Enfektif Hastalıklarda Oksidan ve Antioksidan Parametrelerin Rolü: Sistematik Bir Literatür Değerlendirmesi

Abstract

The formation of reactive oxygen species is a physiological event in aerobic life. In case of infection, if the increased oxidant substances cannot be cleaned sufficiently by antioxidants, oxidative stress occurs. As a result, a number of pathological problems occur by damaging DNA, protein, carbohydrate and lipids. In biological systems, the balance between oxidants and antioxidants is important. In oxidative stress situations where the balance cannot be achieved sufficiently, support can be provided with the use of exogenous antioxidants. However, the molecular structure, route of administration and concentrations of these exogenous antioxidants are important. Otherwise, they may show a pro-oxidative effect. The present rewiev study makes a general overview of oxidative-nitrosative stress markers commonly used in infective clinical studies, antioxidant enzymes and parameters and antioxidant supplements.

Evaluation of iron, iron binding capacity, transferrin, some oxidative stress markers and hematological parameters in foot and mouth disease in cattle

“…The level of GSH decreases during oxidative stress (Yurdakul and Saritas, 2013). Studies on foot and mouth disease have reported that GSH levels decreased in the patient groups (Uzlu et al, 2016, Cenesiz 2020). In the current study, we think that the GSH level decreased as a result of pathological changes in tissues and organs due to cellular damage caused by the increase in oxidants.…”

“…GSH is one of the nonenzymatic antioxidant defense systems. GSH is frequently measured to determine oxidative stress in the blood (Cenesiz, 2020). The level of GSH decreases during oxidative stress (Yurdakul and Saritas, 2013).…”

Determination of isoprostane 8‐iso‐PGF2α and prostaglandin GF2α in plasma and intestine of specific-pathogen-free chickens challenged with Eimeria maxima

“…Since the cellular components that suffer immediate damage are the lipids and proteins of the cell membrane and mitochondrial membrane by lipid peroxidation, the whole-cell physiology is then compromised. One of the cellular mechanisms to revert oxidative stress is the production of several heat shock proteins that repair damage proteins and regulate apoptosis 35,36,37 . A noteworthy result observed in this study was the signi cant increase (P<0.01) in isoprostane 8-iso-PGF2α in the jejunum of chickens challenged with E. maxima at 7-(P=0.0000252) and 9-days (P=0.000000717) post-challenge compared to the non-challenge control chickens.…”

Thiols: Role in Oxidative Stress-Related Disorders

“…Respiratory burst, also known as "oxidative burst", is the event of a rapid release of ROS such as O 2 −• and hydrogen peroxide (H 2 O 2 ) from different cell types. Generally, these chemicals are produced by immune system cells such as neutrophils and macrophages as a result of infection of the organism by bacteria and fungi [25,26]. In phagocytes, the respiratory burst that occurs to break down bacteria plays an important role in the immune system.…”