Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

“…6) For pulmonary nodules and masses, the sensitivity (80.0%) of DWI was significantly better than that (70.0%) of FDG-PET/CT. 19) The specificity (65.5%) of DWI was as same as that (65.5%) of FDG-PET/CT, and the accuracy (77.8%) of DWI was not significantly better than that (69.3%) of FDG-PET/CT. 19) Because there was no prospective randomized controlled trial between DWI and FDG-PET/CT for pulmonary nodules and masses, we do not conclude which diagnostic capability is higher, but can speculate that the diagnostic capability of DWI is compatible to that of FDG-PET/CT for pulmonary nodules and masses.…”

“…Second, in DWI, mucinous carcinomas were usually hypointense and showed higher ADC values, which could be misjudged as benign lesions in DWI. 19) Mucinous carcinomas had lower DWI signal intensity and higher ADC values than tubular adenocarcinoma in the ano-rectal region because mucinous carcinomas had lower cellularity than tubular adenocarcinomas. 24) There were two articles which compared diagnostic capability of DWI with that of FDG-PET/CT for pulmonary nodules and masses.…”

“…24) There were two articles which compared diagnostic capability of DWI with that of FDG-PET/CT for pulmonary nodules and masses. 6,19) The sensitivity and the accuracy of DWI were significantly better than those of FDG-PET/CT for pulmonary nodules and masses. 6) For pulmonary nodules and masses, the sensitivity (80.0%) of DWI was significantly better than that (70.0%) of FDG-PET/CT.…”

“…ADC value of adenocarcinoma with bronchioloalveolar carcinoma features was almost same to that of solid lung cancer, but SUVmax of adenocarcinoma with bronchioloalveolar carcinoma features was similar to that of benign pulmonary lesions, which is one of the reasons that some lung cancers are likely to be false negative in FDG-PET/CT. 19) On the other hand, DWI has two limitations. First, one of the pulmonary lesions which showed restricted diffusion and lower ADC values in DWI is pulmonary abscess with histopathological necrosis.…”

Diagnostic Significance of Apparent Diffusion Coefficient Values with Diffusion Weighted MRI in Breast Cancer: a Meta-Analysis

“…Several investigation regarding the ADC measurement with DWI have been widely performed, and taking the Asian Pacific Journal of Cancer Prevention for example, published articles mainly concentrated on the diagnosis and differential diagnosis of human tumors. For instance, evidence indicated that DWI might be useful for detection of recurrence and metastasis of lung cancer, or ADC measurements may be utilized to improve the differential diagnosis accuracy of benign and malignant focal liver lesions, DWI has higher potential than other imaging methods like positron emission tomography in assessing pulmonary nodules and masses, yet no more other publishes focused on the differential diagnosis of BC which may restrict a wide references and applications of DWI in the differential diagnosis of human tumors (Han et al, 2014;Usuda et al, 2014a;2014b). The most important conclusion of the current study is that the ADC values of lymph nodes with metastasis was apparently lower compared to those of benign or normal lymph nodes, indicating that DWI might be an useful method in the characterization and diagnosis of malignant LNM in BC patients by means of measuring the ADC values.…”