Differential impact of severity of drug use on frontal behavioral symptoms

Verdejo-García, Antonio; Rivas, Cristina; López-Torrecillas, Francisca; Pérez-Garcı́a, Miguel

doi:10.1016/j.addbeh.2005.11.003

Cited by 86 publications

(70 citation statements)

References 31 publications

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“…These support our hypothesis that heroin-dependent and major depression subjects have shared frontal GMV alterations compared to health controls. The present findings also are consistent with other structural and functional neuroimaging studies which found disruptions of the frontal cortex in individuals with repeated drug abuse including heroin-dependence (Upadhyay et al, 2010;Vasic, Walter, Hose & Wolf, 2008;Verdejo-Garcia, Rivas-Perez, Lopez-Torrecillas & Perez-Garcia, 2006). …”

Section: Discussionsupporting

confidence: 92%

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

Mwansisya¹,

Zhang²,

Wang³

et al. 2016

Int J Emerg Ment Health

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Section: Discussionsupporting

confidence: 92%

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

Mwansisya¹,

Zhang²,

Wang³

et al. 2016

Int J Emerg Ment Health

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“…The standard version of the Self Rating Form of the FrSBe aims to measure behavioral change by obtaining pre-and post-lesion ratings. For the purposes of this study and in keeping with previous research (Lyvers et al, in press;Spinella, 2003;Verdejo-García, Rivas-Péreza, López-Torrecillasa, & Pérez-García, 2006) (Stout, Ready, Grace, Malloy, & Paulsen, 2003) with the three factor solution accounting for 40.7% of the common variance. Evidence also supports reliability (Velligan, 2002) with internal consistency ranging from .88 to .91 and three month test-retest reliability of .78.…”

Section: Methodsmentioning

confidence: 79%

Negative mood regulation expectancies, frontal lobe related behaviors and alcohol use

Lyvers

Thorberg

Ellul

et al. 2010

Personality and Individual Differences

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“…Additionally, these immoral choices are perceived without having any scruples (Carmona-Perera et al, 2012). Behavioral symptoms such as apathy, executive dysfunction and loss of inhibition were correlated with the severity of polysubstance addiction, but not uniformly across the variety of substances (Verdejo-García et al, 2006). Although use severity,for cocaine and ecstasy, was related to higher disinhibited behavior, acute doses of alcohol, cannabis and heroin were linked to higher scores in the apathy subscale of the Frontal System Behavior Scale (FrSBe) (Verdejo-García et al, 2006).…”

Section: Abnormal Resting-state Topological Properties In Heroin-depementioning

confidence: 99%

“…Although use severity,for cocaine and ecstasy, was related to higher disinhibited behavior, acute doses of alcohol, cannabis and heroin were linked to higher scores in the apathy subscale of the Frontal System Behavior Scale (FrSBe) (Verdejo-García et al, 2006). Moreover, intensive use of alcohol and cannabis was involved in executive deficits (Verdejo-García et al, 2006).…”

Section: Abnormal Resting-state Topological Properties In Heroin-depementioning

confidence: 99%

Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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Differential impact of severity of drug use on frontal behavioral symptoms

Cited by 86 publications

References 31 publications

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

Major Depressive Disorder and Heroin-dependent Patients Share Decreased Frontal Gray Matter Volumes: A Voxel-Based Morphometry Study

Negative mood regulation expectancies, frontal lobe related behaviors and alcohol use

Resting-state Abnormalities in Heroin-dependent Individuals

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