Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice

Abstract

These findings suggest that 5-HT1A receptors modulate the analgesic and the antidepressant-like effects of tramadol in differing ways. The results suggest the involvement of the 5-HT1A autoreceptors from the raphe nuclei and spinal 5-HT1A receptors in the antinociceptive effect. In contrast, the 5-HT1A receptors located in the forebrain may be responsible for the blockade of the antidepressant-like effect of tramadol. 5-HT1B receptors seem not to modify these effects in the models investigated.

Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats

“…In the present study, s.c. administration of a 5-HT 1A receptor agonist alone had a slight tendency to increase allodynia in neuropathic animals, although not significantly. This is in line with our previous studies and other evidence indicating that systemic administration of a 5-HT 1A receptor agonist or antagonist had little effect on baseline nociception in healthy, diabetic and mononeuropathic animals (Ardid et al 2001;Berrocoso et al 2006b;Roca-Vinardell et al 2003;Rojas-Corrales et al 2000. However, some data indicate that WAY-100635, administered either systemically or into the rostroventromedial medulla, produces a selective attenuation of mechanical hypersensitivity in animals with an experimental neuropathy (Wei and Pertovaara 2006).…”

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

“…There is an interaction between HTR1B and HTR2B [80], and between HTR1B and aging as well [28,154]. Moreover, the role with regard to nociception of HTR1B has been extensively investigated [15,84,94,111,139], and a modulation of psychiatric disruption in terms of an altered nociceptive signal computation could be hypothesized.…”

Beta-endorphin response to an acute pain stimulus

“…A hot-plate (15.9 × 15.9) insulated with polystyrene (Thermolyne Aluminum Type, Model HPA1915B, Dubuque, IA) was maintained at 55 ± 1 • C by a temperature controller (GlasCol, PowrTrol Model, Terre Haute, IN) and monitored using a thermo-coupled thermometer (Omega, Model HH11, Stamford, CT). In order to confirm that pain had been experienced by exposure to the hot-plate, the animal's paw-licking response was observed (Pierretti et al, 1993;Rubenstein et al, 1996;Liang et al, 2003;Rasmussen and Farr, 2003;Vermeirsch and Meert, 2004;Wesolowska et al, 2004;Suaudeau et al, 2005;Altug et al, 2006;Berrocoso et al, 2006;Smith and Lindsay, 2007;Hsieh et al, 2008;Milano et al, 2008). Exposure of a mouse to a 55 • C hot-plate induces the paw-licking response and the mouse begins to lick its front or hind paws.…”