Steroidal saponins from the genus Allium

Sobolewska, Danuta; Michalska, Klaudia; Podolak, Irma; Grabowska, Karolina

doi:10.1007/s11101-014-9381-1

Cited by 93 publications

(80 citation statements)

References 137 publications

(104 reference statements)

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“…So this compound can be further used for pharmacotherapy of various diseases. Spicatoside A from Liriope platyphylla possesses antiinflammatory activities, anti-asthma activities, anti-osteoclastogenesis activities, memory consolidation activities, neurite outgrowth activities, anti-cancer activities (Ramalingam and Kim 2016) while steroidal saponin from allium species possesses antispasmodic effect, cardioprotective activity, antifungal activity and cytotoxic activity (Sobolewska et al 2016).…”

Section: The Value Of Steroidal Saponinsmentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production.Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicinal properties, saponin glycosides are pharmacologically very important. This review is focused on important medicinal properties of steroidal saponin, its occurrence, and biosynthesis. In addition to this, some recently identified plants containing steroidal saponins in different parts were summarized. The high throughput transcriptome sequencing approach elaborates our understanding related to the secondary metabolic pathway and its regulation even in the absence of adequate genomic information of non-model plants. The aim of this review is to encapsulate the information related to applications of steroidal saponin and its biosynthetic enzymes specially P450s and UGTs that are involved at later stage modifications of saponin backbone. Lastly, we discussed the in vitro production of steroidal saponin as the plant-based production of saponin is time-consuming and yield a limited amount of saponins. A large amount of plant material has been used to increase the production of steroidal saponin by employing in vitro culture technique, which has received a lot of attention in past two decades and provides a way to conserve medicinal plants as well as to escape them for being endangered.

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Section: The Value Of Steroidal Saponinsmentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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“…Phytochemical combinations can have effects that differ from predictions based on activities of isolated components. In the incremental evolution of phytochemical‐based defenses in plants, new phytochemicals would be selected for activity in the context of a plant's preexisting phytochemical repertoire, rather than for functional value in isolation (Richards et al., 2016). Plants can therefore be expected to contain chemical components that, in addition to providing protection from diverse antagonists, act to potentiate each other's activities, and thereby economize resource allocation to defensive chemicals.…”

Section: Introductionmentioning

confidence: 99%

“…Plants can therefore be expected to contain chemical components that, in addition to providing protection from diverse antagonists, act to potentiate each other's activities, and thereby economize resource allocation to defensive chemicals. However, even in well‐established areas of chemical ecology such as plant–herbivore interactions, surprisingly few studies have explicitly examined the interacting effects of chemicals in mixtures (Richards et al., 2016), leaving much to be understood regarding the ecological functions of phytochemical mixtures and diversity.…”

Section: Introductionmentioning

confidence: 99%

“…By reducing the dose required to achieve a medicinal effect, selectively synergistic drug combinations can both reduce costs and lower the risk of patient toxicity (Greco et al., 1995). Plants, which have evolved to produce defensive mixtures under conditions of limited resources and diverse antagonists, are an intuitive place to look for synergistic chemical combinations (Richards et al., 2016). Generally speaking, synergy can occur when one compound increases the bioavailability (Smith, Roddick, & Jones, 2001), inhibits the detoxification (Berenbaum & Neal, 1985), or compromises the export of another compound (Stermitz, Lorenz, Tawara, Zenewicz, & Lewis, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Synergistic effects of floral phytochemicals against a bumble bee parasite

Palmer‐Young¹,

Sadd

Irwin

et al. 2017

Ecology and Evolution

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Floral landscapes comprise diverse phytochemical combinations. Individual phytochemicals in floral nectar and pollen can reduce infection in bees and directly inhibit trypanosome parasites. However, gut parasites of generalist pollinators, which consume nectar and pollen from many plant species, are exposed to phytochemical combinations. Interactions between phytochemicals could augment or decrease effects of single compounds on parasites. Using a matrix of 36 phytochemical treatment combinations, we assessed the combined effects of two floral phytochemicals, eugenol and thymol, against four strains of the bumblebee gut trypanosome Crithidia bombi. Eugenol and thymol had synergistic effects against C. bombi growth across seven independent experiments, showing that the phytochemical combination can disproportionately inhibit parasites. The strength of synergistic effects varied across strains and experiments. Thus, the antiparasitic effects of individual compounds will depend on both the presence of other phytochemicals and parasite strain identity. The presence of synergistic phytochemical combinations could augment the antiparasitic activity of individual compounds for pollinators in diverse floral landscapes.

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“…36) It has recently been suggested that the 22-methoxy furostanol saponins are secondary products formed from the corresponding 22-hydroxy form. 37) From the above results, trifasciatoside F could then be the artifact formed from trifasciatoside E. Compounds 6a, b-7a, b are acetyl saponins, typical unstable compounds which are extensively distributed in many species of medicinal herbs. 11,38) Due to the low activation energy of acetyl migration reaction, it may be difficult to obtain the pure acetyl saponin.…”

Section: )mentioning

confidence: 88%