The effect of diosmin against liver damage caused by cadmium in rats

Abstract

A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase) and oxidative stress parameters (malondialdehyde [MDA], nitric oxide [NO], superoxide dismutase [SOD], catalase [CAT], gluthatione peroxidase [GSH‐Px], and glutathione [GSH]) were analyzed in the samples. Histo‐pathological findings were evaluated in the liver. The body weights and liver weights of the animals were measured. The MDA and NO levels and biochemical enzyme activities examined were increased, whereas SOD, CAT, and GSH‐Px activities and GSH levels decreased in cadmium‐exposed group. There were also negative changes in body weight, liver weight, and liver tissue histo‐phathology. Positive improvements were observed in all these parameters evaluated of the group co‐administered cadmium and diosmin. Practical applications Cadmium is one of the common environmental pollutants. Diosmin is a type of flavonoid found mainly in citrus fruits. It can also be produced from hesperidine. This compound is used for medical purposes and also has strong antioxidant properties. One of the toxic effects mechanisms of cadmium is oxidative stress and causes liver damage with different pathways. This compound can be used as a supporting agent in addition to the main treatment options against liver damage in case of exposure to possible cadmium. This flavonoid can also be taken with food for prophylactic purposes.

Correction of Morphofunctional Disorders in Experimental Preeclampsy by Combined Use of Trimetazidine and Purified Micronized Flavonoid Fraction as Well as Their Combinations With Methylampsy

“…Кроме этого, диосмин способен снижать индуцированную выработку NO путем ингибирования еNOS [48,53]. К антиоксидантной активности можно отнести способность исследуемого препарата повышать активность глутатионпероксидазы, супероксиддисмутазы, каталазы [53,55,56] и предотвращать перекисное окисление липидов с повышением активности антиоксидантной системы [56,57]. Снижение образования провоспалительных цитокинов и маркеров оксидативного стресса приводит не только к уменьшению повреждения непосредственно тканей плаценты, но и улучшению функции эндотелия.…”

Natural products for the prevention and treatment of cholestasis: A review

“…Diosmin is a citrus flavone with a specific protective effect against hepatic, cardiac, and renal diseases (Ağır & Eraslan, ; Figure 2a). In recent years, a wide range of studies have confirmed that it has various pharmacological activities along with its antioxidant, antiapoptotic, and antiinflammatory properties (Eraslan et al, ).…”

Hepatoprotective potential of diosmin against hepatotoxic effect of isoniazid and rifampin in wistar rats

“…15,16 A recent study has reported that diosmin has protective effect against cadmium induced liver damage. 17 It is also reported that diosmin is commonly used to treat hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory problems due to inadequate blood supply. 18 There is no appropriate drug available in the market to treat anti-tubercular drug induced hepatotoxicity.…”