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The pancreatic islets contain four types of parenchymal cells, three of them are granulated (al-or D-, a*-or A-, and p-cells) and one is agranular and probably identical to the y-cell of Bowie (1924). On the basis of histochemical and autoradiographic studies (Falkmer et al.

The original metal-salt technique of Gomori (1948a) employing p-chloranilidophosphonic acid as a substrate for the demonstration of the activity of phosphoamidase has been used with varying success by a number of investigators for light microscopy. Cyclophosphamide (endoxan) which is a cytotoxic drug known to activate phosphoamidase and other lysosomal enzymes in neoplasm (Grillo, 1971) is proposed as another substrate for the enzyme for both light and electron microscopy.

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