Differential neural cell adhesion and neurite outgrowth on carbon nanotube and graphene reinforced polymeric scaffolds

Gupta, Pallavi; Agrawal, Akriti; Kumarasamy, Murali; Varshney, Ritu; Beniwal, Swen; Manhas, S. K.; Roy, Partha; Lahiri, Debrupa

doi:10.1016/j.msec.2018.12.065

Cited by 52 publications

(31 citation statements)

References 74 publications

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“…Figure 2H depicts the stress-strain curve at 80% compressive strain, respectively. The mechanical strength, an essential factor for fabricating scaffolds for bone tissue engineering, demonstrates the load bearing capacity of the materials (Gupta et al, 2019). The compressive strength values at 80% strain for GA, nHAp-GA, GO-GA, and nHAp-GO/GA are 5.98, 6.80, 11.89, and 14.72 MPa, respectively.…”

Section: Physical Characterization Of Nhap-go/ga Nanocomposite Scaffoldmentioning

confidence: 99%

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

et al. 2020

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Graphene oxide (GO) and nanohydroxyapatite (nHAp) proved to be a potential material for bone tissue-regeneration applications. Therefore, GO and nHAp reinforced porous polymeric nanocomposite scaffolds have been gaining significant research thrust. In this study, GO and nHAp based nanocomposite was synthesized and used as a reinforcing agent to develop gelatin-alginate (GA)-based three-dimensional porous polymeric nanocomposite scaffold. The polymeric nanocomposite scaffold (nHAp-GO/GA) was fabricated by using freeze-drying process, which may show a synergistic effect of each of the components for tissue regeneration. The scaffold demonstrates good physico-chemical properties. The porous microstructure of the scaffold is evidenced by Field emission scanning electron microscopy (FESEM). High swelling of the scaffold in presence water, indicates that the scaffold is highly hydrophilic, which implies the suitability of the scaffold for tissue regeneration. Further, the incorporation of nHAp-GO enhances the compressive strength of the scaffold while reduces the rate of biodegradation, which is good for bone tissue engineering. The scaffold is biocompatible. In vitro cell study with MG-63 bone cells demonstrates the synergistic effect of each of the components of the scaffold, on mineral deposition. Therefore, it can be concluded that nHAp-GO/GA polymeric nanocomposite scaffold can be a potential candidate for bone tissue regeneration.

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Section: Physical Characterization Of Nhap-go/ga Nanocomposite Scaffoldmentioning

confidence: 99%

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

et al. 2020

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“…The main application of CNTs for neural engineering, as well as for other types of tissue engineering, is the use of them as a scaffold for the stem cells. Recently, Gupta et al reported on the fabrication hybrid scaffolds made of multi-walled CNTs/chitosan and graphene nanoplatelets/chitosan [147]. The results of the study demonstrated a good electric conductivity, elasticity, and high cyto-compatibility of hybrid scaffolds.…”

Section: Carbon Nanotubes and Stem Cellsmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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“…To overcome these limitations, biocompatible and biodegradable polymers are the most commonly used materials in the field. Usually, polymeric materials are blended with bioceramics, bioglasses or stimuli-responsive biomaterials such as electrical conductive carbon nanomaterials or magnetic nanoparticles, to improve physical and biological properties [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering

et al. 2021

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Scaffolds play a key role in tissue engineering applications. In the case of bone tissue engineering, scaffolds are expected to provide both sufficient mechanical properties to withstand the physiological loads, and appropriate bioactivity to stimulate cell growth. In order to further enhance cell–cell signaling and cell–material interaction, electro-active scaffolds have been developed based on the use of electrically conductive biomaterials or blending electrically conductive fillers to non-conductive biomaterials. Graphene has been widely used as functioning filler for the fabrication of electro-active bone tissue engineering scaffolds, due to its high electrical conductivity and potential to enhance both mechanical and biological properties. Nitrogen-doped graphene, a unique form of graphene-derived nanomaterials, presents significantly higher electrical conductivity than pristine graphene, and better surface hydrophilicity while maintaining a similar mechanical property. This paper investigates the synthesis and use of high-performance nitrogen-doped graphene as a functional filler of poly(ɛ-caprolactone) (PCL) scaffolds enabling to develop the next generation of electro-active scaffolds. Compared to PCL scaffolds and PCL/graphene scaffolds, these novel scaffolds present improved in vitro biological performance.

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Differential neural cell adhesion and neurite outgrowth on carbon nanotube and graphene reinforced polymeric scaffolds

Cited by 52 publications

References 74 publications

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

Fabrication of Graphene Oxide and Nanohydroxyapatite Reinforced Gelatin–Alginate Nanocomposite Scaffold for Bone Tissue Regeneration

The Advances in Biomedical Applications of Carbon Nanotubes

Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering

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