Cardiovascular Magnetic Resonance

Pennell, Dudley J.

doi:10.1161/circulationaha.108.811547

Cited by 260 publications

(162 citation statements)

References 180 publications

(156 reference statements)

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“…Specifically, LV epicardial/endocardial borders are better delineated, and all hypertrophied segments are visualized without any risk of obliquity. [18][19][20][21] It is for the above reasons that we consider the CMR measurement to be the reference standard for the purpose of this study.…”

Section: Discussionmentioning

confidence: 99%

Discrepant Measurements of Maximal Left Ventricular Wall Thickness Between Cardiac Magnetic Resonance Imaging and Echocardiography in Patients With Hypertrophic Cardiomyopathy

Hindieh

Weissler‐Snir

Hammer

et al. 2017

Circ: Cardiovascular Imaging

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Background-We sought to compare maximal left ventricular (LV) wall thickness (WT) measurements as obtained by routine clinical practice between echocardiography and cardiac magnetic resonance (CMR) and document causes of discrepancy. Methods and Results-One-hundred and ninety-five patients with hypertrophic cardiomyopathy (median age, 52.8±15.1 years) who underwent echocardiography and CMR imaging within 6 months (median, 41 days; interquartile range, 16-97 days) were included. LVWT was assessed in parasternal long and short axis by 2-dimensional echocardiography and in short axis by CMR. By Bland-Altman plot, mean maximal LVWT difference between echocardiography and CMR was 0.5 mm (95% confidence interval, −6.9, 7.8) with equal distribution of discrepancy along the full range of LVWT. Ninety-seven patients (49.7%) were identified to have intermodal measurement discrepancies ≥10%. In 7 patients (7.2%), reported measurement by CMR was inaccurate because of interpretation error. In 90 patients (92.8%), echocardiography underestimated (n=32; 33.0%) or overestimated (n=58; 59.8%) maximal LVWT. Underestimation was because of focal LV hypertrophy (n=10; 10.3%) or poor acoustic windows (n=22; 22.7%) while overestimation resulted from inclusion of right ventricular myocardium (n=37; 38.1%), LV trabeculations (n=5; 5.2%), papillary muscle (n=3; 3.1%), and apical-septal bundle (n=1; 1.0%), as well as imaging plane obliquity (n=7; 12.5%). In 31 (15.9%) patients, measurement discrepancy occurred at diagnostic or prognostic cut-offs. Conclusions-Although maximal LVWT by echocardiography in general measured similar to CMR, discordance because of limitations in echocardiography technique was present in a significant subset of patients. As measurement of LVWT impacts diagnosis and sudden death management, CMR should be considered as part of routine evaluation of all patients with hypertrophic cardiomyopathy. (Circ Cardiovasc Imaging. 2017;10:e006309.

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Section: Discussionmentioning

confidence: 99%

Discrepant Measurements of Maximal Left Ventricular Wall Thickness Between Cardiac Magnetic Resonance Imaging and Echocardiography in Patients With Hypertrophic Cardiomyopathy

Hindieh

Weissler‐Snir

Hammer

et al. 2017

Circ: Cardiovascular Imaging

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“…The vectors of these spins are then altered using radiofrequency pulses, and the processes by which the spins return to their original alignment provide signal that can be interpreted to provide information about the tissue in which the protons are located. Magnetic resonance imaging does not utilize ionizing radiation, has excellent spatial resolution, and can provide detailed information regarding soft tissue characteristics [5]. CMR is the reference standard for assessing left ventricular systolic function and volumes and plays an important role in the detection and monitoring of cardiotoxicity from chemotherapy and radiation therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Detection of Cardiac Toxicity Due to Cancer Treatment: Role of Cardiac MRI

Meyersohn

Pursnani

Neilan

2015

Curr Treat Options Cardio Med

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Common cancer treatments including anthracycline-based chemotherapy, tyrosine kinase inhibitors, and thoracic radiation therapy can result in short- and long-term cardiovascular complications with a significant impact on morbidity and mortality. Anthracycline-based chemotherapy and tyrosine kinase inhibitors are associated with left ventricular systolic dysfunction and heart failure. Radiation therapy is associated with restrictive cardiomyopathy, coronary artery disease, as well as pericardial and valvular disease. The current standard surveillance of oncology patients for cardiotoxicity involves echocardiography, radionuclide cardiac blood pool imaging, and cardiac magnetic resonance (CMR) imaging. CMR can be used to evaluate ventricular structure and function, which is important for management decisions to prevent further cardiac injury. In patients for whom standard surveillance imaging demonstrates a drop in systolic function with or without symptoms, the use of CMR is an appropriate next step for further evaluation due to the accuracy and reproducibility of measurements of function and volumes combined with the additive information provided by tissue characterization through imaging of myocardial edema and myocardial fibrosis, although the clinical applications of these latter are as yet unclear. Overall, detection of early cardiotoxicity is important since therapeutic response is improved with prompt initiation of medical treatment.

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“…MRI has been proven of clinical value for assessment of cardiac function and structure (7,8,26). The unique challenges posed by cardiac imaging such as physiological motion and position of the heart can decrease image quality, especially SNR in low filed MRI (8,27).…”

Section: Discussionmentioning

confidence: 99%

“…Compared to 1.5 T MRI, 3.0 T MRI increases the signal-tonoise ratio (SNR) for the myocardium and blood, allowing accurate assessment of ventricular and atrial dysfunction, visualization and quantification of the morphology of the mitral valve (7,8). These advantages can overcome the limitations of conventional echocardiography, such as the low spatial resolution and significant observer variability, which can affect the measurements' reproducibility and credibility (9).…”

Section: Introductionmentioning

confidence: 99%

Assessing Mitral Regurgitation in Patients with Dilated Cardiomyopathy Using 3.0T Cardiac Magnetic Resonance Imaging: Correlation with Morphological and Functional Abnormalities

et al. 2016

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Background: Mitral regurgitation frequently accompanies dilated cardiomyopathy (DCM), which is associated with poor prognosis. Objectives: To evaluate morphological and functional abnormalities in DCM patients and correlate these features with the severity of coexistent mitral regurgitation using 3.0 T magnetic resonance imaging (MRI). Patients and Methods: Forty-one patients with DCM and 26 healthy control subjects underwent MRI and echocardiography examinations. The maximum and minimum mitral annulus areas (MAA), diameters of left ventricle and atrium, end-diastolic and systolic volumes, and ejection fraction were assessed with MRI and were indexed to body surface area. Mitral regurgitation severity grading was estimated by echocardiography. Results: Of the 41 patients with DCM, echocardiography examination revealed 11 patients (27%) without mitral regurgitation and 12 (29%) with mild, 11 (27%) with moderate, and seven (17%) with severe mitral regurgitation. All of the morphological and functional parameters of left ventricle, atrium and mitral valve in DCM patients were greater than those in healthy subjects (all P < 0.05), except for ejection fraction. The indexed end-systolic diameters of left ventricle (LVESD) and atrium (LAESD) and indexed minimum MAA might have the capability to distinguish no/mild mitral regurgitation patients from moderate/severe patients (areas under the receiver operating characteristic curve [AUC] = 0.876, 0.816, and 0.773, respectively; all P < 0.05). Using a combination of indexed LAESD, LVESD and minimum MAA, the specificity increased to 91.3%. Conclusion: Mitral regurgitation in DCM patients is associated with morphological and functional abnormalities of left heart and mitral valve annulus. The indexed LVESD, LAESD, and minimum MAA values can assist in predicting the severity of mitral regurgitation with a high sensitivity and specificity.

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Cardiovascular Magnetic Resonance

Cited by 260 publications

References 180 publications

Discrepant Measurements of Maximal Left Ventricular Wall Thickness Between Cardiac Magnetic Resonance Imaging and Echocardiography in Patients With Hypertrophic Cardiomyopathy

Discrepant Measurements of Maximal Left Ventricular Wall Thickness Between Cardiac Magnetic Resonance Imaging and Echocardiography in Patients With Hypertrophic Cardiomyopathy

Detection of Cardiac Toxicity Due to Cancer Treatment: Role of Cardiac MRI

Assessing Mitral Regurgitation in Patients with Dilated Cardiomyopathy Using 3.0T Cardiac Magnetic Resonance Imaging: Correlation with Morphological and Functional Abnormalities

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