2012
DOI: 10.3892/or.2012.2105
|View full text |Cite
|
Sign up to set email alerts
|

Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies worldwide. To reduce the high morbidity and mortality of the disease, sensitive and specific biomarkers for early detection are urgently needed. Tumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. In this study, differentially expressed miRNAs in tumor tissues and adjacent non-tumor tissues were detected by mi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

4
62
1
1

Year Published

2013
2013
2023
2023

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 88 publications
(69 citation statements)
references
References 50 publications
4
62
1
1
Order By: Relevance
“…Another downregulated miRNA, miR-25, may function as a tumor suppressor that inhibits cell proliferation and migration by targeting Smad 7 in colon cancer (44) and EZH2 in anaplastic thyroid carcinoma (45). Finally, studies have suggested a tumor suppressor role for miR-139-5p, which is downregulated in various types of cancer, including endometrial serous adenocarcinoma (46), breast carcinoma (47), glioblastoma (48), bladder cancer (49), basal cell carcinoma (50) and esophageal squamous cell carcinoma (51).…”
Section: Discussionmentioning
confidence: 99%
“…Another downregulated miRNA, miR-25, may function as a tumor suppressor that inhibits cell proliferation and migration by targeting Smad 7 in colon cancer (44) and EZH2 in anaplastic thyroid carcinoma (45). Finally, studies have suggested a tumor suppressor role for miR-139-5p, which is downregulated in various types of cancer, including endometrial serous adenocarcinoma (46), breast carcinoma (47), glioblastoma (48), bladder cancer (49), basal cell carcinoma (50) and esophageal squamous cell carcinoma (51).…”
Section: Discussionmentioning
confidence: 99%
“…Abnormal expression of miRNAs in a variety of tumor cells is involved in cell differentiation, proliferation, and apoptosis and is closely associated with tumor development, diagnosis, treatment, and prognosis; thus, these miRNAs have clinical significance (Gramantieri et al, 2008;Selaru et al, 2009). Recent studies have found that miR-21 can enhance the radiosensitivity of esophageal cancer down TE-1 cells, and a number of studies have shown that miRNA expression is significantly associated with esophageal cancer prognosis (Hummel et al, 2011;Yang et al, 2013). In this study, we examined miR-21 expression in esophageal tissue and cultured cells and investigated the effects of miR-21 on apoptosis and invasion of esophageal cancer cells using cell transfection techniques.…”
Section: Introductionmentioning
confidence: 99%
“…Bu süreçte artan mir-8485 miktarının sinir sistemi farklılaşmasını baskıladığı düşünülebilir. mir-601'in hücre bölünmesini bir çok kanser türünde miktarının arttığı ve kanser dokularında biriktiği gösterilmiştir [38,39] . mir-548i görevleri tam anlaşılmayan miRNA'lardan olmakla beraber embriyonik kök hücrelerde tespit edilmiştir [40] .…”
Section: Discussionunclassified