Diffuse type testicular seminoma in a stallion

Farjanikish, Ghasem; Sayari, Mohammad; Raisi, Abbas; Shirian, Sadegh

doi:10.1007/s00580-016-2316-z

Cited by 4 publications

(11 citation statements)

References 16 publications

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“…Seminoma has been described in species including dogs, horses, humans and rams with a distinct macroscopic presentation in each case [1,2,5,8]. The present findings are the second ever seminoma reported in goats, and particularly this case presented liver metastasis, showing the pathologic potential of this neoplasia for this species, and it differed from those reported previously [6] who described ulcerative lesions in, and adhesion of the skin covering the testis.…”

Section: Discussioncontrasting

confidence: 63%

“…Seminomas are germ cell tumors mainly originating from spermatogonia in the seminiferous tubules and are characterized by spherical or polyhedral neoplastic cells [4,8]. Seminoma has been described in several domestic animal species [1,2,8] and in humans [5]. Nevertheless, in goats, only a single case was reported previously [6].…”

Section: Introductionmentioning

confidence: 99%

“…Seminomas tumors may be single or multiple, bilateral or unilateral, cystic or non-cystic, and diffuse or intratubular. They are not usually metastatic and rarely trigger paraneoplastic syndrome [2]. Cryptorchidism confers a predisposition to development of seminoma, and the neoplasia most often occurs in older animals [4].…”

Section: Introductionmentioning

confidence: 99%

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Metastatic Seminoma in a Male Alpine Goat: Clinical and Histopathological Approach

Cosentino

Balaro

Carvalho

et al. 2019

Acta Scientiae. Vet.

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Background: Seminomas are germ cell tumors mainly originating from spermatogonia in the seminiferous tubules and has been described in several domestic animal species, even though has rarely been described in goats. Moreover, seminomas tumors are not usually metastatic and rarely trigger paraneoplastic syndrome. In this sense, this is a case report of a 12-year-old male Alpine goat, suspected of testicular neoplasm based on clinical examination and ultrasound imaging, diagnosed as a seminoma with metastasis in liver by histopathology upon necropsy. Case: A 12-year-old male Alpine goat presented a 10 month history of progressive weight loss, prostration, and scrotal sac enlargement. The major clinical findings were pale conjunctival mucus, bilateral nasal catarrhal secretion, obstructive dyspnea, an increased abdominal component, crackling at trachea auscultation, silence upon lung auscultation of the ventral area and wheezing upon auscultation of the dorsal area, and enlargement of the left testicle with contralateral atrophy. At the Ultrasonography scan, the enlarged left testicle presented architecture loss, as well as circumscribed masses differing in echogenicity and echotexture with scattered small hyperechoic nodules. The shrunken right testicle showed acoustic shading across the surface suggestive of calcification. Due to the poor prognosis and regard for animal welfare, the goat was euthanized. The main necropsy findings on testicles were: enlarged left testicle with white parenchyma on the dorsal side as well as diffuse yellow elliptical lesions of 0.5-2.5 cm on the surface in association with two circumscribed areas at the cranial and caudal poles, firm upon cutting. The right testicle was half the typical size, slightly pale, firm at cutting of the tunica albuginea, and presented dark parenchyma with abundant calcification dots suggestive of microlithiasis. The histological findings included diffuse tumoral stroma of the left testicle composed of large, polyhedral, discretely demarcated circular cells exhibiting a large nucleus varying in size with little cytoplasm and a high mitotic rate. The right testicle exhibited areas of necrosis and fibrosis of the testicular parenchyma, contiguous with the area of degeneration and normal parenchyma, caseous necrosis, and focal calcification. The liver presented some foci of the same cellular pattern of the seminoma, as described in the parenchyma. The findings summarized at necropsy and histopathological evaluation were seminoma in the left testicle, with metastasis to the liver; degeneration and necrosis of the right testicle with abscess and calcification. Discussion: Seminoma has been described in several species, even though rarely in goats. This report was the second ever seminoma reported in caprine species, and particularly this case presented liver metastasis, showing the pathologic potential of this neoplasia for this species, and it differed from first reported which described ulcerative lesions in, and adhesion of the skin covering the testis. Regard...

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Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Metastatic Seminoma in a Male Alpine Goat: Clinical and Histopathological Approach

Cosentino

Balaro

Carvalho

et al. 2019

Acta Scientiae. Vet.

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“…Seminomas are the most frequently reported testicular tumors in horses and arise from spermatogenic cells that usually occur unilaterally (more frequently right‐sided) . In advanced stages, as in this case, the entire testicular tissue can be replaced and represents the diffuse type of seminoma . Cryptorchidism seems to be a predisposing factor .…”

Section: Discussionmentioning

confidence: 76%

“…2 In advanced stages, as in this case, the entire testicular tissue can be replaced and represents the diffuse type of seminoma. 3 Cryptorchidism seems to be a predisposing factor. 1 Frequent associations with interstitial or Sertoli cell tumors are described for seminoma in the dog but has rarely been observed in horses.…”

Section: Discussionmentioning

confidence: 99%

What Is Your Diagnosis? Testicular tumor in a horse

Leidinger¹,

Springler²,

Furman³

et al. 2018

Veterinary Clinical Pathol

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Ultrasound Examination of Unilateral Seminoma in a Salernitano Stallion

Giangaspero

Bucci

Signore

et al. 2022

Animals

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An 18-year-old Salernitano stallion developed a progressive enlargement of the left testicle over eight months. An ultrasound evaluation was performed, along with a hormonal profile. A histopathological evaluation of the testis was performed after unilateral orchiectomy. On B-mode ultrasound examination, testicular parenchyma was characterized by the loss of internal structure, with the presence of multiple coalescing, nodular, well-defined and heterogeneous lesions with capsule deformity, appearing with an irregular profile. On dissection, the testicular parenchyma bulged over the cut section, confirming the increase in size. Microscopically, the lesion consisted mainly of large, densely packed, polygonal-to-round-shaped neoplastic cells. Mitotic figures were plentiful and frequently atypical; further microscopic features included apoptosis and necrosis. At immunohistochemistry, the entire neoplasm showed strong and diffuse immunolabeling for vimentin, while CD117-specific immunoreactivity was only observed in scattered clusters of neoplastic cells. Based on the gross, microscopic and IHC findings, a diagnosis of diffuse seminoma was made. Three months later, a follow-up examination showed no evidence of recurrence and the preservation of reproductive abilities. The case presented shows an unusual ultrasonographic pattern for seminoma and the basis of the correlation between the characteristics of the sonoelastographic examination and histological diagnosis.

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Diffuse type testicular seminoma in a stallion

Cited by 4 publications

References 16 publications

Metastatic Seminoma in a Male Alpine Goat: Clinical and Histopathological Approach

Metastatic Seminoma in a Male Alpine Goat: Clinical and Histopathological Approach

What Is Your Diagnosis? Testicular tumor in a horse

Ultrasound Examination of Unilateral Seminoma in a Salernitano Stallion

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