A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase) and oxidative stress parameters (malondialdehyde [MDA], nitric oxide [NO], superoxide dismutase [SOD], catalase [CAT], gluthatione peroxidase [GSH‐Px], and glutathione [GSH]) were analyzed in the samples. Histo‐pathological findings were evaluated in the liver. The body weights and liver weights of the animals were measured. The MDA and NO levels and biochemical enzyme activities examined were increased, whereas SOD, CAT, and GSH‐Px activities and GSH levels decreased in cadmium‐exposed group. There were also negative changes in body weight, liver weight, and liver tissue histo‐phathology. Positive improvements were observed in all these parameters evaluated of the group co‐administered cadmium and diosmin. Practical applications Cadmium is one of the common environmental pollutants. Diosmin is a type of flavonoid found mainly in citrus fruits. It can also be produced from hesperidine. This compound is used for medical purposes and also has strong antioxidant properties. One of the toxic effects mechanisms of cadmium is oxidative stress and causes liver damage with different pathways. This compound can be used as a supporting agent in addition to the main treatment options against liver damage in case of exposure to possible cadmium. This flavonoid can also be taken with food for prophylactic purposes.