Effects of unilateral or bilateral superior ovarian nerve section in infantile rats on follicular growth

Morán, Carolina; Morales, Leticia; Quiróz, Ubaldo; Domı́nguez, Roberto

doi:10.1677/joe.0.1660205

Cited by 20 publications

(12 citation statements)

References 22 publications

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“…In the present experiment, the most pronounced decrease in the secretion of E 1 , E 2 and LH was observed in gilts with denervated ovaries during the perioestrous period. A similar phenomenon was reported earlier in rats (Lara et al, 1990b;Moran et al, 2000) as well as in gilts (Jana et al, 2005). A lack of the preovulatory LH surge in the gilts after neurectomy, found in our study, was probably caused by a decrease in oestrogen concentration during the perioestrous period, leading to a disturbance in positive and negative feedback of LH secretion.…”

Section: Discussionsupporting

confidence: 89%

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Jana

Dzienis

Wojtkiewicz

et al. 2007

Acta Veterinaria Hungarica

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Changes in both the morphology and the steroidogenic activity of porcine ovaries denervated surgically on day 12 of the oestrous cycle were studied. Neurectomy of the plexus and the superior ovarian nerves caused a dramatic reduction in the number (or even a disappearance) of dopamine-β-hydroxylaseand/or neuropeptide tyrosine-immunoreactive nerve terminals. On day 20 of the subsequent oestrous cycle, the number of small follicles increased (P < 0.01) and that of large follicles decreased (P < 0.05) in the denervated ovaries, as compared to the controls. Neurectomy led to a decrease in the level of progesterone (P 4 ; P < 0.001) and androstenedione (A 4 ; P < 0.01) in the fluid from small follicles, A 4 (P < 0.001) and testosterone (T; P < 0.05) in the fluid from medium-sized follicles, as well as in the content of all these steroids in the fluid from large-sized follicles (P < 0.001 for P 4 and P < 0.05 for A 4 and T). Denervation also caused a decrease in the content of A 4 (P < 0.01) and T (P < 0.001) in the wall of follicles. Neurectomy resulted in a significant increase in the immunoexpression of cholesterol side-chain cleavage cytochrome P450 in the follicles and a decrease of 3β-hydroxysteroid dehydrogenase. After denervation, plasma levels of LH, P 4 , A 4 , T, oestrone and oestradiol-17β were lower (P < 0.05-0.001) on the particular days of the study than in the control group. Our data revealed that the denervation of ovaries during the middle luteal phase of the oestrous cycle in gilts caused distinct changes in both the morphology and the steroidogenic activity of the organ, confirming an important role of the peripheral nervous system in the control of the gonad in this species. Acta Veterinaria Hungarica 55, 2007It is well known that mammalian ovaries are fairly innervated by fibres belonging to the adrenergic, cholinergic and/or peptidergic subsets of the autonomic and sensory systems. Ovarian function is thus regulated by both hormonal and neuronal input operating in concert to control follicular development, steroidogenesis and ovulation. Numerous studies performed on laboratory animals showed that the effects of gonad denervation are dependent not only on species and age of animals, but also on the experimental procedure. For instance, the blockade of ovarian innervation development in neonatal rats resulted in limited follicular growth, delayed puberty, decreased oestradiol-17β (E 2 ) secretion and marked irregularities of the oestrous cycles (Lara et al., 1990a). Conversely, chemical sympathectomy induced by guanethidine administration to newborn guinea pigs caused ovulation (Riboni et al., 1997). Although bilateral sectioning of the superior ovarian nerve (SON) in adult rats did not affect ovulation (Chávez et al., 1991), it was able to decrease the plasma levels of progesterone (P 4 ) and E 2 (Erskine and Weaver, 1988). On the other hand, an inhibition of this process occurred in adult guinea pigs exposed to guanethidine (Trujillo and Riboni, 2002). Moreover, it was indicated by Luna et al. ...

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Section: Discussionsupporting

confidence: 89%

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Jana

Dzienis

Wojtkiewicz

et al. 2007

Acta Veterinaria Hungarica

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“…The degree of participation of the SON in the ovarian compensatory hypertrophy depends on the estrus cycle stage in which the ovariectomy and SON transection are performed (Chá vez and Dominguez, 1994). Participation of the SON has also been reported in the exogenous gonadotropin administration effect in juvenile animals, and a different estradiol and progesterone level has been observed at distinct times after SON transection (Morales et al, 1998;Moran et al, 2000).…”

Section: Innervation and Ovarian Functionmentioning

confidence: 90%

Role of the central and peripheral nervous system in the ovarian function

Aguado

2002

Microscopy Res & Technique

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This review attempts to give a comprehensive overview of ovarian innervation, considering the whole nervous system and its different levels that may modify the ovarian function. The connection between the ovary and the central nervous system through the autonomic pathways, including the peripheral ganglia, is highlighted. The evidence obtained over the last years highlights the role of the superior ovarian nerve (SON) in the ovarian phenomena. Besides, the effect on the ovary of conventional neurotransmitters and others such as indolamines and peptides, which have been found in this organ, are discussed. Various reproductive diseases have been studied almost exclusively from the endocrine point of view. It is evident that a better knowledge about the role of the neural factors involved in the ovarian physiology may facilitate the understanding of some of these. A review of the concepts and an update of some experimental designs is made that permits clarifying several aspects of the relationship between the neural system and the ovary. At present, there is no doubt that the innervation of the ovary is involved in several physiological aspects of this gland function. However, the relationship of some levels of the nervous system and the ovary offer a wide avenue for future research.

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“…A similar effect is found in rats, where a bilateral denervation of the SON decreases the serum level of oestradiol, progesterone and the number of developing follicles. In addition, when a unilateral denervation of the SON was assessed, a decrease in the number of follicles was observed in the denervated ovary and a compensation (observed as an increase in the number of follicles) was observed in the innervated ovary (Moran et al 2000). In addition, it has been demonstrated that the sympathetic innervation of follicles influences follicular maturation/growth (Mayerhofer et al 1997, Paredes et al 2011, steroidal secretion (Hernandez et al 1988, Barria et al 1993 and ovulation (Kannisto et al 1985).…”

Section: Sympathetic Innervation and Ovarian Ageingmentioning

confidence: 99%

“…This means that the sympathetic adrenergic vasoconstrictor response in the ovary is well preserved in rats aged 28-31 months old. In addition to regulating ovarian blood flow, extrinsic ovarian innervation directly regulates steroidogenesis (Aguado & Ojeda 1984) and follicular development (Lara et al 1993, Moran et al 2000, Rosa et al 2003, Doganay et al 2010, Zhang et al 2010. Both α and β adrenergic receptors are expressed in the ovarian follicles (Aguado et al 1982, Barria et al 1993, Itoh & Ishizuka 2005, Fernandois et al 2012, and direct effects of NE on follicles could be produced by α1 and β2 adrenergic receptor stimulation (Laszlovszky & Erdo 1983, Itoh & Ishizuka 2005.…”

Section: Sympathetic Innervation and Ovarian Ageingmentioning

confidence: 99%

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation

2017

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Successful reproduction is the result of a myriad interactions in which the ovary and the ovarian follicular reserve play a fundamental role. At present, women who delay maternity until after 30 years of age have a decreased fertility rate due to various causes, including damaged follicles and a reduction in the reserve pool of follicles. Therefore, the period just prior to menopause, also known as the subfertile period, is important. The possibility of modulating the follicular pool and the health of follicles during this period to improve fertility is worth exploring. We have developed an animal model to study the ovarian ageing process during this subfertile period to understand the mechanisms responsible for reproductive senescence. In the rat model, we have shown that the sympathetic nervous system participates in regulating the follicular development during ovarian ageing. This article reviews the existing evidence on the presence and functional role of sympathetic nerve activity in regulating the follicular development during ovarian ageing, with a focus on the subfertile period. Free Spanish abstract: A Spanish translation of this abstract is freely available at http://www.reproduction-online.org/content/153/2/ R59/suppl/DC1. Reproduction (2017) 153 R59-R68

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Effects of unilateral or bilateral superior ovarian nerve section in infantile rats on follicular growth

Cited by 20 publications

References 22 publications

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Surgical denervation of porcine ovaries during the middle luteal phase of the oestrous cycle changes their morphology and steroidogenic activity

Role of the central and peripheral nervous system in the ovarian function

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation

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