Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers in Infarcted Myocardium

Sosnovik, David E.; Wang, Ruopeng; Dai, Guangping; Wang, Teresa; Aikawa, Elena; Novikov, Mikhael; Rosenzweig, Anthony; Gilbert, Richard J.; Wedeen, Van J.

doi:10.1161/circimaging.108.815050

Cited by 103 publications

(126 citation statements)

References 30 publications

(51 reference statements)

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“…Examples include high-resolution DTI in mouse hearts. 17 and diffusion spectrum imaging in infarcted rat hearts 20 The design of a phantom needs to balance mimicking biological structure, reproducibility in manufacture, and amenability to characterization and validation. On the one hand, it could be argued that the phantom should recapitulate the branching syncytium and discrete sheet arrangement found in the myocardium.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic phantom for cardiac diffusion MRI

Teh

Zhou

Cristinacce

et al. 2016

Magnetic Resonance Imaging

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Purpose: Diffusion magnetic resonance imaging (MRI) is increasingly used to characterize cardiac tissue microstructure, necessitating the use of physiologically relevant phantoms for methods development. Existing phantoms are generally simplistic and mostly simulate diffusion in the brain. Thus, there is a need for phantoms mimicking diffusion in cardiac tissue. Materials and Methods: A biomimetic phantom composed of hollow microfibers generated using co-electrospinning was developed to mimic myocardial diffusion properties and fiber and sheet orientations. Diffusion tensor imaging was carried out at monthly intervals over 4 months at 9.4T. 3D fiber tracking was performed using the phantom and compared with fiber tracking in an ex vivo rat heart. Results: The mean apparent diffusion coefficient and fractional anisotropy of the phantom remained stable over the 4-month period, with mean values of 7.53 6 0.16 3 10 -4 mm 2 /s and 0.388 6 0.007, respectively. Fiber tracking of the 1st and 3rd eigenvectors generated analogous results to the fiber and sheet-normal direction respectively, found in the left ventricular myocardium. Conclusion: A biomimetic phantom simulating diffusion in the heart was designed and built. This could aid development and validation of novel diffusion MRI methods for investigating cardiac microstructure, decrease the number of animals and patients needed for methods development, and improve quality control in longitudinal and multicenter cardiac diffusion MRI studies.

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Section: Discussionmentioning

confidence: 99%

Biomimetic phantom for cardiac diffusion MRI

Teh

Zhou

Cristinacce

et al. 2016

Magnetic Resonance Imaging

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“…This method allows imaging of the architecture of the organization of myocardial fibers with exceptional resolution (13). Using this technique, Sosnovik et al revealed the presence of meshlike networks of orthogonal myofibers within the infarcted rat myocardium (14).…”

Section: Strengths and Weaknesses Of Mr Versus Ct As An Adjunct To Petmentioning

confidence: 99%

Hybrid PET/MR Imaging of the Heart: Potential, Initial Experiences, and Future Prospects

et al. 2013

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Learning Objectives: On successful completion of this activity, participants should be able to describe (1) advantages and shortcomings of hybrid PET/MR scanners with respect to cardiovascular applications (e.g. myocardial perfusion imaging and viability imaging), (2) additional value of the MR component in cardiac imaging, and (3) technical challenges and workflow considerations regarding hybrid PET/MR scanners in the field of cardiology (e.g. attenuation correction and cardiac/respiratory/patient motion).Financial Disclosure: Dr. Schwaiger is an investigator, meeting participant, and lecturer for Siemens Medical. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, participants can access this activity through the SNMMI Web site (http:// www.snmmi.org/ce_online) through March 2016.PET/CT and other combined scanners have in the past decade rapidly emerged as important research tools and are proving to be invaluable for improved diagnostics in routine nuclear medicine. The design of hybrid PET/MR scanners presented a formidable technical challenge, and only recently were these instruments introduced to the market. Initial expectations of the performance of these scanners have been high, notably because of the potential for superior tissue contrast inherent in the MR modality, as well as the potential for multiparametric functional imaging in conjunction with PET. However, the additional value and potential clinical role that these new systems might bring to the cardiac field have yet to be documented. This review presents a comparative summary of the existing applications for PET and MR in the field of cardiology and suggests potential cardiac applications exploiting unique properties of the newly introduced combined instrumentation. The diverse range of imaging modalities for cardiology includes echocardiography, CT, MR imaging, SPECT, and PET, each of which offers distinct properties and advantages. The demand for combined PET/CT instrumentation in clinical nuclear medicine has grown remarkably, because of the notable advantages presented by hybrid imaging with respect to anatomic localization of lesions. Although these advantages were initially driven by the demands of oncology imaging, the resultant broader availability of PET/CT has provided the opportunity to use these scanners for indications beyond oncology, such as in the field of cardiac imaging (1). Furthermore, CT images are necessary for rapid attenuation correction, which is of particular importance for quantification in myocardial perfusion imaging. Through the use of suitable CT components a...

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“…137 Recently, myocyte fiber tracking with diffusion tensor CMR has shown fiber remodeling in the epicardial viable rim of infarctions with nodes of orthogonal myofiber intersection or contact, which are potential sources of arrhythmia in this region. 138 In cardiomyopathy, the presence of LGE has also been linked to outcomes. In DCM, midwall LGE predicted sudden cardiac death and ventricular tachycardia and was superior to ejection fraction, 71 findings that have now been replicated.…”

Section: Electrophysiologymentioning

confidence: 99%