Diffusion-Weighted Magnetic Resonance Imaging for Diagnosing Malignant Pulmonary Nodules/Masses: Comparison with Positron Emission Tomography

Abstract

DWI may be able to be used in place of FDG-PET to distinguish malignant from benign pulmonary nodules/masses with fewer false-positive results compared with FDG-PET.

Relationships between EGFR Mutation Status of Lung Cancer and Preoperative Factors - Are they Predictive?

“…Adenocarcinomas with a bronchiolo-alveolar carcinoma (BAC) component are known to be significantly correlated with EGFR mutations (Lynch et al, 2004;Pao et al, 2004;Tam et al, 2006, Sun et al, 2012. The BAC component is likely to have weak accumulation of 18F-FDG (18-fluoro-2-deoxyglucose) in positron emission tomography-computed tomography(PET-CT) ( Mori et al, 2008) and have less tissue cellularity, which is characterized by diffusionweighted magnetic resonance imaging (DWI) (Usuda et al, 2013). PET-CT with 18F-FDG is widely accepted as an imaging modality of choice in tumor staging because of its good sensitivity (Dwamena et al, 1999;Toloza et al, 2003).…”

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

“…Mori et al (50) prospectively performed both 18 F-FDG PET and DWI on 104 patients with 140 pulmonary nodules or masses (106 malignant lesions and 34 benign lesions) within a 2-wk interval. On 18 F-FDG PET, a standardized uptake value (SUV) contrast ratio between each lesion and the contralateral lung (SUV CR ) was measured, whereas on DWI, the ADC min of each lesion was measured, using region-of-interest analysis.…”

“…A total of 110 patients who had 124 pulmonary nodules smaller than 3 cm (96 NSCLCs and 28 benign nodules) and had undergone both 18 F-FDG PET and DWI within a 2-wk interval were retrospectively assessed. ADC min and SUV CR measurements were done and analyzed as described previously (50). In addition, the ADC min and the SUV CR were compared between pathologic stage IA and stage IB or more advanced stages; between tumors with and without lymphatic, vascular, or pleural involvement; and between well-differentiated and moderately or poorly differentiated adenocarcinomas.…”

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

“…Diffusion of water molecules in malignant tumors is usually restricted compared to that in normal tissue, resulting in a decreased apparent diffusion coefficient (ADC) value (Szafer et al, 1995;Takahara et al, 2004). Some recent studies comparing DWI with FDG-PET have shown that DWI at 1.5 T is comparable with FDG-PET for detecting malignant lesions (Komori et al, 2007;Nomori et al, 2008;Mori et al, 2008), and an meta-analysis has shown that DWI can be used to differentiate malignant from benign pulmonary lesions . It is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary nodules and masses.…”