Diffusion kurtosis imaging study of prostate cancer: Preliminary findings

Abstract

DKI may contribute to the imaging diagnosis of prostate cancer, especially in the differential diagnosis of prostate cancer and BPH.

Assessment of chemotherapy response in non-Hodgkin lymphoma involving the neck utilizing diffusion kurtosis imaging: a preliminary study

“…It is considered that this new imaging analysis method is more sensitive to reflect the complexity of tissue microstructure than the conventional monoexponential model (16,17). DKI has been demonstrated to be of great value when estimating the grading of many diseases, such as brain disorders (18,19), head and neck cancers (20), bladder cancers (21), prostate cancer (22), hepatocellular carcinoma (23), and breast lesions (24). Considering the microstructure of lymphoma, it is proposed that the non-Gaussian model could be a better predictor for the chemotherapy response in lesions.…”

Histogram analysis of diffusion kurtosis magnetic resonance imaging in differentiation of pathologic Gleason grade of prostate cancer

“…A very important part of these differences is the choice of optimal number, range, and position of b values. For previous studies of DK imaging in the prostate, the b value spectrum was mostly 0-2,000 s/mm 2 , except in the study by Tamura et al (0-1,500 s/mm 2 ) [22][23][24]34]. It is suggested from the study about the optimization of b value distribution for different mathematical models of prostate that, the parameters of the DK model were best estimated using 5 to 7 b values in the ranges of 300 to 2,000 s/mm 2 , in addition to low b value [35].…”

“…However, the study was limited by the lack of a precise histological reference standard to define regions of cancer. Suo et al [23] and Tamura et al [24] also conducted a similar study about PCa, but the patient population size was relatively small. Moreover, the existing studies are limited by the performance with a region of interest (ROI)-based measurement.…”

“…Thus, we concluded that the DK model with entire-tumor histogram analysis is a more promising way for determining pathologic Gleason grade of PCa preoperatively. Application of the DK model for quantitation of DW imaging in the prostate has been gaining increasing interest in recent years [20,21,23,24]. Although still with many dissents, the DK model seemed to be the preferred model considering the model fit and repeatability with b values up to 2,000 s/mm 2 [32,33].…”

Recent Developments in Fast Kurtosis Imaging

“…Consequently, interest in DKI for body imaging is growing [29] with demonstrated applications in imaging of liver [30,31], kidney [32,33], and prostate [34][35][36].…”