011

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Acousto-optic imaging is a hybrid imaging technique that exploits the interaction between light and sound to image optical contrast at depth in optically turbid media with the high spatial resolution of ultrasound. Quantitative measurement of optical properties using this technique is confounded by multiple parameters that influence the detected acousto-optic signal. In this article, we describe the origin of the acousto-optic response and review techniques that have been proposed to relate this response to the optical properties of turbid media. We present an overview of two acousto-optic sensing approaches. In the first, we demonstrate that the local transport mean free path within turbid media can be obtained by varying the pressure of the ultrasound field and processing the resulting acousto-optic signals. In the second, we demonstrate that the acousto-optic response elicited by a high-intensity ultrasound field during thermal therapy can be used to monitor the onset of lesion formation, ascertain lesion volume, and provide real-time control of exposure duration.

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“…The increase in the amplitude of photoacoustic signals after HIFU treatment is consistent with previous results. 16,17 The increase in the amplitude of photoacoustic signals after HIFU can be attributed to a combination of several factors. Notably, the Grüneisen parameter is affected by tissue coagulation.…”

Section: Methodsmentioning

confidence: 99%

“…15 PAI has demonstrated to be capable of monitoring thermal lesions generated by HIFU or other means. 16,17 A study for PAI guidance of HIFU has also been proposed with the application of a time-reversal technique. 18 Currently, PAI and HIFU are performed by two separate systems.…”

Section: Introductionmentioning

confidence: 99%

The integration of photoacoustic imaging and high intensity focused ultrasound

Cui

Staley

Yang

2010

Photons Plus Ultrasound: Imaging and Sensing 2010

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Abstract.We have developed an integrated photoacoustic imaging ͑PAI͒ and high-intensity focused ultrasound ͑HIFU͒ system for solid tumor treatments. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5 MHz, was used to induce HIFU lesions in soft tissue. The same ultrasonic transducer was also used as a detector during PAI to guide HIFU ablation. The use of same transducer for PAI and HIFU can reduce the requirement on acoustic windows during the imaging-guided therapy, as well as ensuring the correct alignment between the therapeutic beam and the planned treatment volume. During an experiment, targeted soft tissue was first imaged by PAI. The resulted image was used to plan the subsequent HIFU ablation. After the HIFU ablation, targeted soft tissue was imaged again by PAI to evaluate the effectiveness of treatments. Good contrast was obtained between photoacoustic images before and after HIFU ablation. In conclusion, our results demonstrated that PAI technology may potentially be integrated with HIFU ablation for imageguided therapy.

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Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments

Abstract: View the article online for updates and enhancements.

Cited by 35 publications

References 19 publications

Real-Time Monitoring of High-Intensity Focused Ultrasound Lesion Formation Using Acousto-Optic Sensing

Real-Time Monitoring of High-Intensity Focused Ultrasound Lesion Formation Using Acousto-Optic Sensing

Measuring Tissue Properties and Monitoring Therapeutic Responses Using Acousto-Optic Imaging

The integration of photoacoustic imaging and high intensity focused ultrasound

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