Diffusible factors from rat arcuate nucleus and Broca's diagonal band nucleus increase size and neurite outgrowth, respectively, of cultured melanin-concentrating hormone containing neurons

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

“…Further understanding of the role of MCH in food intake may be reached by investigating which, if any, NPY receptor(s) is expressed in MCH cells. Furthermore, it has been shown that (unidentified) factors from the arcuate may provide trophic signals to MCH neurons (Compagnone et al, 1993), indicating a potential long-term role for NPY in the LHA. Lastly, the demonstration that periventricular MCH-ir cells differ from the LHA cells morphologically and with regard to NPY innervation is interesting in light of the report by Presse and Nahon (1993) that MCH cells in different hypothalamic areas respond differently to osmotic manipulations.…”