“…In intact animals, ovulation did not occur after blockade of the cholinergic system by atropine implants in the right side of the POA-AHA on oestrus, and was nor¬ mal when the implant was in the left side ); opposite results were obtained from hemi¬ ovariectomized animals. These results agree with the hypothesis that there exists a direct neural connection between the gonads and the central nervous system which participates in the fine tuning of the effects of gonadotrophins on the gonads (Domínguez & Riboni, 1971;Burden, 1978;Gerendai, Rotszthjn, Marchetti & Scapagnini, 1979;Kawakami, Kubo, Uemura & Hayashi, 1981;Kawakami, Nishihara & Ohno, 1983;Nance, Bhargava & Myatt, 1984;Cook, 1987;Gerendai, 1988;Frankel, Chapman & Cook, 1989;Domínguez, 1990). When the animals were hemiovariectomized, the neural information arising from the extirpated ovary was missing, and the nervous centres adapted to the new situation.…”