A non-target approach to identify disinfection byproducts of structurally similar sulfonamide antibiotics

Wang, Mian; Helbling, Damian E.

doi:10.1016/j.watres.2016.06.042

Cited by 45 publications

(22 citation statements)

References 46 publications

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“…digestion, composting, etc.,) [5,20] or in DWTPs during oxidation steps [12,21,22]. These TPs can retain a biological activity [21,23,24] which may pose risks towards aquatic ecosystems or human health. Ciprofloxacin is the main metabolite of the veterinary antibiotic enrofloxacin, and it is also a pharmaceutical used in human medicine.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Oxidation processes can lead to the formation of oxidation by-products that may be more toxic than the parent compound. Currently, the formation pathway, the chemical structure and the potential impacts towards human health of those transformation products are largely unknown [21].…”

Section: Oxidation Processesmentioning

confidence: 99%

“…Free chlorine (i.e. hypochlorite anion and hypochlorous acid) is a non-selective oxidant widely used in DWTP at the disinfection step [21,23]. In full-scale DWTPs, different behaviours of VPRs were observed when reacting with free chlorine.…”

Section: Chlorinationmentioning

confidence: 99%

See 2 more Smart Citations

Veterinary pharmaceutical residues from natural water to tap water: Sales, occurrence and fate

Charuaud

Jardé

Jaffrézic

et al. 2019

Journal of Hazardous Materials

232

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Veterinary pharmaceuticals (VPs) increasingly used in animal husbandry have led to their presence in aquatic environments -surface water (SW) or groundwater (GW) - and even in tap water. This review focuses on studies from 2007 to 2017. Sixty-eight different veterinary pharmaceutical residues (VPRs) have been quantified worldwide in natural waters at concentrations ranging from nanograms per liter (ng L) to several micrograms per liter (μg L). An extensive up-to-date on sales and tonnages of VPs worldwide has been performed. Tetracyclines (TCs) antibiotics are the most sold veterinary pharmaceuticals worldwide. An overview of VPRs degradation pathways in natural waters is provided. VPRs can be degraded or transformed by biodegradation, hydrolysis or photolysis. Photo-degradation appears to be the major degradation pathway in SW. This review then reports occurrences of VPRs found in tap water, and presents data on VPRs removal in drinking water treatment plants (DWTPs) at each step of the process. VPRs have been quantified in tap water at ng L concentration levels in four studies of the eleven studies dealing with VPRs occurrence in tap water. Overall removals of VPRs in DWTPs generally exceed 90% and advanced treatment processes (oxidation processes, adsorption on activated carbon, membrane filtration) greatly contribute to these removals. However, studies performed on full-scale DWTPs are scarce. A large majority of fate studies in DWTPs have been conducted under laboratory at environmentally irrelevant conditions (high concentration of VPRs (mg L), use of deionized water instead of natural water, high concentration of oxidant, high contact time etc.). Also, studies on VPRs occurrence and fate in tap water focus on antibiotics. There is a scientific gap on the occurrence and fate of antiparatic drugs in tap waters.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Oxidation Processesmentioning

confidence: 99%

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Veterinary pharmaceutical residues from natural water to tap water: Sales, occurrence and fate

Charuaud

Jardé

Jaffrézic

et al. 2019

Journal of Hazardous Materials

232

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“…To illustrate the potential for our geospatially resolved dataset to evaluate quantitative predictions, we developed a case study utilizing an empirical equation for trihalomethane (THM) formation to predict potential transformations in FracFocus reported wells. Here, we note explicitly that inuences from biodegradation 25,51,52 (or biotransformation 43,53,54 ), physical mixing (e.g., relative contribution of injected uid versus formation water), and chemical transport 53,55-58 on quantitative outputs are not considered, but could be added to such models in the future when sufficient data and theory are available. Starting with Chowdhury et al's 59 thorough review of THM generation models, we selected one model by Hong et al 47 for its basis in natural water and construction around water quality parameters relevant to subsurface hydraulic fracturing uids; i.e., bromide concentration, pH, DOC, and temperature.…”

Section: Case Study 2: Empirical Thm Formation Modelingmentioning

confidence: 99%

A geospatially resolved database of hydraulic fracturing wells for chemical transformation assessment

Sumner

Plata

2020

Environ. Sci.: Processes Impacts

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“…This approach can be employed to study chemical fate processes in the environment. It has been used to identify contaminant transformation products, 13,14,[23][24][25] but there are few reports of this strategy being employed to investigate other processes. 18,[26][27][28][29] In the present study, we further explored the process-oriented applications of non-target analysis by using this technique to evaluate the overall RE of organic contaminants in WWTPs.…”

Section: Introductionmentioning

confidence: 99%

High-throughput evaluation of organic contaminant removal efficiency in a wastewater treatment plant using direct injection UHPLC-Orbitrap-MS/MS

Undeman

Papa

et al. 2018

Environ. Sci.: Processes Impacts

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The removal efficiency (RE) of organic contaminants in wastewater treatment plants (WWTPs) is a major determinant of the environmental impact of these contaminants. However, RE data are available for only a few chemicals due to the time and cost required for conventional target analysis. In the present study, we applied non-target screening analysis to evaluate the RE of polar contaminants, by analyzing influent and effluent samples from a Swedish WWTP with direct injection UHPLC-Orbitrap-MS/MS. Matrix effects were evaluated by spiking the samples with isotope-labeled standards of 40 polar contaminants. For 85% of the compounds, the matrix effects in the influent and effluent were not significantly different. Approximately 10 000 compounds were detected in the wastewater, of which 319 were identified by using the online database mzCloud. Level 1 identification confidence was achieved for 31 compounds for which we had reference standards, and level 2 was achieved for the remainder. RE was calculated from the ratio of the peak areas in the influent and the effluent from the non-target analysis. Good agreement was found with RE determined from the target analysis of the target compounds. The method generated reliable estimates of RE for large numbers of contaminants with comparatively low effort and is foreseen to be particularly useful in applications where information on a large number of chemicals is needed.

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A non-target approach to identify disinfection byproducts of structurally similar sulfonamide antibiotics

Cited by 45 publications

References 46 publications

Veterinary pharmaceutical residues from natural water to tap water: Sales, occurrence and fate

Veterinary pharmaceutical residues from natural water to tap water: Sales, occurrence and fate

A geospatially resolved database of hydraulic fracturing wells for chemical transformation assessment

High-throughput evaluation of organic contaminant removal efficiency in a wastewater treatment plant using direct injection UHPLC-Orbitrap-MS/MS

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