Differentiating between Glioblastoma and Primary CNS Lymphoma Using Combined Whole-tumor Histogram Analysis of the Normalized Cerebral Blood Volume and the Apparent Diffusion Coefficient

Abstract

Our results suggest that whole-tumor histogram analysis of nCBV and ADC combined can be a valuable objective diagnostic method for differentiating between GBM and PCNSL.

MRI as a diagnostic biomarker for differentiating primary central nervous system lymphoma from glioblastoma: A systematic review and meta‐analysis

“…Detailed information of excluded studies is described in the Supplementary Materials. One further relevant study was also identified, resulting in a final total of 22 studies investigating the diagnostic performance of MRI for differentiating PCNSL from glioblastoma, with these studies covering 1182 patients.…”

“…A variety of MRI sequences were used in various combinations (Table ), with the most commonly used sequences being DWI in 14 studies, DSC in nine studies, and DCE in four studies . The other less‐commonly used sequences were ASL in four studies, SWI in four studies, MRS in three studies, and IVIM in two studies .…”

“…In terms of the ROI placement, the entire enhancing tumor was selected in 14 studies, and both the entire enhancing tumor and peritumoral area were selected in seven studies . A variety of different cutoff values were used, with multiparametric MRI sequences being used to determine optimal cutoff values in 11 studies . MRI was interpreted by 1–3 neuroradiologists, with the readers being blinded to the reference standard in six studies …”

“…Three studies utilized a prospective design, 18,20,25 while the others were of a retrospective design. Seven studies enrolled patients in a consecutive manner, 6,8,12,[18][19][20]25 while the enrollment was not explicit in the others. Nineteen studies used only histopathology as the reference standard, [4][5][6][7][8][9][10][11][13][14][15][16]18,[20][21][22][23][24][25] while two studies used histopathology and clinicoradiologic diagnosis for patients with PCNSL.…”

“…During the last decade, multiple MRI sequences have been introduced for differentiating PCNSL from glioblastoma . These sequences, which include diffusion‐weighted imaging (DWI), dynamic susceptibility‐weighted contrast‐enhanced imaging (DSC), dynamic contrast‐enhanced imaging (DCE), arterial spin labeling (ASL), susceptibility‐weighted imaging (SWI), intravoxel incoherent motion (IVIM), and magnetic resonance spectroscopy (MRS), have demonstrated variable diagnostic performance.…”