Dil Oynatma Hastalığı Olan Sığırlarda Serum Cu, Mn, Zn Seviyeleri ve Oksidatif Stres

Abstract

This study was aimed at determining serum copper (Cu), manganese (Mn) and zinc (Zn) levels and the occurrence of oxidative stress in cattle performing tongue-playing stereotypies. The study material comprised of 25 healthy cattle and 50 stereotypic cattle performing tongueplaying, which were of a varying age and sex composition. The stereotypic animals were observed to display non-physiological tongue movements either by raising their heads and stretching their tongue out at long or short time intervals, or by contorting, rolling or swinging their tongue and making circular tongue movements in their mouth. These animals were confirmed to perform tongue-playing stereotypies. 10 mL blood samples were taken from each animal included in the study, and the sera extracted were analysed for serum Cu, Mn, Zn, malondialdehyde (MDA), nitric oxide (NO), total oxidant status (TOS) and total antioxidant status (TAS) levels. While the serum Mn levels of the stereotypic animals were lower than those of the healthy animals (P<0.001), it was observed that the serum Cu and Zn levels of the stereotypic and healthy animals did not differ (P>0.05). While the MDA (P<0.001), NO (P<0.001) and TOS (P<0.05) levels of the stereotypic animals were found to be higher than those of the healthy animals, the TAS (P>0.05) levels did not differ between the two groups. In result, it was concluded that Mn deficiency has an important role in the aetiology of tongue-playing stereotypies, and that this behavioural disorder is associated with oxidative damage or inflammation. Oxidative stress in tongue playing disease is thought to be formed due to cellular damage or stress.

Investigations on some indicators in the blood of cattle with orosthenic activity tongue rolling

“…The analysis of some blood trace minerals (manganese, copper, and iron) in tongue-rolling cattle showed no significant differences versus controls. The findings of our study are similar to the results on the mineral profile of cattle with this oral stereotypy from different regions in Turkey [ 12 ] for manganese, copper, and iron and the results described previously [ 9 , 21 ], but only with regard to blood iron. The observed lack of differences in blood copper and manganese differed from the report of İssi et al [ 9 ], affirming that these two trace minerals were decreased in the blood of tongue-rolling cattle.…”

Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

“…MDA, hydroxy-2-nonenal (HNE), 2-propenal (acrolein), isoprostanes, oxide glutathione (GSSG), NO, total oxidant capacity (TOC), 8-hydroxy-2-deoxyguanosine (8-OHdG) are among the most studied oxidative markers clinically for this purpose. Although oxidative stress has been studied with too many diseases and syndromes, it has been reported to be effective in the development of cancer, cardiovascular disease, neural disorders, Alzheimer's disease, mild cognitive disorder, Parkinson's disease, alcohol-related liver disease, ulcerative colitis, aging and atherosclerosis, lead poisoning, liver damage due to carbon tetrachloride, aminoglycoside, reactions from drugs and toxins, such as heavy metal toxicity, chronic and degenerative diseases such as glomerulonephritis, emphysema, porphyria, bronchopulmonary dysplasia, atherosclerosis, pancreatitis, rheumatoid arthritis, aging, neurodegenerative disorders, hemolytic anemia, cardiovascular diseases, pneumonia, sepsis, mastitis, metritis, retentio secundinarum, genital tract inflammation, acidosis, tongue-playing, sepsis, mastitis, ketosis, enteritis, respiratory, joint diseases and autoimmune disorders [14,26,28,[31][32][33][34][35][36][37][38][39][40][41][42][43] .…”