Role of intra-tumoral vasculature imaging features on susceptibility weighted imaging in differentiating primary central nervous system lymphoma from glioblastoma: a multiparametric comparison with pathological validation

Differentiation between primary central nervous system lymphomas and gliomas according to pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging

“…Existing studies have reported inconsistent findings regarding the differences in PPs derived from DCE-MRI between these two tumor types. Similar to our results, some studies have demonstrated that the microvascular permeability constants of PCNSL, such as the K trans , and/or K ep values, were lower than those of GBM or HGG [ 11 , 12 , 15 ]. In contrast, some studies have demonstrated that there is no difference in the K trans or K ep of DCE-MRI between the two tumors [ [7] , [8] , [9] , 13 , 14 ].…”

“…PPs, especially K trans , show a strong correlation with glioma grade [ 4 ]. However, there are different opinions on the reliability of using PPs in isolation for PCNSL, and most investigators are interested in enhancing the tumor parenchyma and not the peritumoral parenchyma [ [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] ]( Table 1 ). Theoretically, in GBM and PCNSL, abnormal peritumoral parenchyma signals are caused not only by changes in interstitial water but also by scattered tumor cell infiltration.…”

Distinctive magnetic resonance imaging features in primary central nervous system lymphoma: A case report

“…The imaging findings of PCNSL are closely related to its pathological features. In this case, the lesions were confined to the brain tissue, involving both supratentorial and infratentorial areas, which is relatively rare[ 7 ].…”