“…For E1, in a second step, the dichlorinated TP undergoes an oxidative chlorination at position 10, leading to a trichlorinated product 2,4,10-trichloro-1,4-estradiene-3,17-dione, and a further substitution at the same position by a hydroxy group [45]. For EE2, eight hydroxylated and halogenated forms were detected, but some uncertainties remain concerning the exact positions of the hydroxy and halogen groups [30]. Finally, in the case of E2, besides three chlorinated products (2,4-dichloro-E2, monochloro-E1 and 2,4-dichloro-E1), four TPs formed by ring cleavage through 9-10 and 16-17 bonds were identified [59].…”