This study aimed to investigate the changes in serum iron, iron binding capacity, transferrin, some oxidative stress markers, and hematological and biochemical parameters in cattle infected with foot-and-mouth disease and to reveal their importance. The animal material of the study was composed of 20 Simmental cattle between 6 and 12 months of age, which were diagnosed with foot-and-mouth disease based on the results of the clinical and laboratory examinations (patient group), and the control group was composed of 10 animals selected from a different herd, with the same age group and breed characteristics and fed with the same ration. Among the hematological parameters examined in the study, the total leukocyte count (WBC (x103/μL)) was found to be higher in the patient group with statistical significance compared to the control group (P