Diosmin – Isolation Techniques, Determination in Plant Material and Pharmaceutical Formulations, and Clinical Use

Bogucka‐Kocka, Anna; Woźniak, Michał; Feldo, Marcin; Kockic, Janusz; Szewczyk, Katarzyna

doi:10.1177/1934578x1300800435

Cited by 39 publications

(34 citation statements)

References 39 publications

(11 reference statements)

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“…Several studies have demonstrated that, due to its free radical scavenging and anti-inflammatory effects, diosmin exhibits therapeutic effects against cardiovascular disorders. A reduction of oxidative stress and apoptotic cell death in endothelial cells and cardiomyocytes has been shown (Bogucka-Kocka et al, 2013;Senthamizhselvan et al, 2014;Silambarasan and Raja, 2012). In epithelial cells, it was demonstrated that diosmin suppressed oxidative damage and subsequent apoptosis in a dose dependent manner via a decrease of the Bax/Bcl-2 ratio, cytochrome c release into the cytosol and subsequent inhibition of caspase-3.…”

Section: Diosmin and Diosmetinmentioning

confidence: 99%

“…Diosmin (diosmetin 7-O-rutinoside) ( Figure 1) was first isolated from leaves of Scrophularia nodosa L., (Scrophulariaceae) in 1925. Later studies revealed that diosmin occurred abundantly in the pericarp (Bogucka-Kocka et al, 2013;Patel et al, 2013;Singhal et al, 2017;Yao et al, 2018) but also in the pulp and juice of different citrus fruits species (e.g., Citrus sinensis, C. clementina, C. aurantium, C. limon, C. aurantifolia and C. bergamia (Gattuso et al, 2007). A comparative study analyzing 42 Citrus species showed specific differences in levels of diosmin in pericarp, pulp and juice throughout the different species.…”

Section: Diosmin and Diosmetinmentioning

confidence: 99%

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The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Gosslau¹,

Ho²,

Li³

2019

JFB

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Chronic inflammation and dysregulation of apoptotic pathways leading to free radical-induced tissue damage are widely recognized as major underlying causes of major degenerative diseases, including cancer, diabetes, neurological and cardiovascular disorders. Citrus fruits are rich sources of polyphenolic flavonoids well known for their wide range of pharmacological properties. Rutin (quercetin-3-O-rutinoside) and diosmin (diosmetin 7-Orutinoside) are two major polyhydroxyflavone glycosides abundantly found in citrus peels and, to a lesser extent, in pulp of a variety of different citrus species. During digestion, hydrolysis by intestinal enzymes and gut microbiota lead to the release of their corresponding bioactive aglycones (e.g., quercetin or diosmetin). Data obtained in cell-based, animal and clinical studies demonstrated strong preventive and/or therapeutic effects of rutin and its aglycone flavone quercetin. Although lesser studies available, our recent literature review suggests diosmin as promising citrus fruit polyhydroxyflavonoids, effective against various diseases associated with chronic inflammation.

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Section: Diosmin and Diosmetinmentioning

confidence: 99%

Section: Diosmin and Diosmetinmentioning

confidence: 99%

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Gosslau¹,

Ho²,

Li³

2019

JFB

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“…1A) and the flavanon glycoside (Fig. 1B) possess vasoprotective and venotonic properties (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Diosmin differs from hesperidin by a double bond present in the structure of the former between C 2 and C 3 ( Fig.…”

Section: Structure Sources and Isolationmentioning

confidence: 99%

“…1) (1)(2)(3). Although both glycosides are naturally occurring in the families of Rutaceae, Lamiaceae, Apiaceae, Scrophulariaceae (S. nadosa) (2)(3)(4)(5)(6)(7)(8)(9)(10), the industrial sector uses semisynthetic diosmin derived from hesperidin by a suitable oxidation reaction (I 2 /pyridine, I 2 /dimethylsulfoxide or other) (1)(2)(3)11,(15)(16)(17)(18). Hesperidin is most commonly isolated from dry orange or citrus peels (Citrus sinesis, L., Citrus aurantium, L., Citrus lemon, L., and other Citrus species) (3,8,10).…”

Section: Structure Sources and Isolationmentioning

confidence: 99%

Biopharmaceutical and marketing evaluation of diosmin- and hesperidin-containing products on the Bulgarian market

Ivanova

Hyusein

Slavov

et al. 2019

Scripta Scientifica Pharmaceutica

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INTRODUCTION: Diosmin and hesperidin are commonly used flavonoids in the therapy of vascular diseases. AIM: This study aimed to present an independent evaluation of the market status, quality and biopharmaceutical characteristics of diosmin-and hesperidin-containing oral tablet-products (DHCPs) on the Bulgarian market. MATERIALS AND METHODS: Seven products, among which medicines (used as reference) and food supplements, with sustainable or growing market were selected for the survey: Detralex 500 mg, Phlebodia 600 mg, Dioket 600 mg, Novarix 650 mg, Asketon 500 mg, Venocode and Dih max 1000 mg. Sales analysis for 2016, 2017 and 2018 (year-to-date) was done with the kind support of Iqvia TM. All products were subjected to European Pharmacopoeia (EP) tests for tablet quality-disintegration, resistance to crushing, uniformity of mass and uniformity of dosage units. Biopharmaceutical profile regarding tablet drug release and dissolution potency was investigated on EP Apparatus 2 (Paddle method). RESULTS: Although all products were found to almost fully fulfill the EP criteria, extremely unsatisfying drug release was established in all tested media (pH 1,5, pH 4,5 and pH 7,2), reaching not more than 1.6% of the labeled content after 24 hours for the best performing products-Novarix and Venocode. CONCLUSION: These results were not surprising considering diosmin and hesperidin's water insolubility and respective low bioavailability. However, it would be reasonable to approach these two bioactive compounds technologically in preformulation stage in order to improve their solubility and therapeutic potency.

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“…This component is also syntesed other bioflavinoid such as hesperidine. Closed formula is C 30 O 12 H 31 and also referred to as diosmetin 7‐O‐rutinoside or 5,7,3‐trihydroxy‐4‐ethoxyplavone‐7‐ramnoglycoside (Bogucka‐Kocka, Woźniak, Feldo, Kockic, & Szewczyk, ; Russo et al, ; Tripoli, Guardia, Giammanco, Majo, & Giammanco, ). Some flavonoids, including diosmin, are potent inhibitors of prostaglandin E 2 and thromboxane A 2 .…”

Section: Introductionmentioning

confidence: 99%

The effect of diosmin against liver damage caused by cadmium in rats

Ağır

Eraslan

2019

J Food Biochem

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A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase) and oxidative stress parameters (malondialdehyde [MDA], nitric oxide [NO], superoxide dismutase [SOD], catalase [CAT], gluthatione peroxidase [GSH‐Px], and glutathione [GSH]) were analyzed in the samples. Histo‐pathological findings were evaluated in the liver. The body weights and liver weights of the animals were measured. The MDA and NO levels and biochemical enzyme activities examined were increased, whereas SOD, CAT, and GSH‐Px activities and GSH levels decreased in cadmium‐exposed group. There were also negative changes in body weight, liver weight, and liver tissue histo‐phathology. Positive improvements were observed in all these parameters evaluated of the group co‐administered cadmium and diosmin. Practical applications Cadmium is one of the common environmental pollutants. Diosmin is a type of flavonoid found mainly in citrus fruits. It can also be produced from hesperidine. This compound is used for medical purposes and also has strong antioxidant properties. One of the toxic effects mechanisms of cadmium is oxidative stress and causes liver damage with different pathways. This compound can be used as a supporting agent in addition to the main treatment options against liver damage in case of exposure to possible cadmium. This flavonoid can also be taken with food for prophylactic purposes.

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Diosmin – Isolation Techniques, Determination in Plant Material and Pharmaceutical Formulations, and Clinical Use

Cited by 39 publications

References 39 publications

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment

Biopharmaceutical and marketing evaluation of diosmin- and hesperidin-containing products on the Bulgarian market

The effect of diosmin against liver damage caused by cadmium in rats

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