Dimethyl carbonate as a modern green reagent and solvent

Abstract

The published data on dimethyl carbonate as a The published data on dimethyl carbonate as a non-toxic reagent and solvent in organic synthesis are non-toxic reagent and solvent in organic synthesis are generalized and discussed. The methods for dimethyl generalized and discussed. The methods for dimethyl carbonate production and its use as a methylating and carbonate production and its use as a methylating and methoxycarbonylating agent are considered. Special atten-methoxycarbonylating agent are considered. Special attention is paid to the eco-friendly processes that meet the tion is paid to the eco-friendly processes that meet thè Green chemistry' requirements. The bibliography includesGreen chemistry' requirements. The bibliography includes 104 references 104 references. . 2 MeOH + 1 2 O2 + CO Cu salt MeOCO2Me + H2O. F AricoÁ , P Tundo Interuniversity Consortium`Chemistry for the Environment', Via delle Industrie, Marghera 21/8,

PREPARAÇÃO DE Α-Acetiloxi-N-Cicloexilamidas ATRAVÉS DA REAÇÃO DE PASSERINI UTILIZANDO DIMETILCARBONATO COMO SOLVENTE AMBIENTALMENTE AMIGÁVEL

“…21,22 Carbonatos acíclicos como o dimetilcarbonato (DMC) e o dietilcarbonato (DEC) apresentam propriedades semelhantes às de alguns solventes convencionais, tais como o diclorometano e THF. Sua disponibilidade em grande quantidade a custo relativamente baixo, juntamente com o fato de serem biodegradáveis e de baixa toxicidade, entre outras, são características que permitem seu uso como alternativas aos solventes orgânicos voláteis tradicionais.…”

Environmentally-Benign Dimethyl Carbonate-Mediated Production of Chemicals and Biofuels from Renewable Bio-Oil

“…The oral acute toxicity (LD 50 ) of DMC for rats is 13.8 g/kg, which indicates that it is a non-toxic compound. In addition, DMC has a negligible toxic effect by inhalation [17,22]. Therefore, DMC can be safely handled compared to toxic methyl halides, dimethyl sulfate (DMS), and phosgene [18,20,22].…”

“…In addition, DMC has a negligible toxic effect by inhalation [17,22]. Therefore, DMC can be safely handled compared to toxic methyl halides, dimethyl sulfate (DMS), and phosgene [18,20,22]. The toxicological and ecotoxicological properties of DMC, DMS, and phosgene are summarized in Table 1.…”

Synthesis of Organic Carbonates with Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and ROH/AlCl3under Ambient Condition

“…Various synthetic methods of organic carbonates by the phosgenation technique using COCl 2 , the oxidative carbonylation of alcohols using CO and transition metals, the reaction of urea with alcohols, the reaction of oxiranes and CO 2 , the reaction of chloroformates, the use of metal carbonate and the organic carbonate interchange reaction have been reported. [1][2][3]9,12,13 However, the main disadvantages of these methods are the use of toxic, gaseous and/or expensive chemicals and requirement for specific additives. The alkoxycarbonylation using organic carbonate and base be also accompanied by the undesired side reaction.…”

“…Organic carbonates are generally safe noncorrosive molecules employed in numerous commercial and synthetic application [1][2][3][4] as eco-friendly useful reagents, 2,3,5-10 solvents for Li-ion battery 3,4 and electroanalytics. 3,11 The symmetric organic carbonates [(RO) 2 C=O] are useful as the solvents, whereas the unsymmetric organic carbonates [ROC(=O)OR'] are used as the key-functional group in drugs and other chemicals.…”