Diosgenin, neoruscogenin, and ruscogenin from Ruscus ponticus, R. hypophyllum, and Allium albidum

Pkheidze, T. A.; Kereselidze, E. V.; Кемертелидзе, Э. П.

doi:10.1007/bf00567962

Cited by 8 publications

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“…Ex M. Bieb. Diosgenin [ 4 ] Kereselidze et al ( 1970 ) Hecogenin [ 7 ] Kravets et al ( 1990 ) Ruscogenin [ 17 ] Pkheidze et al ( 1971 ) A. albiflorus Saponins present Ismailov and Aliev ( 1976 ) A. albopilosum C.H. Wright Agigenin [ 34 ] Mimaki et al ( 1993 ) Neoagigenin [ 36 ] Mimaki et al ( 1993 ) Alliogenin [ 49 ] Mimaki et al ( 1993 ) AGINOSIDE [ 93 ] Agigenin [ 34 ] 3- O -β- d -Glc-(1 → 2)-[β- d -Xyl-(1 → 3)]- O -β- d -Glc-(1 → 4)- O -β- d -Gal Mimaki et al ( 1993 ) [ 94 , 123 ] (25 R , S )-5α-spirostane-2α,3β,6β-triol [ 34 , 36 ] 3- O -β- d -Glc-(1 → 2)-[3- O -acetyl-β- d -Xyl-(1 → 3)]- O -β- d -Glc-(1 → 4)- O -β- d -Gal Mimaki et al ( 1993 ) ...…”

Section: Chemistry Of Allium Saponinsmentioning

confidence: 99%

Steroidal saponins from the genus Allium

et al. 2014

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Steroidal saponins are widely distributed among monocots, including the Amaryllidaceae family to which the Allium genus is currently classified. Apart from sulfur compounds, these are important biologically active molecules that are considered to be responsible for the observed activity of Allium species, including antifungal, cytotoxic, enzyme-inhibitory, and other. In this paper, literature data concerning chemistry and biological activity of steroidal saponins from the Allium genus has been reviewed.Electronic supplementary materialThe online version of this article (doi:10.1007/s11101-014-9381-1) contains supplementary material, which is available to authorized users.

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Section: Chemistry Of Allium Saponinsmentioning

confidence: 99%

Steroidal saponins from the genus Allium

et al. 2014

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“…Notwithstanding this, few phytochemical studies on R. ponticus are reported in literature: so far only diosgenin and neoruscogenin were found in the roots of R. ponticus (Pkheidze et al, 1971), along with steroidal glycosides namely ruscoponticosides C, D, and E (Korkashvili et al, 1985). Furthermore, there is only one report about the steroidal composition of the leaves of R. ponticus (Pkheidze et al, 1970).…”

Section: Introductionmentioning

confidence: 95%

Steroidal glycosides from Ruscus ponticus

Napolitano

Muzashvili²,

Perrone

et al. 2011

Phytochemistry

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“…4). From the cladophylls of R. hypoglossum, four neoruscogenin derivatives (34)(35)(36)(37) have been isolated [35] (l " Fig. 4).…”

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confidence: 99%

“…A phytochemical investigation of the roots of R. ponticus led to the isolation of diosgenin and neoruscogenin (1) [37], along with ruscoponticosides C (4) and D (3) [38]. The 13 Furostanol saponins from Ruscus spp.…”

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confidence: 99%

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Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

2016

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The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher?s broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp. extracts. The underground parts of Ruscus plants are a source of steroidal saponins that can be classified into two structural classes: the hexacyclic spirostanol saponins and the pentacyclic furostanol saponins. The main aglycones are ruscogenin and neoruscogenin. From the pharmacological point of view, the most studied Ruscus species is undoubtedly R.?aculeatus, a very ancient phlebotherapeutic agent. Pharmacological investigations since the discovery of the vasoconstrictive and venotonic properties of ruscogenin and neoruscogenin in the underground parts of R.?aculeatus are discussed. Preparations based on Ruscus species are currently used for the treatment of chronic venous insufficiency, varicose veins, haemorrhoids, and orthostatic hypotension. Finally, analytical techniques for the quality control of R.?aculeatus extracts are reported.

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Diosgenin, neoruscogenin, and ruscogenin from Ruscus ponticus, R. hypophyllum, and Allium albidum

Cited by 8 publications

References 2 publications

Steroidal saponins from the genus Allium

Steroidal saponins from the genus Allium

Steroidal glycosides from Ruscus ponticus

Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

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