Steroidal glycosides from Ruscus ponticus

Napolitano, Assunta; Muzashvili, T; Perrone, Angela; Pìzza, Cosimo; Кемертелидзе, Э. П.; Piacente, Sonia

doi:10.1016/j.phytochem.2011.01.033

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…In 1972, two pregnane glycosides (116 and 117) were identified in the rhizomes of R. aculeatus [51]. Compound 116 was also isolated from R. hypoglossum [24], while more recently compounds 117 and 118 were identified in the underground parts of R. ponticus [6] (l " Fig. 10).…”

Section: Stereochemistry Of Furostanol and Spirostanol Saponinsmentioning

confidence: 99%

“…Compound 118 represents an example of pregnane with the presence of a five-membered lactone ring between C-22 and C-16. These kinds of lactone-type sapogenols and their glycosides might be biosynthetically derived from the genuine 23,26-oxygenated spirostane or furostane type [6]. The 112, 115, and 118 are reported in l " Table 3.…”

Section: Stereochemistry Of Furostanol and Spirostanol Saponinsmentioning

confidence: 99%

“…R. x microglossus is probably a hybrid between R. hypoglossum and R. hypophyllum [4]. Ruscus ponticus Woronow is a synonym of R. aculeatus L. and is widespread in Crimea and Caucasus, particularly in the forests of West and East Georgia [6]. R. ponticus is well known in this country for the preparation of ruscoponin, obtained from the underground parts of the plant [6].…”

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confidence: 99%

“…These aglycones and derived spiro-and furostanol glycosides were subsequently also isolated from other species of the genus. Moreover, a series of cholestane glycosides have been isolated only from R. colchicus, R. hypoglossum, and R. hypophyllum [21][22][23], and few examples of pregnane glycosides have been reported in R. aculeatus, R. hypoglossum, and R. ponticus [6,24]. Generally, the fresh underground parts of the plant material were extracted with methanol, and sometimes the obtained crude extract was partitioned between water and n-butanol.…”

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confidence: 99%

“…8). Furostanol compounds 50, 51, 54, 63, 80, and 97-98 were isolated from R. ponticus underground parts, and compounds 99-107 from R. ponticus leaves [6] (l " Fig. 9).…”

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confidence: 99%

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Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

2016

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The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher?s broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp. extracts. The underground parts of Ruscus plants are a source of steroidal saponins that can be classified into two structural classes: the hexacyclic spirostanol saponins and the pentacyclic furostanol saponins. The main aglycones are ruscogenin and neoruscogenin. From the pharmacological point of view, the most studied Ruscus species is undoubtedly R.?aculeatus, a very ancient phlebotherapeutic agent. Pharmacological investigations since the discovery of the vasoconstrictive and venotonic properties of ruscogenin and neoruscogenin in the underground parts of R.?aculeatus are discussed. Preparations based on Ruscus species are currently used for the treatment of chronic venous insufficiency, varicose veins, haemorrhoids, and orthostatic hypotension. Finally, analytical techniques for the quality control of R.?aculeatus extracts are reported.

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Section: Stereochemistry Of Furostanol and Spirostanol Saponinsmentioning

confidence: 99%

Section: Stereochemistry Of Furostanol and Spirostanol Saponinsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

“…8). Furostanol compounds 50, 51, 54, 63, 80, and 97-98 were isolated from R. ponticus underground parts, and compounds 99-107 from R. ponticus leaves [6] (l " Fig. 9).…”

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confidence: 99%

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Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins

2016

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Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2011–2012

Harvey

2015

Mass Spectrometry Reviews

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This review is the seventh update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2012. General aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, and fragmentation are covered in the first part of the review and applications to various structural types constitute the remainder. The main groups of compound are oligo- and poly-saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. Also discussed are medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:255-422, 2017.

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