Differing energy densities with laser 670 nm InGaP controls inflammation and collagen reorganization in burns

Maligieri, Luis Angelo Ozan; Neves, Lia Mara Grosso; Morais, Driele Talita de; Domingues, Rayane Ferreira; Aro, Andréa Aparecida de; Pimentel, Edson Rosa; Amaral, Maria Esméria Corezola do; Esquisatto, Marcelo Augusto Marretto; Santos, Gláucia Maria Tech dos; Mendonça, Fernanda Aparecida Sampaio

doi:10.1016/j.burns.2017.04.008

Cited by 13 publications

(11 citation statements)

References 50 publications

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“…The difference between the results of MMP9 gene expression in the studies can be explained by the use of different laser sources, energy intensity, wavelength, as well as the data analysis timing (short or long term). The findings are compatible with the study by Maligieri et al 18 that used different energy densities for treatment. In addition, there are indications that MMP9 may play a role in physiological and pathological tissue remodeling of central nervous system through a new regulatory pathway of TGF-β1 in brain astrocytes 18 .…”

Section: Discussionsupporting

confidence: 93%

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Light-emitting diode stimulates radiodermatitis recovery

et al. 2021

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To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. Methods: Ten male Wistar rats weighing 200-250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). Results: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis (p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. Conclusion: This study suggested that the use of LED for radiodermatitis increased skin regeneration.

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Section: Discussionsupporting

confidence: 93%

“…The findings are compatible with the study by Maligieri et al 18 that used different energy densities for treatment. In addition, there are indications that MMP9 may play a role in physiological and pathological tissue remodeling of central nervous system through a new regulatory pathway of TGF-β1 in brain astrocytes 18 .…”

Section: Discussionsupporting

confidence: 93%

Light-emitting diode stimulates radiodermatitis recovery

et al. 2021

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“…Resolvin D2 has recently been found to restore burn neutrophil directionality and can reduce neutrophil numbers and minimise secondary necrosis in burns [85,86]. The use of phototherapy has been shown to significantly reduce the number of immune cells within a rat burn wound, increasing angiogenesis and collagen deposition [87] and may herald a new area of research for the development of devices to treat burn wounds. Novel biomaterials are also being investigated in the treatment of burn injuries, not only to provide a provisional matrix or augment skin grafting, but are also being assessed for their ability to modulate the immune response [88].…”

Section: Enhancement Of the Resolution Of The Inflammatory Responsementioning

confidence: 99%

The Role of the Inflammatory Response in Burn Injury

Strudwick¹,

Cowin²

2018

Hot Topics in Burn Injuries

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Burns are characterised by significant local swelling and redness around the site of injury, indicative of acute inflammation. Whilst the inflammatory response is fundamental to the healing process, triggering a cascade of cytokines and growth factors to protect against the risk of infection, it is clear that prolonged inflammation can be detrimental and lead to scarring and fibrosis. Severe burns may display chronic, persistent inflammation long after the initial burn injury and may even result in multiple organ failure (MOF) due to systemic inflammatory response syndrome (SIRS). Excessive inflammation in the early stages of healing has been identified as a causative factor in the formation of scars which can be disfiguring, functionally restrictive and may require revisionary surgeries. Therefore, it is imperative that inflammation is effectively managed following burn injuries in order to optimise the benefits it provides whilst actively preventing the complications of inflammation including SIRS, multiple organ failure (MOF) and the development of scarring and fibrosis. Reviewing the current knowledge about the role of the inflammatory response in burns and the treatments available for the management of inflammation during wound healing, highlights the importance of continued research into understanding and developing new approaches to regulate inflammatory responses post-burn injuries.

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“…Prolongation and expansion of the inflammatory phase is the most important factor in scar formation [36]. Scar formation is affected by the depth of the burn, the duration of the healing, the development of infection, the age of the patient, genetic factors, circulatory disturbances, or the development of diseases that suppress the immune system [37].…”

Section: Burn Scarsmentioning

confidence: 99%

Burn Etiology and Pathogenesis

Kara¹

2018

Hot Topics in Burn Injuries

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As a trauma type, "Burn" is one of the high-frequency accidents in the world. It is mostly caused by electricity, hot water, and chemical agents. A trauma can have acute effects on burns, skin, and other organ systems. These complications might be seen as myocardial infarction, thromboemboli, respiratory, and renal failure. In case of acute burns, the skin surface is severely destroyed. During this period, infection may develop on damaged skin. Therefore, in the treatment of burn wounds, protecting the damaged skin and multidisciplinary approaches are needed for preventing scar formation while healing process.

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Differing energy densities with laser 670 nm InGaP controls inflammation and collagen reorganization in burns

Abstract: The energy density of 9.86J/cm was more effective in promoting cellular responses related to neoangiogenesis, decreasing inflammation and collagen fibers reorganization.

Cited by 13 publications

References 50 publications

Light-emitting diode stimulates radiodermatitis recovery

Light-emitting diode stimulates radiodermatitis recovery

The Role of the Inflammatory Response in Burn Injury

Burn Etiology and Pathogenesis

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