Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

Wan, Fan; Han, Hui; Zhong, Ruqing; Wang, Mengyu; Tang, Shouwei; Zhang, Shunfen; Hou, Fujiang; Yi, Bao; Zhang, Hongfu

doi:10.1039/d1fo01422f

Cited by 74 publications

(59 citation statements)

References 65 publications

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“…Importantly, increasing evidence suggests that the gut microbiota and its metabolites are involved in the development and progression of several types of cancer by influencing inflammation, DNA damage, and apoptosis [63]. Several studies have identified that the decrease of several potentially beneficial bacterial species (including Lactobacillus, Bifidobacterium, Oscillibacter, Ruminiclostridium 9, and Dubosiella), and the increase of some adverse bacterial species (including Enterococcus, Enterotoxigenic bacteroides fragilis, Streptococcus, Helicobacter, Fusobacterium nucleatum, Escherichia-Shigella, Klebsiella and Akkermansia), which are closely correlated with an increased risk of CRC [11,13,17,[64][65][66]. The data from our study showed that AOM/DSS stimulus inevitably disturbed the balance of intestinal microbiota, as shown by a dramatic decrease in the abundance of dominant microbiota Lactobacillus and Dubosiella, and an increase in the abundance of harmful bacteria Bacteroides, Escherichia-Shigella, and Akkermansia.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, intestinal microbiota has been divided into three categories based on their effects in the intestinal tract, including physiologic bacteria, conditional pathogens, and pathogens [12]. Changes of the enteral and external environments can cause a diminish in the proportion of intestinal-dominant microbiota, while conferring a survival advantage upon pathogens or conditional pathogens [13,14]. Available evidence has demonstrated that the immune system acts as a crucial link in the interactions between gut microbiota and CRC.…”

Section: Introductionmentioning

confidence: 99%

“…A dysbiotic microbial community with pro-carcinogenic features is considered to be a major contributor to colorectal carcinogenesis by influencing the inflammatory signals [15][16][17]. In this scenario, several potentially beneficial (Lactobacillus, Bifidobacterium, Faecalibacterium prausnitzii, Roseburia, and Enterococcus) and harmful (Enterococcus, Enterotoxigenic bacteroides fragilis, Streptococcus, and Helicobacter) bacterial species have been identified, and demonstrated to be important in CRC progression [11][12][13]. Therefore, the pathogenesis of CRC is closely correlated with the intestinal microbiota, and gut microbiota dysbiosis plays a significant role in the manifestation of CRC.…”

Section: Introductionmentioning

confidence: 99%

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Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

et al. 2022

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Inflammatory activation and intestinal flora imbalance play an essential role in the development and progression of colorectal cancer (CRC). Berberine (BBR) has attracted great attention in recent years due to its heath-related benefits in inflammatory disorders and tumors, but the intricate mechanisms have not been fully elucidated. In this study, the effects and the mechanism of BBR on colon cancer were investigated in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated carcinogenesis mice model. Our results showed that pre-administration of BBR showed a decrease in weight loss, disease activity index (DAI) score, and the number of colon tumors in mice, compared with the model group. The evidence from pathological examination indicated that the malignancy of intestinal tumors was ameliorated after pre-administration of BBR. Additionally, pre-administration with BBR suppressed the expression of pro-inflammatory factors (interleukin (IL)-6, IL-1β, cyclooxygenase (COX)-2 and tumor necrosis factor (TNF)-α) and the cell-proliferation marker Ki67, while expression of the tight junction proteins (ZO-1 and occludin) were increased in colon tissue. Moreover, the levels of critical pathway proteins involved in the inflammatory process (p-STAT3 and p-JNK) and cell cycle regulation molecules (β-catenin, c-Myc and CylinD1) exhibited lower expression levels. Besides, 16S rRNA sequence analysis indicated that pre-administration of BBR increased the ratio of Firmicutes/Bacteroidetes (F:M) and the relative abundance of potentially beneficial bacteria, while the abundance of cancer-related bacteria was decreased. Gavage with Lactobacillus rhamnosus can improve the anti-tumor effect of BBR. Overall, pre-administration of BBR exerts preventive effects in colon carcinogenesis, and the mechanisms underlying these effects are correlated with the inhibition of inflammation and tumor proliferation and the maintenance of intestinal homeostasis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

et al. 2022

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“…In addition, Bifidobacterium, Dubosiella, Allobaculum, Atopobiaceae, Akkermansia and Faecalibaculum were enriched to varying degrees in the three dietary intervention groups. According to previous studies, they also have an explicit or potential association with gut microecological health [52][53][54][55]. This mainly includes the function of resisting LPS, enhancing intestinal mucosal function and producing SCFAs.…”

Section: Discussionmentioning

confidence: 98%

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

Zhao¹,

Wang²,

Cheng³

et al. 2022

Nutrients

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The disturbance of intestinal microorganisms and the exacerbation of type 2 diabetes (T2D) are mutually influenced. In this study, the effect of exopolysaccharides (EPS) from Lactobacillus plantarum JY039 on the adhesion of Lactobacillus paracasei JY062 was investigated, as well as their preventive efficacy against T2D. The results showed that the EPS isolated from L. plantarum JY039 effectively improved the adhesion rate of L. paracasei JY062 to Caco-2 cells (1.8 times) and promoted the proliferation of L. paracasei JY062. In the mice experiment, EPS, L. paracasei JY062 and their complex altered the structure of the intestinal microbiota, which elevated the proportion of Bifidobacterium, Faecalibaculum, while inversely decreasing the proportion of Firmicutes, Muribaculaceae, Lachnospiraceae and other bacteria involved in energy metabolism (p < 0.01; p < 0.05); enhanced the intestinal barrier function; promoted secretion of the gut hormone peptide YY (PYY) and glucagon-like peptide-1 (GLP-1); and reduced inflammation by balancing pro-inflammatory factors IL-6, TNF-α and anti-inflammatory factor IL-10 (p < 0.01; p < 0.05). These results illustrate that EPS and L. paracasei JY062 have the synbiotic potential to prevent and alleviate T2D.

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“…Many studies reported that rutin, apigenin 7-O-β-D-glucose, and rhoifolin, had significant antioxidant effects on inhibiting oxidative stress and anti-inflammatory effects via suppressing the expressions of IL-1β, IL-6, and TNF-α [ 23 , 24 , 25 ]. In addition, quercetin and kaempferol derivatives exhibited inhibitory effects on intestinal inflammation and protective effects on the intestinal barrier [ 26 , 27 , 28 ]. Thus, the relative higher contents of quercetin and kaempferol derivatives allowed the potential application value in the treatment of UC.…”

Section: Discussionmentioning

confidence: 99%

Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins

et al. 2022

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The aim of the research was to determine the protective effect and mechanism of Pteris wallichiana J. Agardh extract (PWE) on DSS-induced ulcerative colitis (UC) in mice. In this research, PWE is rich in flavonoids and diterpenoids by UPLC-MS/MS analysis. In LPS-induced RAW264.7 cells, PWE reduced the productions of inflammatory factors (i.e., NO, TNF-α, IL-6, and IL-1β). In DSS-induced UC in mice, PWE improved disease activity index (DAI) score, attenuated oxidative stress by decreasing MPO and MDA activities and activating GSH and SOD levels, and inhibited TNF-α, IL-6, and IL-1β expressions in the colonic tissues. PWE also improved the intestinal barrier by upregulating the expressions of tight junction proteins, including occludin and ZO-1. Moreover, PWE extract alleviated intestinal inflammation by suppressing the TLR4/MyD88/NF-κB signaling pathway. Conclusion: PWE can alleviate DSS-induced UC in mice by increasing the expressions of intestinal tight junction proteins and inhibiting the TLR4/NF-κB inflammatory pathway.

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Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

Abstract: The purpose of the current study was to investigate the effect of dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ supplementation (3...

Cited by 74 publications

References 65 publications

Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins

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