Differentiation Potential of Adult Human Mesenchymal Stem Cells

Tobiasch, Edda

doi:10.1007/978-3-642-11865-4_3

Cited by 31 publications

(13 citation statements)

References 29 publications

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“…Today, stem cell-based approaches enable the development of individualized patient-specific solutions [123,124,125]. The first step in cell–scaffold interactions are adhesion processes related to intensive interactions on cell–biomaterial surfaces and interfaces.…”

Section: Si-containing Scaffolds For Stem Cell-based Bone Formationmentioning

confidence: 99%

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

et al. 2019

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Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.

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Section: Si-containing Scaffolds For Stem Cell-based Bone Formationmentioning

confidence: 99%

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

et al. 2019

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“…Osteoinductivity in xenografts can be achieved by the incorporation of autologous cells, like mesenchymal stem cells (MSCs), that can be obtained from bone marrow or adipose tissue [ 22 , 23 ]. The embodiment of mesenchymal stem cells led to a higher integration of the graft to the bone, compared to the xeno-derived bone alone, since the cells are able to differentiate towards osteoblasts [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Ottensmeyer

Witzler

Schulze

et al. 2018

IJMS

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The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount of accessible material demands new sources of bone replacement. The use of mesenchymal stem cells or their descendant cells, namely osteoblast, the bone-building cells and endothelial cells for angiogenesis, combined with artificial scaffolds, is a new approach. Mesenchymal stem cells (MSCs) can be obtained from the patient themselves, or from donors, as they barely cause an immune response in the recipient. However, MSCs never fully differentiate in vitro which might lead to unwanted effects in vivo. Interestingly, purinergic receptors can positively influence the differentiation of both osteoblasts and endothelial cells, using specific artificial ligands. An overview is given on purinergic receptor signaling in the most-needed cell types involved in bone metabolism—namely osteoblasts, osteoclasts, and endothelial cells. Furthermore, different types of scaffolds and their production methods will be elucidated. Finally, recent patents on scaffold materials, as wells as purinergic receptor-influencing molecules which might impact bone grafting, are discussed.

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“…Mesenchymal stem cells (MSC) are multipotent cells that can be obtained from several tissues including bone marrow, umbilical cord, peripheral blood, wisdom teeth, and fat [5] , [77] , [78] , [79] , [80] . To define these cells most researchers agree and rely on the minimal criteria defined by the International Society of Cellular Therapy where MSCs should adhere to plastic under standard culture conditions, and must be able to differentiate into osteoblasts, adipocytes and chondroblasts under standard in vitro differentiating conditions, as confirmed by specific stainings.…”

Section: Stem Cellsmentioning

confidence: 99%

The role of purinergic receptors in stem cell differentiation

Kaebisch

Schipper

Babczyk

et al. 2015

Computational and Structural Biotechnology Journal

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A major challenge modern society has to face is the increasing need for tissue regeneration due to degenerative diseases or tumors, but also accidents or warlike conflicts. There is great hope that stem cell-based therapies might improve current treatments of cardiovascular diseases, osteochondral defects or nerve injury due to the unique properties of stem cells such as their self-renewal and differentiation potential. Since embryonic stem cells raise severe ethical concerns and are prone to teratoma formation, adult stem cells are still in the focus of research. Emphasis is placed on cellular signaling within these cells and in between them for a better understanding of the complex processes regulating stem cell fate. One of the oldest signaling systems is based on nucleotides as ligands for purinergic receptors playing an important role in a huge variety of cellular processes such as proliferation, migration and differentiation. Besides their natural ligands, several artificial agonists and antagonists have been identified for P1 and P2 receptors and are already used as drugs. This review outlines purinergic receptor expression and signaling in stem cells metabolism. We will briefly describe current findings in embryonic and induced pluripotent stem cells as well as in cancer-, hematopoietic-, and neural crest-derived stem cells. The major focus will be placed on recent findings of purinergic signaling in mesenchymal stem cells addressed in in vitro and in vivo studies, since stem cell fate might be manipulated by this system guiding differentiation towards the desired lineage in the future.

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Differentiation Potential of Adult Human Mesenchymal Stem Cells

Cited by 31 publications

References 29 publications

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

The role of purinergic receptors in stem cell differentiation

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