Differentiating glioblastoma from primary central nervous system lymphoma of atypical manifestation using multiparametric magnetic resonance imaging: A comparative study

Feng, Aozi; Li, Li; Huang, Tao; Li, Shuna; He, Ningxia; Huang, Liying; Zeng, Mengnan; Lyu, Jun

doi:10.1016/j.heliyon.2023.e15150

Cited by 2 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rCBVt values and rCBVt/n ratios were 2.34±1.16 and 1.49±1.09 for patients with PCNSLs and 8.41±2.05 and 5.02±2.25 for patients with GBMs. The aforementioned values were substantially higher than those of Neska-Matuszewska et al ( 15 ), who reported rCBVt values of 0.80±0.35 for PCNSLs and 3.10±1.50 for GBMs, and Feng et al ( 16 ), who reported rCBVt values of 2.17±0.67 for PCNSLs and 2.38±0.62 for GBMs. The markedly higher rCBV values of the present study may be explained by differences in DSC-PWI measurement methods.…”

Section: Discussionmentioning

confidence: 57%

“…The present study evaluated the multiparametric diagnostic performance of DWI and DSC-PWI to facilitate the preoperative differentiation of PCNSL and GBM which are similar to several other studies ( 15 , 16 , 18-20 ). To differentiate GBMs and PCNSLs, it was suggested a cutoff value of 4.15 for rCBVt, which had 100% Se and 94% Sp with an excellent AUC of 0.996.…”

Section: Discussionmentioning

confidence: 72%

“…Lee et al ( 3 ) reported minimum ADC values for PCNSLs and GBMs of 0.595±0.228x10 -3 and 0.737±0.162x10 -3 mm 2 /s, respectively, and minimum ADC ratios for PCNSLs and GBMs of 0.87±0.26 and 1.14±0.29, respectively. Feng et al ( 16 ) reported minimum ADC values for PCNSLs and GBMs of 0.68±0.10x10 -3 and 0.77±0.07x10 -3 mm 2 /s, respectively, and relative ADC for PCNSLs and GBMs of 1.13±0.12 and 1.32±0.19, respectively. In contrast to the present study, a previous study of 20 patients by Bao et al ( 17 ) showed that although ADC parameters were larger in GBM compared with those in PCNSL, but these differences were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…This difference could be explained by the whole-tumor histogram analysis which be affected by the tumor size (larger tumors will have a greater impact on total tumor diffusion metrics compared with smaller tumors). Furthermore, these studies ( 3 , 16 , 17 , 29 ) did not evaluated the peritumoral edema.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the minimum ADC from DWI and the rCBV from DSC-PWI are the most important hemodynamic parameters for differentially diagnosing GBMs and PCNSLs ( 15 ). However, numerous studies have discussed only assessments of tumor cores ( 3 , 16-20 ), with peritumoral regions less frequently evaluated ( 15 , 21 ). To the best of our knowledge, very few studies have evaluated usefulness of multiparametric DSC-PWI and DWI of tumor core and peritumoral zone in the preoperative differentiation of GBMs and PCNSLs.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging

Duy Hung,

Ngoc Anh,

Dinh Minh

et al. 2023

Biomed Rep

View full text Add to dashboard Cite

The present study aimed to determine whether combining diffusion-weighted (DWI) and dynamic susceptibility contrast-enhanced perfusion-weighted (DSC-PWI) magnetic resonance imaging (MRI) could differentiate between primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM). The present retrospective study evaluated 45 patients with histologically confirmed brain tumors, of which 18 had PCNSLs and 27 had GBMs. All patients underwent conventional, DWI, and DSC-PWI MRIs before the surgical removal of the lesion or stereotactic biopsy. The solid tumor component, peritumoral edema, and abnormal white matter were measured in three regions of interest to evaluate relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and DWI. In conventional MRI, there were significant differences in tumor numbers, tumor enhancement type, tumor necrosis, hemorrhage and open-ring sign between GBM and PCNSL. Solid tumor ADC and rCBV values (ADCt and rCBVt, respectively) and their ratios with abnormal white matter amounts were significantly higher in GBM cases than in PCNSL cases (P<0.05). The rCBV value for peritumoral edema (rCBVe) and its ratio with abnormal white matter amount (rCBVe/n) were significantly higher in GBM cases than in PCNSL cases (P<0.05). However, ADC values did not differ significantly for peritumoral edema. DWI values did not differ significantly. Combining rCBVt and rCBVe/n provided a perfect area under the receiver operating characteristic curve of 1.00, with 100% sensitivity and 100% specificity for distinguishing GBM from PCNSL. In the results of the present study, the major criterion in the decision-making process distinguishing PCNSL from GBM was the combined rCBVt and rCBVe/n parameter. A minor criterion was the ADCt value of the lesion.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging

Duy Hung,

Ngoc Anh,

Dinh Minh

et al. 2023

Biomed Rep

View full text Add to dashboard Cite

show abstract

CNS Involvement of DLBCL Presenting with an Unusual Non-Enhancing Infiltrative Mass

Hsueh,

Chen,

Tzeng

2023

Diagnostics

View full text Add to dashboard Cite

Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) is relatively uncommon, occurring in approximately 5% of cases, with the majority of instances manifesting during relapse and often associated with poor prognoses. The aim of this case report is to present a unique occurrence of non-enhancing relapse of CNS lymphoma. Significantly, the patient had recently encountered a disease involvement in the axilla region, and subsequent to scheduled chemotherapy, she developed persistent neurological symptoms, leading to the discovery of a relapse of the CNS lymphoma. Our focus will be on delineating the clinical presentation, elucidating the findings observed in clinical imaging, and detailing the therapeutic approaches employed in this specific case. By highlighting these aspects, we aim to provide valuable insights into the diagnosis of the atypical presentation of CNS lymphoma.

show abstract

Differentiating glioblastoma from primary central nervous system lymphoma of atypical manifestation using multiparametric magnetic resonance imaging: A comparative study

Cited by 2 publications

References 35 publications

Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging

Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging

CNS Involvement of DLBCL Presenting with an Unusual Non-Enhancing Infiltrative Mass

Contact Info

Product

Resources

About