Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Иванов, И. С.; Sidehmenova, Anastasia V; Smol’yakova, V. I.; Чернышева, Г. А.; Mb, Plotnikov

doi:10.4103/0253-7613.135958

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…These effects may be relevant for the treatment of hypertension and viral infections through improvements in peripheral vascular function and anti-inflammatory activity [ 107 ]. Reported effects on peripheral vascular function and cardioprotective- and anti-inflammatory effects are summarized in Table 8 [ 107 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ]. References to the cellular and molecular mechanisms underlying the biological effects of epicatechin and taxifolin are listed in Table 9 [ 107 , 115 , 119 , 123 , 128 , 130 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 ,…”

Section: The Effects Of Dietary Flavonoids On Microvascular Healthmentioning

confidence: 99%

Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles

Komai,

Takeno,

Fujii

et al. 2024

Nutrients

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Since the 1970s, the utility of nailfold capillaroscopy (NFC) in diagnosing rheumatological disorders such as systemic sclerosis has been well established. Further studies have also shown that NFC can detect non-rheumatic diseases such as diabetes, glaucoma, dermatitis, and Alzheimer disease. In the past decade, nailfold capillary morphological changes have also been reported as symptoms of unhealthy lifestyle habits such as poor diet, smoking, sleep deprivation, and even psychological stress, all of which contribute to slow blood flow. Therefore, studying the relationships between the morphology of nailfold capillaries and lifestyle habits has a high potential to indicate unhealthy states or even pre-disease conditions. Simple, inexpensive, and non-invasive methods such as NFC are important and useful for routine medical examinations. The present study began with a systematic literature search of the PubMed database followed by a summary of studies reporting the assessment of morphological changes detected by NFC, and a comprehensive review of NFC’s utility in clinical diagnosis and improving unhealthy dietary lifestyles. It culminates in a summary of dietary and lifestyle health promotion strategy, assessed based on NFC and other related measurements that indicate healthy microvascular blood flow and endothelial function.

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Section: The Effects Of Dietary Flavonoids On Microvascular Healthmentioning

confidence: 99%

Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles

Komai,

Takeno,

Fujii

et al. 2024

Nutrients

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“…Similarly, TX inhibits platelet aggregation induced by ADP and thrombin release [ 95 ]. Kubatiev et al showed that TX causes a concentration-dependent decrease in cytoplasmic Ca 2+ levels in thrombocytes induced by ADP or thrombin probably via the Ca 2+ inhibition channels [ 94 ].…”

Section: Cellular and Molecular Mechanisms Of Ec And Tx Action Relmentioning

confidence: 99%

Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

Bernátová

Líšková

2021

Antioxidants

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Various studies have shown that certain flavonoids, flavonoid-containing plant extracts, and foods can improve human health. Experimental studies showed that flavonoids have the capacity to alter physiological processes as well as cellular and molecular mechanisms associated with their antioxidant properties. An important function of flavonoids was determined in the cardiovascular system, namely their capacity to lower blood pressure and to improve endothelial function. (−)-Epicatechin and taxifolin are two flavonoids with notable antihypertensive effects and multiple beneficial actions in the cardiovascular system, but they also possess antiviral effects, which may be of particular importance in the ongoing pandemic situation. Thus, this review is focused on the current knowledge of (−)-epicatechin as well as (+)-taxifolin and/or (−)-taxifolin-modified biological action and underlining molecular mechanisms determined in preclinical studies, which are relevant not only to the treatment of hypertension per se but may provide additional antiviral benefits that could be relevant to the treatment of hypertensive subjects with SARS-CoV-2 infection.

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“…Taxifolin (TAX), a dihydro avonol, is an important natural active ingredient, which has generally been isolated from larch root. In view of its structure containing more phenolic hydroxyl groups, TAX has a variety of biological activities, including anti-in ammatory, antioxidant, anti-proliferation and antianaphylaxis effects (Kim et al 2008;Ahn et al 2010;Ivanov et al 2014) Therefore, TAX has high development potential, such as food additives, health foods and medicines. TAX was rst extracted from Douglas r bark by Japanese scholars using hot water extraction (Fukui et al 1966).…”

Section: Introductionmentioning

confidence: 99%

Establishment of callus induction system, histological evaluation and taxifolin production of Larch

Liu

Zhao

Chen

et al. 2021

Plant Cell Tiss Organ Cult

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Taxifolin in larch is an important natural active ingredient, which prevents and treats liver diseases and cardiovascular diseases, and has many health bene ts and application values such as anti-tumor, antivirus, and anti-aging. However, the traditional extraction method is not conducive to the protection of the ecological environment, and also limits the industrial production of taxifolin from larch. Therefore, the purpose of this research is to establish a larch callus culture system and obtain taxifolin from callus. The shoots of the stem-tips of Larix olgensis were used as explants to be cultured. The light conditions, optimal medium and hormone ratio for callus induction were screened to evaluate the callus induction characteristics of larch and its in uence on the accumulation of taxifolin. The results showed that: callus formation started on 28-51 days, and the best conditions for inducing callus were explored: 12 h/d light culture MS + 2,4-D 2 mg/L + 6-BA 1 mg/ L + KT 0.1 mg/L; the callus induction rate is 50%-80%; the highest condition for producing taxifolin 6-BA 1 mg/L + NAA 0.1 mg/L, reaching 0.414%. In conclusion, this study represents a suitable induction condition for larch callus culture and taxifolin accumulation. Key MessageIn this study, a stable and e cient larch callus culture system was established to lay the foundation for the industrial production of taxifolin, which may also be the best strategy for obtaining taxifolin in the future.

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Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

Cited by 7 publications

References 16 publications

Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles

Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles

Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

Establishment of callus induction system, histological evaluation and taxifolin production of Larch

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