Diffuse Chorangiomatosis as a Cause of Cardiomegaly, Microangiopathic Hemolytic Anemia and Thrombocytopenia in a Newborn

Abstract

Diffuse chorangiomatosis can be associated with hemolysis, thrombocytopenia and cardiomegaly in the newborn. However, once delivered, these findings can spontaneously resolve over time.

Reverse diastolic flow of the fetal middle cerebral artery associated with placental chorangiomatosis and asymptomatic concealed placental abruption

“…Villous capillary lesions are rare abnormal placental developmental conditions which include: chorangiosis, chorangiomatosis, and chorangioma [9] , [10] , [11] , [12] . The causes of villous capillary lesions remain unclear, yet appear to involve excessive angiogenesis [9] .…”

“…Bagby and Redline considered their findings to suggest that multifocal chorangiomatosis may represent an abnormal proliferation of the paravascular capillary net in proximal villi related to fetoplacental developmental anomalies and abnormal fetal blood flow [10] . Multifocal chorangiomatosis has been noted in association with adverse perinatal outcomes relating to severe fetal anemia [9 , 12] . Carlucci et al.…”

“…described a case of an infant born by Cesarean at 32 weeks’ gestation. The neonate manifested cardiomegaly, microangiopathic hemolytic anemia, and thrombocytopenia, which resolved over time, and was attributed to diffuse placental chorangiomatosis [12] . Similarly, fetal anemia has been reported in association with placental chorioangioma [13 , 14] .…”

Common Placental Abnormalities Review

“…The hallmark of diffuse chorangiomatosis is capillary dysvasculogenesis, diffusely involving the placenta causing massive placental enlargement. It has been associated with fetal cardiomegaly, microangiopathic hemolytic anemia and thrombocytopenia [22].…”