Differential microemulsion polymerization as a new root for entrapment of drugs

Moustafa, A. B.; Sobh, Rokaya Aly; Rabie, Ahmed; Nasr, H. E.; Ayoub, Magdy M. H.

doi:10.1002/app.38059

Cited by 11 publications

(14 citation statements)

References 60 publications

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“…The loading efficiency or EE depends on drug type, monomer composition, and polymer to drug ratio. It can be calculated as follows:49,50 …”

Section: Resultsmentioning

confidence: 99%

“…39 Drug EE Both of the hydrophilic sodium warfarin drug (an anticoagulant drug) as well as the hydrophobic ibuprofen (non-steroidal antiinflammatory drug) and praziquantel drugs (antiparasite drug) were entrapped through differential microemulsion copolymerization of (MMA/HEMA) in the presence of biocompatible emulsifiers (PVP/PEG) producing copolymeric nanospheres with monomer feed composition of MMA/HEMA as 90/10, 70/ 30, and 50/50, with three different drug content in monomer to drug ratios as 20 : 1, 10 : 1, and 6 : 1. 48 The entrapped amount of each drug was quantified by an indirect method as depicted in the experimental part. The loading efficiency or EE depends on drug type, monomer composition, and polymer to drug ratio.…”

Section: Influence Of Hema Content On the Colloidal Propertiesmentioning

confidence: 99%

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Synthesis and in vitro release of guest drugs‐loaded copolymer nanospheres MMA/HEMA via differential microemulsion polymerization

Moustafa

Sobh

Rabie

et al. 2012

J of Applied Polymer Sci

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The synthesis and characterization of different series of methyl methacrylate/hydroxyethyl methacrylate (MMA/HEMA) copolymeric nanoparticles with different monomer feed compositions and utilization of them in entrapment and controlling the release of hydrophilic drug (sodium warfarin) and hydrophobic drugs (ibuprofen and praziquantel) were investigated. The polymeric nanoparticles and their entrapment with drugs were prepared using oil‐in‐water (O/W) differential microemulsion polymerization technique in the presence of polyvinyl pyrrolidone and polyethylene glycol as biocompatible emulsifiers as well as ammonium persulfate as an initiator. The effect of HEMA content in the monomer feed composition on the colloidal properties was studied, and it is found that the particle size Dv, turbidity, and the negative charge increase with increasing of HEMA content but the surface tension decrease. Moreover, the entrapment efficiency (EE) is affected by the content of HEMA in the monomer feed composition, the drug hydrophobicity, and the monomer to drug ratio. It is concluded that, EE into MMA/HEMA in monomer feed composition as 90/10, 70/30, and 50/50 is found to be (95.3–98)%, (84–96.9)%, and (69.5–94.6)% for sodium warfarin (with high hydrophilicity) as well as, ibuprofen and praziquantel (with high hydrophobicity), respectively. The entrapment of drugs in polymeric nanoparticles is confirmed by IR‐spectroscopy and transmission electronic microscopy. In vitro drug release experiments show that controlled release of drugs from copolymeric nanoparticles depend on HEMA content, the monomer to drug ratio, and the physiological pH. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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“…The loading efficiency or EE depends on drug type, monomer composition, and polymer to drug ratio. It can be calculated as follows:49,50 …”

Section: Resultsmentioning

confidence: 99%

Section: Influence Of Hema Content On the Colloidal Propertiesmentioning

confidence: 99%

Synthesis and in vitro release of guest drugs‐loaded copolymer nanospheres MMA/HEMA via differential microemulsion polymerization

Moustafa

Sobh

Rabie

et al. 2012

J of Applied Polymer Sci

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“…The value of ζ for 5-FU-loaded MWCNTs/(MMA/HEMA50/50) nanocomposite is -1.34 mV. This means that the incorporation of functionalized MWCNTs shifts the zeta potential from -0.6 to -1.34 mV, which results from the existence of the carboxylic groups after the acidic functionalization of the MWCNTs [7,8]. The particle size measurements, Table 1, also show the increase of the particle size from 150 nm to 240 nm by the incorporation of CNTs to form 5-FU loaded-MWCNTs/copolymeric(50/50) nanocomposite with 5-FU/MWCNTs ratio of 1:1.…”

Section: Zeta Potential and Particle Sizementioning

confidence: 95%

“…The microemulsion technique can produce polymer latexes with particle sizes lower than 50 nm, low viscosity, and wide temperature range stability [4,5]. In situ microemulsion polymerization is considered to be an effective method in drug entrapment during the formation of polymer nanosphere [6][7][8]. In the drug delivery application, CNTs were used due to their hollow nanostructures and fantastic physicochemical features [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tailoring nano-copolymer/CNTs composite and its application in drug delivery

et al. 2021

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This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these groundbreaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.

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“…The drug EE was defined as the ratio of the weight of the drug loaded into the spinning fiber to the weight of the drug initially used [15].…”

Section: Drug Entrapment Efficiency (Ee%)mentioning

confidence: 99%

Preparation and Characterization of Melt Spun Polypropylene / Montmorillonite Nanocomposite Fibre for Ibuprofen Drug Delivery application

Elsayed¹,

Elsharif

Mohamed³

2018

Egypt. J. Chem.

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P OLYPROPYLENE /Montmorillonite clay nanocomposite was prepared after modification of Montmorillonite (MMT) clay using Dimethyl di (hydrogenated tallow) ammonium chloride modifier. The prepared nanocomposite was characterized using scanning electron microscope (SEM), Fourier-transform infrared (FTIR) and thermal gravimetric analysis (TGA). Fibers of pure polypropylene (PP) and polypropylene/montmorillonite clay nanocomposite (PP/MMT) were produced using melt spinning technique and the prepared fibers were characterized using mechanical properties, water absorption in addition to SEM analysis. The results show that the nanocomposite fibers have higher thermal stability, higher mechanical properties, and lower water absorption than pure polypropylene fibers in addition to high degree in homogeneity between polypropylene and MMT clay in polypropylene/montmorillonite nanocomposite. Ibuprofen drug (IBU) was successfully loaded into polypropylene and polypropylene/montmorillonite clay nanocomposite fiber via solvent immersion method with different drug fiber ratio in presence of glyoxal cross linker. Drug release profile was studied for 120 min and the results showed that about 33% from the initial loaded drug was released from the fiber after one hour of release starting time.

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Differential microemulsion polymerization as a new root for entrapment of drugs

Cited by 11 publications

References 60 publications

Synthesis and in vitro release of guest drugs‐loaded copolymer nanospheres MMA/HEMA via differential microemulsion polymerization

Synthesis and in vitro release of guest drugs‐loaded copolymer nanospheres MMA/HEMA via differential microemulsion polymerization

Tailoring nano-copolymer/CNTs composite and its application in drug delivery

Preparation and Characterization of Melt Spun Polypropylene / Montmorillonite Nanocomposite Fibre for Ibuprofen Drug Delivery application

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