Diffuse sclerosing variant of papillary carcinoma of the thyroid

Martín-Pérez, Elena; Larrañaga, Eduardo; Serrano, Pedro

doi:10.1080/110241598750005624

Cited by 10 publications

(9 citation statements)

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“…However, the diffuse nature of DSVPTC often mimics chronic thyroiditis on US images and leads to treatment delay, particularly in the absence of a focal solid mass (14,15). In the present case, thyroid ultrasonography revealed diffuse enlargement of each lobe and heterogenous echogenicity without focal solid mass formation.…”

Section: Discussionmentioning

confidence: 54%

“…Currently, ultrasound (US) is generally considered to be the most accurate imaging modality for the evaluation and characterization of thyroid nodules (13). Since DSVPTC always permeates the entire gland causing diffuse thyroid enlargement without a dominant nodule, which is difficult to diagnose using US, it is more commonly diagnosed as Hashimoto's thyroiditis (12,14,15). The present study was the first, to the best of our knowledge, to report shear wave elastography (SWE) diagnosis of DSVPTC of the thyroid.…”

Section: Introductionmentioning

confidence: 99%

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Shear wave elastography diagnosis of the diffuse sclerosing variant of papillary thyroid carcinoma: A case report

Xue

Huang

et al. 2016

Molecular and Clinical Oncology

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Abstract. The present study aimed to report the shear wave elastography (SWE) findings in a patient with the diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC). Since patients with DSVPTC may present with typical clinicopathological features and initially appear to have Hashimoto's thyroiditis, a thorough clinical evaluation and an early diagnosis are important. A 20-year-old female patient presented with a 1-month history of a neck mass and sore throat. Conventional ultrasound and SWE were performed using an AIXPLORER system with 14-5 MHz linear transducer. The patient had undergone total thyroidectomy and bilateral neck lymph node dissection, and an intraoperative pathology consultation to confirm the malignancy of lymph node metastasis. Pathological diagnosis was DSVPTC in both lobes, with lymph node metastases in the bilateral neck. The clinical presentation and serological findings were all indicative of Hashimoto's thyroiditis. Thyroid ultrasonography revealed diffuse enlargement of the both lobes, heterogenous echogenicity without mass formation, diffuse scattered microcalcifications and poor vascularization. SWE revealed stiff values of the thyroid: The mean stiffness was 99.7 kpa, the minimum stiffness was 59.1 kpa and the maximum stiffness was 180.1 kpa. The maximum stiffness of the DSVPTC (180.1 kpa) was higher compared with the diagnostic criteria of malignant thyroid nodules (65 kPa). SWE may be considered as a novel and valuable method to diagnose DSVPC.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Shear wave elastography diagnosis of the diffuse sclerosing variant of papillary thyroid carcinoma: A case report

Xue

Huang

et al. 2016

Molecular and Clinical Oncology

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“…DSVPTC is histologically characterized by diffuse involvement of one or both thyroid lobes with dense fibrosis, extensive squamous metaplasia, patchy lymphoid infiltration with germinal centers, psammoma bodies, and areas of conventional papillary carcinoma (1, 5). The usual ultrasonographic findings of DSVPTC are a round, solid, hypoechoic mass with internal vascularity and microcalcifications, or a diffusely enlarged thyroid gland with hypoechoic and heterogeneous internal echoes containing fine and multiple fine high-echo spots (6-8). The diffuse involvement of the thyroid in DSVPTC and the presence of anti-thyroglobulin antibodies usually mimic Hashimoto's thyroiditis (9).…”

Section: Discussionmentioning

confidence: 99%

“…This issue involving this variant is often delayed diagnosis due to the imaging features mimicking benign thyroid disease such as chronic thyroiditis (8). In our case, the diagnosis was also delayed for the same reason.…”

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma of a Diffuse Sclerosing Variant: Ultrasonographic Monitoring from a Normal Thyroid Gland to Mass Formation

et al. 2010

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A diffuse sclerosing variant of papillary thyroid carcinoma is uncommon and has a tendency for rapid growth and a higher incidence of cervical lymph node metastases. We experienced a case of a diffuse sclerosing variant of papillary thyroid carcinoma in a 48-year-old man. This case showed benign features on initial ultrasonography and positron emission tomography (PET) scan. A new nodule was detected on follow-up ultrasonography that showed rapid enlargement. This case was confirmed by surgical excision. We herein describe the initial and follow-up ultrasonographic findings of a diffuse sclerosing variant of papillary thyroid carcinoma.

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“…Because of its appearance of diffuse enlargement of the thyroid gland, heterogeneous hypoechogenicity on sonography, and increased serum thyroid antibodies, the diffuse sclerosing variant of papillary thyroid carcinoma can be confused with chronic thyroiditis, and correct diagnosis is often delayed 15 . However, the abundant psammoma bodies on histopathologic examination are typical for the diffuse sclerosing variant only, not in patients with chronic thyroiditis.…”

Section: Sonographic and Specimen Radiographic Findingsmentioning

confidence: 99%