Beta-endorphin response to an acute pain stimulus

Rasmussen, Natalie Ann; Farr, Lynne

doi:10.1016/j.jneumeth.2008.10.013

Cited by 27 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The IL-6 and β -endorphin levels may be useful objective indicators of pain in animals [2, 36]. Over the years, numerous studies on the role of cytokines in pain control have been conducted.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

Subcutaneous (SC) administration of tramadol was compared with intravenous (IV) administration to evaluate analgesia following canine ovariohysterectomy (OHE). Healthy female dogs (n = 12) between 1 and 3 years of age (1.95 ± 0.65 years), weighing between 10.5 and 17.1 kg (13.12 ± 1.95 kg), were used. Pain was assessed at baseline before surgery and then hourly for 8 hr after surgery. Tramadol was administered both SC and IV at a dose of 3 mg/kg and provided significant postoperative analgesia, as indicated by analgesiometry, β-endorphin levels, and interleukin 6 (IL-6) levels. The respiratory rates and rectal temperatures remained normal and were not significantly different between or within the groups. A significant increase in heart rate was observed at 4 hr for dogs in both groups relative to the baseline, but there was no significant difference in heart rates between the groups at any time point. A significant decrease in mechanical pain threshold was observed within each group after surgery, but both groups responded similarly, suggesting that SC administration of tramadol is as effective as IV administration. Increased serum levels of both IL-6 and β-endorphin 3 hr postoperatively further indicate that both routes of administration achieve similar pain control. Thus, the relative analgesic efficacy of SC tramadol is comparable to that of IV administration and can be used to achieve similar effects for postsurgical pain management in dogs undergoing OHE.

show abstract

Section: Discussionmentioning

confidence: 99%

“…β -endorphin plays a significant role as biomarker [36] and modulator in acute traumatic conditions such as surgery [41]. Measurements of plasma concentrations of β -endorphin have been used extensively in the assessment of pain following castration and tail docking [42].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…Generally, regular exercise increases cardiovascular fitness, muscular strength and flexibility and women who exercise are less likely to be overweight or obese 15 16. Aerobic exercise leads to endorphins production which may reduce sensitivity to pain and produce feelings of relaxation 17. Thus exercise could potentially influence the risk of developing pelvic girdle pain in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Exercise level before pregnancy and engaging in high-impact sports reduce the risk of pelvic girdle pain: a population-based cohort study of 39 184 women

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Since endorphins play a pivotal role in pain modulation and analgesia (41)(42)(43), sex difference to noxious thermal stimulation can be attributed to different brain endorphins content of males compared with females (44).…”

Section: Discussionmentioning

confidence: 99%

sex difference and effects of gonadal hormones on thermal pain thershold in rat

Ahmadi¹

2009

Acta Endo (Buc)

View full text Add to dashboard Cite

Various clinical and experimental studies indicate that gonadal hormones exert modulatory effects on nociception and analgesia.The aim of the present study was to investigate the role of gonadal hormones in the response by male and female rats to thermal nociceptive stimulation.Materials and Methods. 7 week old albino (Wistar) rats were used in our study. Animals were randomly divided into control, sham and ovariectomised or orchidectomised groups. Thermal pain threshold was measured through tail immersion test before and 10, 20 or 40 days after gonadectomy. The pain threshold was measured as the time required to elicit a flick of the tail called analgesia time. Serum testosterone, estradiol, progesterone or prolactin levels were measured simultaneously.The results showed that analgesia time was higher in female (5.11 min) than in male (4.93 min) intact animals (p<0.05) indicating sex difference in response to thermal nociception. Serum testosterone, estradiol or progesterone level as well as analgesia time were not significantly reduced 10 days after gondectomy. In male animals, analgesia time was significantly decreased (p<0.01) 20 or 40 days after orchidectomy (2.25 or 2.14 min, respectively) compared with control rats (4.93 min). Serum testosterone concentration was significantly reduced (p<0.05) 20 or 40 days after orchidectomy (0.08 or 0.09 ng/mL, respectively) compared with control serum testosterone level (2.14 ng/mL). In female rats, analgesia time was significantly decreased (p<0.001) 20 or 40 days after ovariectomy (2.87 or 2.66 min, respectively) compared with control rats (5.11 min). Serum estradiol concentration was significantly reduced (p<0.001) 20 or 40 days after ovariectomy (3.17 or 0.87 ng/mL, respectively) compared with control serum estradiol level (19.95 ng/ml). Serum progesterone level was also decreased (p<0.001) 20 or 40 days after orchidectomy (5.27 or 0.55 ng/mL, respectively) compared with control serum estradiol level (17.66 ng/mL). Serum prolactin level was not significantly enhanced during experiment indicating that there was not heat stress influencing the procedure.Conclusively, our findings clearly indicate that depletion of gonadal hormones 20 or 40 days after gonadectomy modulates the pain-induced behavioral responses related to thermal nociception.

show abstract

Beta-endorphin response to an acute pain stimulus

Cited by 27 publications

References 31 publications

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Exercise level before pregnancy and engaging in high-impact sports reduce the risk of pelvic girdle pain: a population-based cohort study of 39 184 women

sex difference and effects of gonadal hormones on thermal pain thershold in rat

Contact Info

Product

Resources

About