Diquertin suppresses ADP- and thrombin-induced accumulation of cytoplasmic calcium in human thrombocytes

Кубатиев, Аслан Амирханович; Yadigarova, Z. T.; Rud'ko, I. A.; Tyukavkina, N. A.; Быков, В. А.

doi:10.1007/bf02974935

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Our study showed that α-LA and DHQ possess antiplatelet activity in the concentration range reported by other authors. [7111216] α-LA had a higher antiplatelet activity than DHQ. From the data presented in the Table 1, IC 50 values of 0.69 ± 0.03 and 3.76 ± 0.42 mM for α-LA and DHQ were calculated.…”

Section: Discussionmentioning

confidence: 96%

“…[712] α-LA (0.3-0.8 mM) dose-dependently inhibited platelet aggregation induced by collagen, ADP, or arachidonic acid. [7] Investigators link the antiplatelet activity of α-LA with an elevation of cyclic adenosine monophosphate (cAMP) formation, involving the subsequent inhibition of Thromboxane A2 (TXA 2 ), cyclooxygenase-1, protein kinase Cα-mediated pathways, peroxisome proliferator-activated receptors (PPARγ), Ca 2+ mobilization and inhibition of reactive oxygen species formation, and the increase of platelet membrane fluidity.…”

Section: Discussionmentioning

confidence: 99%

“…Kubatiev et al ., showed that DHQ produced the decrease in the levels of both base and ADP- or thrombin-induced cytoplasmic Ca 2+ levels and elevated cAMP and cyclic guanosine monophosphate (cGMP) contents in native and thrombin-activated platelets. [1112]…”

Section: Discussionmentioning

confidence: 99%

“…[910] Moreoever, antiplatelet activity of DHQ has been observed by Kubatiev et al . [1112] Thus, the objective of the study was to investigate the antiplatelet activity of α-LA and DHQ and their combined use.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

et al. 2014

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Objectives:To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).Materials andMethods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10-5 M.Results:α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.Conclusion:Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

et al. 2014

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“…Similarly, TX inhibits platelet aggregation induced by ADP and thrombin release [ 95 ]. Kubatiev et al showed that TX causes a concentration-dependent decrease in cytoplasmic Ca 2+ levels in thrombocytes induced by ADP or thrombin probably via the Ca 2+ inhibition channels [ 94 ]. Higher concentrations of TX decreased the basal cytoplasmatic Ca 2+ concentration probably due to the elevation in the cAMP level.…”

Section: Cellular and Molecular Mechanisms Of Ec And Tx Action Relmentioning

confidence: 99%

Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

Bernátová

Líšková

2021

Antioxidants

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Various studies have shown that certain flavonoids, flavonoid-containing plant extracts, and foods can improve human health. Experimental studies showed that flavonoids have the capacity to alter physiological processes as well as cellular and molecular mechanisms associated with their antioxidant properties. An important function of flavonoids was determined in the cardiovascular system, namely their capacity to lower blood pressure and to improve endothelial function. (−)-Epicatechin and taxifolin are two flavonoids with notable antihypertensive effects and multiple beneficial actions in the cardiovascular system, but they also possess antiviral effects, which may be of particular importance in the ongoing pandemic situation. Thus, this review is focused on the current knowledge of (−)-epicatechin as well as (+)-taxifolin and/or (−)-taxifolin-modified biological action and underlining molecular mechanisms determined in preclinical studies, which are relevant not only to the treatment of hypertension per se but may provide additional antiviral benefits that could be relevant to the treatment of hypertensive subjects with SARS-CoV-2 infection.

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Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection

Chen

Sharda

et al. 2021

Pharmacological Research

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Diquertin suppresses ADP- and thrombin-induced accumulation of cytoplasmic calcium in human thrombocytes

Cited by 3 publications

References 6 publications

Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection

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