Fetal disseminated intravascular coagulopathy, hydrops and massive umbilical vein thrombosis consequence of a rare placental condition: multifocal chorangiomatosis

Carlucci, Stefania; Stabile, Guglielmo; Catagini, Silvia; Borghi, Chiara; Scutiero, Gennaro; Morano, Danila; Greco, Pantaleo

doi:10.1080/14767058.2020.1843154

Cited by 7 publications

(11 citation statements)

References 17 publications

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Section: Discussionmentioning

confidence: 99%

“…Villous capillary lesions are rare abnormal placental developmental conditions which include: chorangiosis, chorangiomatosis, and chorangioma [9] , [10] , [11] , [12] . The causes of villous capillary lesions remain unclear, yet appear to involve excessive angiogenesis [9] . A study of 53 cases of multifocal chorangiomatosis (among 5429 consecutively accessioned placentas > 20 weeks’ gestation) noted that approximately half of the placentas with multifocal chorangiomatosis exhibited avascular villi, villous chorangiosis, and distal villous immaturity.…”

Section: Discussionmentioning

confidence: 99%

“…Bagby and Redline considered their findings to suggest that multifocal chorangiomatosis may represent an abnormal proliferation of the paravascular capillary net in proximal villi related to fetoplacental developmental anomalies and abnormal fetal blood flow [10] . Multifocal chorangiomatosis has been noted in association with adverse perinatal outcomes relating to severe fetal anemia [9 , 12] . Carlucci et al.…”

Section: Discussionmentioning

confidence: 99%

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Reverse diastolic flow of the fetal middle cerebral artery associated with placental chorangiomatosis and asymptomatic concealed placental abruption

Sherer

Makanjoula

Field

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reverse diastolic flow of the fetal middle cerebral artery associated with placental chorangiomatosis and asymptomatic concealed placental abruption

Sherer

Makanjoula

Field

et al. 2023

Radiology Case Reports

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“…Placental abnormalities still represent an unsolved problem responsible for a high rate of fetal compromise [7,8]. The placenta often plays a principal role, estimated at between 52% and 64%, in fetal or perinatal death, comparing different stillbirth classifications [9,10].…”

Section: Discussionmentioning

confidence: 99%

Umbilical Cord Knots: Is the Number Related to Fetal Risk?

Stabile

Carlucci²,

Bonis

et al. 2022

Medicina

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True knots of the umbilical cord (UC) are a rare occurrence and are reported in 0.4–1.2% of deliveries. The compression of true knot of the UC can cause obstruction of the fetal circulation, leading to intra-uterine growth retardation or fetal death. Predisposing factors for the genesis of the true UC knot are numerous and include all the conditions, which lead to a relatively large uterine volume. This situation may predispose to free and excessive fetal movements. Although not all true knots lead to perinatal complications, they have been associated with adverse pregnancy outcomes, including fetal distress, fetal hypoxia, intra-uterine growth restriction (IUGR), long-term neurological damage, caesarean delivery and stillbirth. We present a rare case of operative delivery with vacuum in a multiparous woman at term of pregnancy with a double true knot of the UC. As in most cases, the diagnosis was made after delivery, as there were no fetal symptoms during pregnancy. Some authors assume that 3D power sonography may be useful in the diagnosis of true UC knots. However, 3D power Doppler cannot be considered as a definitive method. There are no specific prenatal indications to induce the physician to look for ultrasound signs suggestive of umbilical true knot. Some studies argue that cases of fetal death and fetal risk are directly related to the number of knots. We also support this thesis, even if further observational and retrospective studies are needed to demonstrate it.

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“…Placental chorioangioma is a fetal-stromal vascular lesion, being part of a wider subgroup of lesions, called villous capillary lesions, which includes the following variants characterized by excessive angiogenesis: chorioangiosis (presence of more than 10 capillaries per terminal villus in at least 10 villi within several placental regions), chorioangiomatosis (represented by small anastomosing capillaries mostly in the tip of placental stem and immature intermediate villi), chorioangioma (similar to chorioangiomatosis for stem and immature intermediate villi involvement but different for the formation of a nodular expansile lesion) and multiple chorioangioma syndrome, an infrequent variant with several concomitant chorioangiomas occupying up to 80% of the total volume of placental parenchyma [1][2][3][4]. Chorioangioma with trophoblast proliferation is an additional condition to be accounted for differential diagnosis with the histological forms mentioned above.…”

Section: Introductionmentioning

confidence: 99%

CD133 Expression in Placenta Chorioangioma Presenting as a Giant Asymptomatic Mass

et al. 2021

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Background: Placental chorioangioma is the most common benign non-trophoblastic neoplasm of the placenta. Its clinical relevance lies in the size of the tumor since larger masses cause pregnancy complications, including an unfavorable neonatal outcome. Case presentation: We report the case of a 34-year-old second gravida and nullipara at the 35th week of gestation, admitted to the gynecological department for antibiotic-resistant fever. The cardiotocography performed during hospitalization showed an abnormal fetal pattern. A 2250 g newborn was delivered by cesarean section. No complications were observed during childbirth and postpartum was insignificant. On gross inspection a white fleshy intraparenchymal mass blooming on the maternal surface was noted; routinely stained sections revealed features consistent with chorioangioma with vascular channels lined by inconspicuous endothelial cells immunoreactive for CD31 and CD133. Focal expression of CD133 was also observed in placental villi. Discussion: CD133 expression indicated the presence of stem cells in chorioangioma, suggesting their possible role in the development of mesenchymal lesions including chorioangioma.

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Fetal disseminated intravascular coagulopathy, hydrops and massive umbilical vein thrombosis consequence of a rare placental condition: multifocal chorangiomatosis

Cited by 7 publications

References 17 publications

Reverse diastolic flow of the fetal middle cerebral artery associated with placental chorangiomatosis and asymptomatic concealed placental abruption

Reverse diastolic flow of the fetal middle cerebral artery associated with placental chorangiomatosis and asymptomatic concealed placental abruption

Umbilical Cord Knots: Is the Number Related to Fetal Risk?

CD133 Expression in Placenta Chorioangioma Presenting as a Giant Asymptomatic Mass

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